Term
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Definition
-rapid response of blood and local tissues to remove injurious agent (microbes, foreign substances and abnormal cells)
-limits tissue damage
-involves exudate of fluid/plasma components |
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Term
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Definition
protective response to injury and infction
-can cause bystander damage to normal cell tissue |
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Term
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Definition
vascular stage
cellular stage |
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Term
| Cause smooth muscle relaxation and vessel dilation to inc blood flow in vascular stage (2) |
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Definition
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Term
| histamine leukotrienes n brdykinins cause endothelial |
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Definition
| cell retraction to inc gaps of venules to allow the outflow of fluid and serumproteins to action site |
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Term
| stimulation of exposed nerve endings by ________ and ___________ cause pain |
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Definition
| histamine and bradykinins |
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Term
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Definition
-release cytokines IL-6,IL-1b,TNFa
-inc liver prod. of fibrinigen,C-reactive protein[CRP], and serum amyloid protein(SAA) |
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Term
CRP binds to...
SAAs displace .....
Fibrinogen converted to fibrin by.... |
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Definition
-C-polypeptide of pneumococci to tag for phagocytosis
-Apolipoprotein A in HDL to facilitate transfer of HDL from liver to macrophages for energy
-Thrombus for clot formation |
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Term
| Fever generation[protective response] |
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Definition
cytokines(IL-6,IL-1,TNFa) from activated immune cells induce PGE2 release
-PGE2 acts on PGE receptor 3 in hypothalamus to inc heat generation>>>>>inc muscle tone & shivering and dec heat loss through vasoconstriction |
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Term
chronic inflmtn response....
key cell mediators...
repaired by.... |
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Definition
-response....slow[weeks to years]
-key cell mediators...monocyte/macrophage,lymphocyte,plasma cells,fibroblasts
-repaired by....fibrosis & angiogenesis, may cause permanant func loss |
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