Term
| Inhibit bacterial protein synthesis by binding to 30S ribosomal subunit. Blocks tRNA binding to complex. Bacteriostatic. |
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| Irreversible inhibition of bacterial protein synthesis by binding to 30S ribosomal subunit blocking biding of mRNA to ribosome, causing misreading of mRNA. Bacteriocidal. |
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| Inhibits bacterial protein syntehsis through binding to 50S RNA subunits. Inhibited due to inhibition of aminoacyl translocation reaction. Bacteriostatic, at high concentrations Bacteriocidal. Binds to one domain of 23S rRNA of 50S ribosomal subunit. |
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Protein synthesis inhibited through interaction with 50S ribosomal RNA subunit and inhibiting aminoacyl translocation.
Binds to two separate domains (II and IV) of 23S rRNA of 50S ribosomal subunit. |
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| inhibits cross linkage of peptide side chains of bacterial cell wall. Transpeptidation step. Primarily Bactericidial. |
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| Interacts with b-lactamases destroying them. |
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| peptide antibiotic, inhibits bacterial cell wall synthesis |
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| bactericidal glycoprotein. Inhibits bacterial cell wall synthesis by inhibiting synthesis of bacterial cell wall PHOSPHOLIPIDS. Also inhibits peptidoglycan cross linking or polymerization. |
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| Unique mechanism of action. LIPOPEPTIDES interact with bacterial membranes inducing rapid polarization of membrane potential. Leads to cell death through indirection inhibition of DNA, protein, and RNA synthesis |
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| Inhibits synthesis of bacterial cell walls. Effective vs. gram positive and negative. Resistance due to decreased permeability. Synergistic w/ aminoglycosides, B lactams, or fluoroquinolones. |
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| Inhibition of bacterial cell wall syntehsis. Active vs gram positive and negative. Orally effective second line agent. |
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Term
| Behaves similar to cationic detergents. Binds to and disrupts bacterial cell membranes |
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| blocks binding of charged tRNA to acceptor site on 50S ribosome-mRNA complex. Therefore peptide @ donor site can't be transferred. |
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| binds to 50S subunit of bacterial ribosome, thus inhibiting the translocation steps of protein synthesis |
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| inhibits bacterial protein synthesis via a unique mechanism of action; therefore, it lacks cross resistance w/ other classes of antimicrobial agents |
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Similar MOA to aminoglycosides; inhibits bacterial protein synthesis by interferring with bacterial ribosome function.
Blocks 30S ribosomal subunit, blocking binding of mRNA to ribosome, causing misreading of mRNA |
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| antimetabolite; inhibits synthesis of bacterial folic acid |
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antimetabolite; inhibits synthesis of bacterial folinic acid (tetrahydrofolate)
analog of dihydrofolic acid ; potent and selective inhibitor of dihydrofolate reductase (DHFR) which reduces dihydrofolate to THF. Bacterial DHFR has greater affinity for this than mammilian form of the enzyme accounting for its selective toxicity. |
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| antimetabolite; inhibits synthesis of folinic acid similar to trimethoprim |
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| structural analogs of PABA; they compete with PABA for dihydropteroate synthetase inhibiting incorporation of PABA into bacterial folic acid |
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Definition
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| synergistic actions. first reduces production of folic acid from PABA, second inhibits conversion of dihydrofolate to tetrahydrofolate |
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Definition
| SMX-TMP (Trimethoprim + sulfmethoxazole) Co-trimoxazole |
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Term
| interfere with bacterial DNA replication, transcription, and repair through inhibition of DNA GYRASE (topoisomerase II) during bacterial proliferation. |
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| these also inhibit topoisomerase IV, essential for chromosomal DNA partitioning during bacterial cell division. |
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Definition
| Fluroquinolones (third and fourth generation) |
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Term
| inhibits bacterial protein synthesis by disrupting process necessary for protein synthesis. Interacts w/ 23S ribosomal RNA on 50S ribosome, thereby inhibiting formation of INITIATION COMPLEX and translation in G+ bacteria. |
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Definition
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Term
| synergistically inhibit bacterial protein synthesis through interaction w/ bacterial ribosome. |
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Definition
| Quinupristin-Dalfopristin (Synercid) |
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Term
| ___ inhibits formation of initiation complexes, ___ inhibits aminoacyl translocation reactions |
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Definition
| Dalfopristin, Quinupristin |
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