Term
An intrinsic mechanism for defense against microbial infections.
Occurs without induction
Also called Native or Natural Immunity |
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Definition
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| 4 things about Innate Immunity |
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Definition
First line of defense
Always present to protect us
Deals with a broad range or targets
Fast, efficient, competent |
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Term
| Innate immunity dealing with complement, cytokine, plasma protein |
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Definition
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Term
| Type of innate immunity dealing with PMC, Macrophages, NK, eospinophil |
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| Limited diversity and no clonal expansion |
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Definition
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Definition
| PMN, Monocyte, Macrophate, Dendritic cells |
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Definition
| Nk, NK-T, game-epsilon T, B-1, Marginal Zone B |
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| Cells that are in peritoneal and mucosal cells. IGM antibody |
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Border lines in lymphoid tissue between T and B cells. IGM
Polysacchrides |
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| A process in which cells take up maromolecules from the surrounding medium |
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| Several innate receptors on macrophage bind to microbes, sends a signal to the nucelues, stimulates the formation of a pocket in which BOTH receptor and microbe sit in |
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Term
| A receptor and microbe bound |
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Definition
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| Phagosome fused with lysosome |
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| Produce enzymes and several toxic substances producd that kill microbes |
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| what kind of bacteria walls can be broken down by enzymes in the phagolysosomes |
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| The reverse of endocytosis, components are microbes releasted to extra-cellular fluid |
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Definition
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Term
| several types of specific receptors for different components of microbes |
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Definition
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| Different kind of receptors |
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Definition
| TLR, located in different cellular compartments, cytoplasmic sensor molecules |
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Term
| Capable of singal transduction. Can transmit a singal when its bound, results in cellular responses that are central to innate immunity. Cellular respones include activation of transcription factors which will bind to genes, impact gene transcription. |
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Definition
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Term
Most abundant WBC until adaptive immune reponse starts to work.
Produced in bone marrow upon stimulation by Granulocyte Stimulating Factor
Short life Span
Dominant cell in pus |
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Definition
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| A cytokine that recruits PMN to the site of infection |
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Definition
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A longer life-span than PMN
First cell type responding to microbes
Phagocytosis
Antigen presentation
Major producer of cytokines
Major coordinator between innate and adaptive immune response |
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Definition
Monocyte-when in blood
Macrophages-when in tissue |
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Term
| In the local tissue. Takes up a microbe by phagocytosis and this results in the production of cytokines (IL-1 or TNF) |
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Definition
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| Mediate weak thethering to endothelial walls and rolling of blood neutrophils |
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Definition
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| Mediate firm adhesion of leukocyte to endothelium |
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Definition
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| Process where the leukocyte wiggles between the cells |
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Definition
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| Purpose of rolling and diapedesis |
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Definition
| To slow leukocytes by letting them roll along the endothelial layer contacting selectin ligands, until integrin firmly binds the leukocyte to the endothelial wall. Then migrate through the endothelial cell layer |
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