Shared Flashcard Set

Details

Miscellaneous Antibiotics
IDIT: WALTERS
23
Pharmacology
Professional
02/08/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Chloramphenicol Mechanism
Definition
  • IV for resistant and serious anaerobic/aerobic
  • inhibits binding of aminoacyl tRNA acceptor site.
Term
Chloramphenicol Side Effects
Definition
  • Fatal blood dyscrasias
  • Inhibits mammalian mitchondrial peptidyltransderase. Esp erythropoietic cells
  • Deficient in G6PD will lead to hemolytic anemia
  • Inhibits cytochrome P450
  • Grey Baby Syndrome
Term
Quinupristin/Dalforpristin Mechanism
Definition
  • Singly are Static, juntos r Cidal
  • Syngeristically releases peptidyl tRNA from donor of peptidyltransferase (Q) (Quit!)
  • inhibits binding of aminoacyl tRNA to acceptor sie of peptidyl tRNA to donor site of eptidyltransferase (D) (DONT!)
Term
Quini/Dalforpristins Side Effects
Definition
  1. Inhibit CYP3A
  2. Only IV
  3. Superinfection with colitis and C. diff
  4. Arthralgias/myalgias
  5. Venous irritation, hyperbilirubinemia
Term
Linezolid Uses
Definition
  • Enterococcus faeium
  • MSSA, MRSA
  • Vancomycin resistant drugs
  • Static or cidal depende en organism
  • Oral or IV
Term
Linezolid Mechanism
Definition
Inhibits formation of initiation complex
Term
Linezolid Side Effects
Definition
  • 5-HT syndrome
  • Dyscrasias
  • Colitis
  • Chronic use causes optic neuropathy (rev) peripheral neurophthy (irre) and lactic acidosis
Term

Clindamycin Mechanism

 

Definition
  • inhibits translocation A-P site, has some immunomodulatory activity, can be used with PCN for group A strep
Term
Clindamycin Risk
Definition

Pseudomembranous colitis.

CANNOT penetrate CNS, even if meninges inflamed

Term
Polymyxin B Mechanism
Definition

cidal cationic DETERGENT that makes pores in lipid bilayer

Term
Polymyxin B Side Effects
Definition

Very nephro and neurotoxic

Causes neuromuscular block like aminoglycosides

Term
Colistimthate Characteristics
Definition
  • IV IM for G- rods
  • Also a cationic detergent
  • Cidal
  • Very nephrotxin and neurotoxic
Term
Spectinomycin Characteristics
Definition
  • Related to aminoglycosides but static not cidal
  • IM, single 2gm dose
  • Used for gonorrhea, PCN resistant or PCN allergic people
Term
Rifaximin Mechanism and Uses
Definition
  • Binds DNA and dependent RNA polymerase
  • Used in traveler's diarrhea and decrease risk hepatic encephalopathy
  • Not systemmic
Term
Rifamixin Side Effects
Definition
  • "Colon" things
  • flatulence, abdominal pain, urgency to defecate,
Term
Two Drugs for Impetigo
Definition
  • Mupirocin and Retamulin
Term
Mupirocin Mechanism
Definition
  • inhibits bacterial isoleucyl tRNA synthetase
Term
Retapamulin Mechanism
Definition
  • blocks acceptor and donor site of peptidyl transferase
Term
Daptomycin Mechanism
Definition
  • For MRSA and G+
  • forms pores in cytoplasmic membrane, loss of K+ depolarization and inhibition of DNA RNA and protein synthesis
Term
Daptomycin Side Effects
Definition
  • Increase creatine kinase
  • Do not use with pneumonia, is deactivated by lung surfactant
Term
Quinidine Shit
Definition

IV for life threatening P. falciparum

Can cause arrhythmias

Monitor ECG!

Term
Rifampicin Mechanism and Use
Definition

* Use vs staph and MRSA, penetrate biofilm well

* Inhibit DNA dependent RNA polymerase

Kills intracellular and extracellular organisms

Term
Rifampin Side Effects
Definition

* More than 2 weeks will cause flu like symptoms

* Red orange color to urine, feces, saliva, sweat, tears

* Jaundice with fatalities rare

Hepatitis rare if normal liver

* Monitor liver because it excretion almost completely in Bile

*

Supporting users have an ad free experience!