• IV for resistant and serious anaerobic/aerobic
• inhibits binding of aminoacyl tRNA acceptor site.

• Fatal blood dyscrasias
• Inhibits mammalian mitchondrial peptidyltransderase. Esp erythropoietic cells
• Deficient in G6PD will lead to hemolytic anemia
• Inhibits cytochrome P450
• Grey Baby Syndrome

• Singly are Static, juntos r Cidal
• Syngeristically releases peptidyl tRNA from donor of peptidyltransferase (Q) (Quit!)
• inhibits binding of aminoacyl tRNA to acceptor sie of peptidyl tRNA to donor site of eptidyltransferase (D) (DONT!)

1. Inhibit CYP3A
2. Only IV
3. Superinfection with colitis and C. diff
4. Arthralgias/myalgias
5. Venous irritation, hyperbilirubinemia

• Enterococcus faeium
• MSSA, MRSA
• Vancomycin resistant drugs
• Static or cidal depende en organism
• Oral or IV

• 5-HT syndrome
• Dyscrasias
• Colitis
• Chronic use causes optic neuropathy (rev) peripheral neurophthy (irre) and lactic acidosis

Clindamycin Mechanism

• inhibits translocation A-P site, has some immunomodulatory activity, can be used with PCN for group A strep

Pseudomembranous colitis.

CANNOT penetrate CNS, even if meninges inflamed

cidal cationic DETERGENT that makes pores in lipid bilayer

Very nephro and neurotoxic

Causes neuromuscular block like aminoglycosides

• IV IM for G- rods
• Also a cationic detergent
• Cidal
• Very nephrotxin and neurotoxic

• Related to aminoglycosides but static not cidal
• IM, single 2gm dose
• Used for gonorrhea, PCN resistant or PCN allergic people

• Binds DNA and dependent RNA polymerase
• Used in traveler's diarrhea and decrease risk hepatic encephalopathy
• Not systemmic

• "Colon" things
• flatulence, abdominal pain, urgency to defecate,

• Mupirocin and Retamulin

• inhibits bacterial isoleucyl tRNA synthetase

• blocks acceptor and donor site of peptidyl transferase

• For MRSA and G+
• forms pores in cytoplasmic membrane, loss of K+ depolarization and inhibition of DNA RNA and protein synthesis

• Increase creatine kinase
• Do not use with pneumonia, is deactivated by lung surfactant

IV for life threatening P. falciparum

Can cause arrhythmias

Monitor ECG!

* Use vs staph and MRSA, penetrate biofilm well

* Inhibit DNA dependent RNA polymerase

Kills intracellular and extracellular organisms

* More than 2 weeks will cause flu like symptoms

* Red orange color to urine, feces, saliva, sweat, tears

* Jaundice with fatalities rare

Hepatitis rare if normal liver

* Monitor liver because it excretion almost completely in Bile

*