Term
| What are proteosome inhibitors? |
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Definition
The proteosome degrades IkB allowing NFkB to make cytokines. Inhibition = no NFkB
- Bortexomib - IV/SQ. Cardiotoxic
- Carfilzomib - IV, cardiotoxic |
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Term
| What are immunoregulatory agents? |
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Definition
Incr innate immunity: G1 arrest, inhibit adhesion, decr angiogenesis, increase NK cells
- Thalidomide - PO, a severe teratogen
- Lenalidomide - PO, Teratogen, less severely toxic
- Pomalidomide - PO, teratogen |
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Term
| How does L-asparaginase work? |
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Definition
Some tumors require exogenous asparagine - deprives them of this.
- L-asparaginase - can be pegylated. Allergic rxns - a protein drug. Inhibits protein synthesis: decr insulin/hyperglycemia, decr clotting factors, hyptriglycerides |
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Term
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Definition
Causes single/double DNA breaks - max lifetime dose of 400 units. IM/SQ
Tissue distribution into SKIN and LUNG - pulmonary fibrosis and cutaneous rxns |
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Term
| How does Omacetaxine work? |
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Definition
- Binds to ribosomal A site - inhibition of protein synthesis. Nothing to do with taxanes
- SQ, glucose intolerance |
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