Term
|
Definition
(140-159/90-99)
Tx: thazide diuretics
considerations: ACEI, ARB, BB, CCB |
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Term
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Definition
(>160/>100)
2 DRUG COMBINATION:
THIAZIDE+ ACEI
THIAZIDE+ ARB+CCB+BB |
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Term
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Definition
(120-139/80-89)
Tx: lifestyle changes |
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Term
| HYPERTENSION + ANGINA (DRUGS) |
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Definition
| BB (tenormin), CCB (diltiazam) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
FUROSEMIDE
BUMETANIDE
TORSEMIDE
ETHACRYMIC ACID
MOA: Na/K/2Cl- inhibitor (metabolic acidosis)
Diuretic + gentamycin= increased ototoxicity |
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Term
|
Definition
MANNITOL
UREA
MOA: inc. osmolarity PCT
Indications: inc. intracranial/intraocular pressure; acute renal failure |
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Term
| CARBONIC ANNHYDRASE INHIBITORS |
|
Definition
ACETAZ(OLAMIDE)
DOR(ZOLAMIDE)
tx for glaucoma and overdose acidic drugs (alkalinize urine)
MOA: inc. excretion Na, K, HCO3
S/E: hyperchloremia, metabolic acidosis, hypokalemia |
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Term
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Definition
SPIRONOLACTONE (aldosterone antagonist) (dec libido)
TRIAMTERENE
AMILORIDE (block Na reabsorption TQ: tx nephrogenic DI by Li)
collecting duct
ACEI +sprironolactone=inc surv HF pt |
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Term
|
Definition
HYDROCHLOROTHIAZIDE
INDAPAMIDE
MOA: inhibit Na/Cl transport
HYPERCALCEMIA (TQ) and hyperuricemia--> toe pain in morning
DCT |
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Term
|
Definition
ENALA(PRIL)
LISINO(PRIL)
S/E: HYPERKALEMIA, ACUTE RENAL FAILURE
diabetes + HT
DRY COUGH**
VASODILATION VIA BRADYKININ & EDRF |
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Term
| ANGIOTENSIN II RECEPTOR BLOCKERS |
|
Definition
LO(SARTAN)
VAL(SARTAN)
CANDE(SARTAN)
INDE(SARTAN)
REDUCE VASOCONSTRICTION
NO DRY COUGH |
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Term
|
Definition
ATEN(OLOL)
LABET(OLOL)
CARVED(OLOL)
mask signs of hypoglycemia
abrupt w/d causes HYPOTENSION |
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Term
|
Definition
AMLO(DIPINE)
NIFRE(DIPINE)
NIMO(DIPINE)-> TX FOR subarachnoid hemorrhage
ISRA(DIPINE)
BW:DIHYDROPYRIDINES( VASCULAR TISSUE); REFLEX TACHYCARDIA (flushing, ankle edema)
block L type Ca channels |
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Term
|
Definition
DILTIAZEM
VERAPAMIL
ACTS ON HEART (dec contractility, possible AV block) |
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Term
|
Definition
CLONIDINE (rebound HT)
ALPHA METHYL DROPS (+ coombs test-hemolytic anemia) |
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Term
| ADRENERGIC NEURONAL BLOCKING DRUGS |
|
Definition
GUANETHIDINE (binds storage ves. and prev. NE release)
RESERPINE (TQ): binds storage vesicles and destroys them; psychotic effects and suicide) |
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Term
|
Definition
TERA(ZOCIN)
DOXA(ZOCIN)
PRA(ZOCIN)
for HT, BPH
TQ: incontinence in women when coughing, sneezing or lifting a weight. |
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Term
|
Definition
direct acting vasodilator
relaxes art. SM
BW: SLE Like syndrome, hemolytic anemia |
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Term
|
Definition
DAV
TQ: accumulation cyanide + thiocyanate |
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Term
|
Definition
DAV
activate K+ channels--> SM relaxation
S/E: hypertrichosis |
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Term
|
Definition
activates K+ channels hyperglycemia, hypertrichosis
Tx for insulinoma |
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Term
|
Definition
block K+ channel
TQ: treat insulinoma |
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Term
|
Definition
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Term
|
Definition
| diuretics, ACE inhibitors |
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Term
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Definition
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Term
| increased peripheral resistance |
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Definition
alpha 2 agonist
alpha 1 blocker
CCB
direct acting vasodilator |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
REPOLARIZATION
dec K current |
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Term
|
Definition
resting potential
Na/K atp pump |
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Term
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Definition
class 1A
activated Na channel
dec Vmax and prolonged action potential duration (APD)
BW: inc APD and ERP in atria,
inc QT interval and torsades de pointe |
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Term
|
Definition
Class 1A na channel blockers
active metabolite NAPA
S/E: AGRANULOCYTOSIS; SLE like syndromes |
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Term
|
Definition
the most anticholinergic Na channel blocker
dry mouth |
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Term
|
Definition
acts at Na inactivated channel
lidocaine, tocamide, mexiletine
no effect Vmax, dec APD |
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Term
|
Definition
tx for Vtac after MI, or digitalis toxicity
give before you shock the heart |
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Term
|
Definition
both Na channels
dec of Vmax, but no effect on APD
flecainide and miricizine
increase in sudden death and cardiac arrest post MI |
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Term
|
Definition
propranolol, acebutolol, esmolol (t 1/2=8 min)
dec SA and AV nodal conduction
prophylaxis post MI and tx for SVT |
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Term
| class 3: K+ channel blockers |
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Definition
inc APD & ERP
prolong repol. and lenghten phase 2
Bretylium: tx of life threatening v arrhythmia not controlled by IA or IB
causes orthostatic hypotension and reflex tachycardia |
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Term
|
Definition
class 3 blocker
mimics class 1,2,3,4
binds Na, K, Ca channels
S/E surf skin, hypothyroidism, torsades de points |
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Term
|
Definition
class 3 blocker
beta blocker & K channel blocker
tx of life threatening V arrhythmia
S/E: careful with asthmatic |
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Term
|
Definition
Ca channel blocker
dec SA & AV nodal conduction (dec slope phase 4)
Verapamil, Diltiazem
tx of PSVT due to AV nodal activity |
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Term
|
Definition
vasodilation--> reflex tachycardia
tx for PSVT
antagonist: theophylline
corrects hypokalemia and hypomagnesia |
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