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| Study of how drugs affect mood, perception, thinking, or behaviour |
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| Drugs that affect mood, perception, thinking, or behaviour by acting in the nervous system |
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| The study of how drugs affect behaviour. Sometimes behavioural pharmacologists emphasize principles used in the field of behaviour analysis |
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| The study of how drugs affect the nervous system and how these nervous system changes alter behaviour |
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| Drugs used for treating disorders |
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| An administered substance that alters physiological functioning |
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| Using a drug to address a specific purpose |
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| Drugs used to treat a physical or mental disorder |
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| Using a drug entirely to experience the drug's effects |
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| A trademarked name a company provides for a drug |
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| A nonproprietary name that indicates the classification for a drug and distinguishes it from others in the same class |
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| Ratio of the amount of drug per an organism's body weight |
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Definition
- Effective Dose 50 Value
- Represents the dose at which 50 percent of an effect was observed |
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| Amount of drug used to produce a certain level of effect |
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| Ratio of a drug's toxic dose-effect curve value relative to therapeutic dose-effect curve value |
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- A therapeutic index calculated by dividing a TD 1 (Toxic Dose in 1%), value by an ED99 (Effective dose in 99%) value
- Very conservative. Ensures safety. |
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Definition
| The physiological actions of drugs |
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Definition
| A drug's passage through the body |
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| The study of how genetic differences influence a drug's pharmacokinetic and pharmacodynamic effects |
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| Pharmacological effects that can be directly observed by others |
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| Pharmacological effects that cannot be directly observed by others |
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Term
| Profile of Mood States Questionnaire (POMS) |
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Definition
-Asks participants to rate the degree of agreement with a word or statement that describes how they might feel from "a little" to "extremely"
- Used for measuring subjective effects of drugs |
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Definition
| Study in which an investigator does not alter the independent variable. Does not demonstrate any causal relationships |
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| Researchers alter a study's independent variable and observe changes in a dependent variable. Can identify causal relationships between independent and dependent variables. |
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| Substance identical in appearance to a drug but physiologically inert |
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| Number of treatments and doses provided to patients described in a clinical study. ie. One treatment and placebo = Two arms. Two different doses and one placebo = 3 arms |
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| Detailed summaries of a clinical study's design and results |
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| When researchers do not inform study participants which treatment or placebo they received |
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| When neither participants nor investigators know the treatment assignments during a study |
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Definition
Assignment of study treatments without using blinded procedures.
Used in cases where disguising study medications may have serious ethical or medical consequences (ex. chemo drugs) |
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| Control of variables with potential to influence a dependent variable |
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| Ability to extend findings beyond study conditions |
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| Test appears to measure what a researcher considers it to measure |
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| How well a study's findings relate to the underlying theory of a study's obejectives |
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| Ability of a model to predict treatment effects |
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Definition
| A substance harmful to a fetus |
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Definition
Replacement, Reduction and Refinement
Ethical questions regarding animal testing
*Institutional Animal Care and Use Committee |
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Definition
| Assessment that weighs the value of potential research discoveries against the potential pain and distress experience by research subjects |
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Term
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Definition
| Consent gained after a participant thoroughly understands a study's procedures, possible gains, and potential risks |
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| Why are animals used for psychopharmacological research? |
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Definition
- Because they have a high predictive value
- Because there are no other viable alternatives |
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Term
| 6 Stages of Therapeutic Drug Development |
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Definition
1. Identify Disorder to Treat
2. Drug synthesis
3. Biological experimentation
4. Focused screening methods
5. Safety pharmacology
6. Clinical Trials |
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Term
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Definition
| A government approved therapeutic drug experiment in humans' drug development; a multistep process of developing an effective, safe, and profitable therapeutic drug |
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