Term
| what are the 3 types o cell injury? |
|
Definition
1.Reversible (cell recovery)
2. apoptosis
3. necrosis |
|
|
Term
| what enzymes become elevated in blood with heart damage? |
|
Definition
|
|
Term
| what enzymes become elevated in blood with liver damage? |
|
Definition
1.ALT
2.AST
3.Alkaline phosphatase
4.LDH |
|
|
Term
| what enzymes become elevated in blood with pancreatic damage? |
|
Definition
|
|
Term
| what enzymes become elevated in blood with muscle damage? |
|
Definition
|
|
Term
| what are 4 ultrastructural changes in reversible cell injury? |
|
Definition
1.pm alterations...blebbing
2.mito swell & get amorphous
3.diation of ER and ribosomal detachment
4.nuclear alterations |
|
|
Term
| what is the most common change in cell injury? |
|
Definition
|
|
Term
| what are the 5 distinct patterns of change in reversible cell injury? |
|
Definition
*1. cellular swelling
*2. hydropic changes/vacuolar degen
*3. fatty changes
4. Hyaline
5. Glycogen |
|
|
Term
| what is an early manifestation of all types of cell injury? |
|
Definition
| cellular swelling-reversible but considered to be sublethal |
|
|
Term
| this is usually seen in poisonings like CCl4, polychorinated biphenyls,fever, chicken pox,herpes,hypokalemia |
|
Definition
| Hydropic change/vacuolar degeneration. more severe than cellular swelling-cisternae of ER dilate, rupture and form discrete water pockets |
|
|
Term
| any abnormal accumulation of triglycerides within parenchymal cells |
|
Definition
| steatosis...most common cause alcoholism. lack of choline & methionine render liver unable to mobilize fat. most freq in liver,CNS, spleen, kidneys, skeletal muscle and occasionally heart |
|
|
Term
| name 4 metabolic disorders of fat metabolism |
|
Definition
1. Lysosomal storage diseases (gauchers,tay,neimann)
2.Steatorrhea
3. Lipofuscin
4. Hand Schuller Christian Disease |
|
|
Term
|
Definition
|
|
Term
| one of the patterns of reversible cell injury, condition in which there is accumulation of proteins within cells |
|
Definition
| hyaline degeneration-"glassy" 1. metabolites from protein digestion get released from lysosomes damaging cellular organelles 2. excess intracellular protein can push against organelles disrupting function and communication |
|
|
Term
| what are 5 types of hyaline degen? |
|
Definition
1.Zenker's (waxy) degen-skel m.
2.Malloy bodies-liver, alcoholism
3.Counciman bodies-acidophilic or apoptopic
4.Crooke's-pit gland & cushing's-+ cortisol
5.Russel bodies-b lymphs, mott cell |
|
|
Term
| what is the most common lysosomal storage disease that stems from steatosis? |
|
Definition
| Gaucher's-glucocerebricides build up in RE cells,pinguecula in eyes, "wrinkled tissue paper in cells" |
|
|
Term
| lysosomal disease where gangliosides build up in brain |
|
Definition
| tay sachs->mental retardation, death by 2-3yo |
|
|
Term
| lysosomal storage disease with sphingomyelin and cholesterol involvement |
|
Definition
| Neimann-Picks-spleen,liver, marrow, lymph nodes, lungs,CNS |
|
|
Term
| abnormal proteinaceous substance that is deposited in many cells and organs of the body in a variety of clinical disorders |
|
Definition
| AMYLOIDOSIS. rare disease and cause is unknown-Vit C def,cronic infections,RA,hodgkins, horses hyperimmunized for diptheria antitoxin production |
|
|
Term
| ability of WBCs to move toward an injured area/ response to stimulus of inflammation/and or injury |
|
Definition
|
|
Term
| accumulation of intermdiate filaments in liver cells in alcoholic liver disease |
|
Definition
|
|
Term
| exogenous material brought into cell via endocytosis or phagocytosis |
|
Definition
| heterophagy-ex.neutrophils |
|
|
Term
| cell removes its own damaged organelles |
|
Definition
|
|
Term
| lysosomes with undigested particles which may or may not be extruded eventually |
|
Definition
|
|
Term
| benign tumors having abundant & enlarged forms (found in kidney, thyroid, parathyroid, & salivary glands) |
|
Definition
|
|
Term
| aka for heat shock proteins |
|
Definition
| chaperonins-normally produced in cells playing roles in: intracellular housekeeping, protein folding, disaggregation, transport |
|
|
Term
| class of functionally related proteins whose expression is increased when cells are exposed to elevated temperatures or other stress |
|
Definition
|
|
Term
| because heat shock proteins function as chaperones for other proteins, they play an important role in folding. What diseases can ensue from abnormal HSPs? |
|
Definition
-Alzheimer's
-Creutzfeldt-Jacob disease
-Mad Cow-refolding problem of prions |
|
|
Term
| what is the first observable evidence of intracellular damage |
|
Definition
| Mito and plasma membrane-within 15min, mito form fine granules and pm thickens-blebs |
|
|
Term
| endocytotic invaginations on membrane |
|
Definition
|
|
Term
| what are the 3 intracellular changes in injury and death of the cytoplasm? (becomes homogenous and eosinophilic) |
|
Definition
1. mito and pm change
2.increase water and sodium accumulation
3. disorganization - lysosomes disappear, fat accumulates at fat droplets |
|
|
Term
| what are 3 changes due to breakdown of DNA? |
|
Definition
1. pyknosis-stains dif-blue
2. karyorrhexis-nuclear dust
3. karyolysis |
|
|
Term
| what are the 7 types of necrosis? |
|
Definition
1.coagulative
2.liquefactive
3.caseous
4.fat
5.gangrenous
6.gummatous
7.fibrinoid |
|
|
Term
| which type of necrosis is never found in the brain? |
|
Definition
|
|
Term
| which tissues are most freq involved in coagulative necrosis? |
|
Definition
1.heart (infarcts)
2.kidney
spleen,lungs,adrenal glands |
|
|
Term
| what is the cause of coagulative necrosis? |
|
Definition
| ischemic cell death followed by protein degredation, something to do w/increased intracellular calcium->opaque,dry, yellowish mass |
|
|
Term
| characteristic of focal bacterial or fungal infections and CNS |
|
Definition
| liquefactive necrosis "colliquative"->WBC abcess,pus from hydrolases released from PMNs liquify bacteria |
|
|
Term
| examples of liquifactive necrosis |
|
Definition
| boils,carbuncles,furuncles->brain infarcts |
|
|
Term
| what can cause fat necrosis? |
|
Definition
| trauma, abnormal release of pancreas enzymes-lipase->chalky white flecks. saponification. fatty acids combine with Ca,Na,Mg and create soaps |
|
|
Term
| what causes caseous necrosis? |
|
Definition
| granulomatous inflammation-interactions of T lymphs,macrophages and cytokines. TB,Pott's disease,Tularemia,L. venereum-disease carried by chlamydia |
|
|
Term
| what is the appearance of caseous necrosis? |
|
Definition
| white, cheesy,putty,bubos |
|
|
Term
| necrosis with bacterial activity |
|
Definition
|
|
Term
| this type of necrosis results from interference in blood supply (ischemia) |
|
Definition
| dry gangrene-no bacteria involved-skin appears dry,brown or black. ergotism-mycotoxin C. purpurea on grain->acral |
|
|
Term
| bed sores aka decubitus ulcers are a form of___ caused by ___ |
|
Definition
|
|
Term
| tertiary syphillis causes which type of necrosis? |
|
Definition
|
|
Term
| what is the first most noticeable sign of somatic death? |
|
Definition
| complete cessation of respiration and circulation. skin->pale,yellow. CO poisoning->sometimes lips and cheeks stay life like |
|
|
Term
| what is algor mortis and when does it occur? |
|
Definition
| cooling of body. starts gradually then speeds up. 1st 3 hrs after death decrease of 3.5 and then 1.5 per hour |
|
|
Term
| stiffening of body is called |
|
Definition
|
|
Term
| what is the cause of body stiffening after death? |
|
Definition
| carbs breakdown and ATP in muscle gets depleted; interferes with actin and myosin leading t stiffness as acidic compounds accumulate in muscle. As cellular proteins degen and actin and myosin fibers decompose, it goes away=putrefaction (24-36hrs after death) |
|
|
Term
|
Definition
| livor mortis. lividity=skin discoloration=bluish color from pooling of blood in capillaries |
|
|
Term
| what is the 1st distinctive sign of putrefaction? |
|
Definition
| green discoloration of abdomen caused by post mortem disinegration of blood |
|
|
Term
| what is the order of disinegration of blood in putrefaction? |
|
Definition
| stomach lining,gall bladder,small intestines,brain, kidney tubules |
|
|
Term
| mass formed from blood constituents within a vessel or the heart during life |
|
Definition
| thrombosis. physiological protective mechanism but can become pathological |
|
|
Term
| which protein is a good test for inflammation? |
|
Definition
| C Reactive Protein. Its physiological role is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via the C1Q complex. |
|
|
Term
| what is a Virchow's Triad? |
|
Definition
--all lead to thrombosis
1. Endothelial injury
2. blood flow changes
3. Hypercoagulability |
|
|
Term
| what do endothelial cells make normally in order to prevent thrombosis? |
|
Definition
1. nitric oxide
2.prostacyclin
3.antithrombin |
|
|
Term
| thrombosis is started by a release of ___ and ___activators |
|
Definition
| vasoconstrictors,platelet. endothelin & von willebrand factor->thromboxin A->stimulates more platelets |
|
|
Term
| deformation of vessel walls, swellings or compressions can cause turbulence called |
|
Definition
|
|
Term
| what are the 5 major charecteristics of thrombi? |
|
Definition
1.Adhere to endothelium
2.bend in direction of blood flow
3.maj form in veins (towards heart)
4.maj break apart and form embolism
5. lines of Zahn |
|
|
Term
| what are 4 areas of freq occurence of thrombi? |
|
Definition
1.Veins of lower extremities
2. varicose veins
3. post-operative patients (esp pelvis)
4. lungs (peripheral area) |
|
|
Term
| the ability of a solid substance to be reduced to smaller pieces with little effort. |
|
Definition
| Friability. The opposite of friable is indurated. |
|
|
Term
| an antemortem thrombus exhibits lines of zahn. what are they? |
|
Definition
| lines represent that this formed from flowing blood. Pale area=fibrin and platelets. dark area=RBCs |
|
|
Term
| T or F. a postmortem clot adheres to a vessel wall. |
|
Definition
| False. Blood moves to an area, clots and conforms to a vessel wall not adheres |
|
|
Term
| what do postmortem clots look like? |
|
Definition
| Gelatinous, rubbery, moist. Part where RBCs settle looks like dark currant jelly and top fluid part looks like yellow chicken fat |
|
|
Term
| what is the diff btn arterial and venous thrombi? |
|
Definition
| Art=white from platelets, lines of zahn, brain and coronary aa. common. vein=red from RBCs, not well dev lines of zahn maybe bc blood is not moving as fast? |
|
|
Term
| arterial thrombi arising in heart chambers and/or aorta |
|
Definition
|
|
Term
| thrombi occuring as a result of damage from microbial or fungal infections--vegetations |
|
Definition
| valvular thrombi-endocarditis (strep) aortic and mitral valves most common |
|
|
Term
| 5 steps in fate of thrombi |
|
Definition
1.shrinkage and contraction
2. recanalization
3. lysis
4. resolution
5. organized and incorporated into vessel wall |
|
|
Term
| what is a sign of a thromus where one has pain in calf upon dorsiflexion of foot? |
|
Definition
|
|
Term
| what is the most important of embolic diseases? caused by? |
|
Definition
| Pulmonary emboli blocking flow of pulmonary artery. Deep femoral veins with phlebthrombosis is most likely source |
|
|
Term
| what is the most important cause of arterial thrombosis? |
|
Definition
| Atherosclerosis. Most common of the 3 types of arteriosclerosis |
|
|
Term
| arterial inflammation accounting for some cases of thrombosis |
|
Definition
| Arteritis (increased C Reactive protein) |
|
|
Term
| what can protect epithelial cells from thrombosis formation? |
|
Definition
| Heparin (body's natural blood thinner) PG12 (type of prostaglandin derived from arachadonic acid released during inflammation) |
|
|
Term
| what can protect the liver from thromobosis formation? |
|
Definition
|
|
Term
| a detacted intravascular solid, liquid or gas carried by blood to a site distant from point of origin |
|
Definition
| Embolus. Thrombus is stationary, embolus is a thrombus which travels |
|
|
Term
| what are the 11 types of emboli? |
|
Definition
1.pulmonary
2.solid or systemic
3.saddle
4.paradoxical
5.infected
6.amniotic
7.gas
8.fat
9.tumor
10.bone marrow (flail chest)
11.talc (IV drug users) |
|
|
Term
| what is the most common type of emboli? |
|
Definition
| pulmonary. 2nd is fat emboli |
|
|
Term
| 95% of this type of emboli originate from deep leg veins above knee and usually from post-op patients,CHF |
|
Definition
| pulmonary emboli-considered to be the most common preventable death in a patient |
|
|
Term
| this type of emboli usually arises from heart |
|
Definition
| solid or systemic. LA-mitral stenosis; LV-MI; mid cereb a=cerebral infarction; mesenteric=intest infarction; renal aa.=wedge shaped paleness in renal cortex |
|
|
Term
| this is the most serious form of thrombi |
|
Definition
| Saddle embolus. lodges at bifurcation of vessel, main pulmonary artery |
|
|
Term
|
Definition
| paradoxical embolus. congenital septal defect... |
|
|
Term
| embolus from ruptured appendix...septic clot |
|
Definition
| infected emboli-from pyogenic org |
|
|
Term
|
Definition
| Caisson's disease-the bends, Nitrogen slow to resolubilize |
|
|
Term
| least likely site for secondary amyloidosis? |
|
Definition
| Lungs. Most likely: spleen, kidneys, liver, adrenal glands |
|
|
Term
| giant, atypical histocytes found in Hodgkin's lymphoma |
|
Definition
|
|
Term
| in acute inflammation, what is the most mobile cell present? |
|
Definition
|
|
Term
| type of necrosis that produces an infarct in the kidney |
|
Definition
|
|
Term
| liquefaction necrosis occuring in the CNS is followed by |
|
Definition
|
|
Term
| an elevated scar resulting from extensive fibrous tissue formation |
|
Definition
| keloid. more freq among brunettes and darker skinned people |
|
|
Term
| which organ is most susceptible to enzymatic necrosis? |
|
Definition
|
|
Term
| what produces coagulation necrosis? |
|
Definition
|
|
Term
| liquefaction necrosis is commonly seen where? |
|
Definition
| brain infarcts and abcesses (bacterial associated) |
|
|
Term
| coagulation necrosis is seen? |
|
Definition
| Myocardial infarcts and in most tissue except brain |
|
|
Term
| which cells do not regenerate after injury? |
|
Definition
| sriated muscle and neurons |
|
|
Term
| type of necrosis found in an infarct |
|
Definition
|
|
Term
| the most constant initial finding as a tissue alteration in an area of inflammation |
|
Definition
|
|
Term
| fat necrosis occurs most freq in |
|
Definition
|
|
Term
| parenchymatous repair means healing by |
|
Definition
|
|
Term
| why is a venous thrombus not as serious as an arterial? |
|
Definition
| extensive collateral circulation |
|
|
Term
| What is the inflammatory response regardless of the agent? |
|
Definition
1.Blood vessels dilate
2.Fluid in cells goes to site-WBCs
3.Proteolytic degradation of extracellular debris
4.connective tissue repair of fibroblasts |
|
|
Term
| what are the cardinal signs of inflammation? |
|
Definition
RTDCF
1.rubor
2.dolor
3.tumor
4.calor
5.functio lasea |
|
|
Term
| what are the 2 basic forms of inflammation? |
|
Definition
1.ACUTE-neutrophils,fluid & plasma protein exudates
2.CHRONIC-lymphs & macrophages, tissue destruction & repair |
|
|
Term
| At what stage of inflammation do you ice? |
|
Definition
Acute-ice (48-72hrs)
Chronic-heat
Subacute-alternate |
|
|
Term
| what is the role of vessels in hemodynamics of inflammation? |
|
Definition
-initial vasoconstriction
-vasodilation (arteries->veins->cap |
|
|
Term
| what happens to the body from vasodilation? |
|
Definition
| hyperemia (redness & warmth) |
|
|
Term
| what happens to blood flow in hemodynamics of inflammation? |
|
Definition
-initial acceleration to area then slow down->statis
-Plasma leaks out from vessels leaving more concentrated blood in vessels->thick sludge |
|
|
Term
| What happens to RBCs in inflammation? |
|
Definition
| become sticky and adhere to one another in masses, helping in sluddging or packing of blood mass |
|
|
Term
| what happens to the endothelium in inflammation? |
|
Definition
| -lining goes from neg charge to pos charge which allows for attraction of WBCs. |
|
|
Term
|
Definition
| The movement or passage of blood cells, especially white blood cells, through intact capillary walls into surrounding body tissue. Also called migration. Vascular lining perforates during inflammation (intracellular spaces and gaps |
|
|
Term
| what is the hallmark of acute inflammation? |
|
Definition
| Edema-(swelling) intravascular pressure and interstitial luid osmotic pressure increases-> edema due to more water and ions into extravascular tissue |
|
|
Term
| what produces transudate? |
|
Definition
| blood flow->intravascular hydrostatic pressure->fluid filtration from capillaries to interstitial tissue=fluid mostly water w/few cells and proteins |
|
|
Term
|
Definition
| Inflam. Increased vascular permeability lets protein rich fluid and cells into interstial tissue |
|
|
Term
| what are the 3 steps involved with WBCs and inflammation? |
|
Definition
RAT-
1. rolling-Selectins
2. adhesion-IFA Proteins & Integrin
3. transmigration |
|
|
Term
| Rolling of WBCs produces _ and _ where they stack up next to each other and form a wall |
|
Definition
| margination and pavementing |
|
|
Term
| WBCs role in inflammation is phagocytosis and then release of lysosome enzymes. What are the 3 stages of phagocytosis? |
|
Definition
1. Opsonins
2.Engulfment-triggered by opsonins. Pseudopod formation->phagocytic vacuoles in cell
3.killing and degredation |
|
|
Term
| what does the killing and degredation in WBCs after phagocytosis? |
|
Definition
1. superoxidation
2. Halogenation
3. Lipid peroxidation |
|
|
Term
| what happens in stage 1 of phagocytosis in WBCs? |
|
Definition
Opsonins help in recognition and attachment of WBCs and coat bacteria and bind to receptor sites on cells.
EX: IgG & C3 (complement) |
|
|
Term
| what are the 3 types of granulocytes? name an aka |
|
Definition
1. neutrophils
2.Eosinophils
3.Basophils
aka-myelocytes
Agranulocytes are lymphocytes,monocytes |
|
|
Term
| What WBC is the first to arrive in acute inflammation? |
|
Definition
| Neutrophils. Phagocytic. Most readily affected by chemotaxis. Also 1st in bacterial infections (antibacterial) |
|
|
Term
|
Definition
Process by which somatic cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (for example, glucose) by swimming towards the highest concentration of food molecules, or to flee from poisons (for example, phenol). In multicellular organisms, chemotaxis is critical to early development (e.g. movement of sperm towards the egg during fertilization) and subsequent phases of development (e.g. migration of neurons or lymphocytes) as well as in normal function. In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis.
Positive chemotaxis occurs if the movement is towards a higher concentration of the chemical in question. Conversely, negative chemotaxis occurs if the movement is in the opposite direction. Chemotaxis is the process by which white blood cells are drawn to the site of inflammation. White blood cells recognize foreign particles through mannose and scavenger receptors. Opsonins are particles that bind to foreign material and signal leukocytes to remove it. |
|
|
Term
| when are eosinophils the key player? |
|
Definition
| chronic allergies. phagocytic to Ag/Ab complexes |
|
|
Term
| what cells are the key players in acute allergies? |
|
Definition
| Basophils (in blood)->Mast cells in tissues which contain heparin (prevents clotting in inflammation) and histamine (Type 1 Hypersensitivity) |
|
|
Term
|
Definition
| fluid exudates; high protein content including fibrinogen moving out of dilated vessels (2nd fluid) 1st fluid-transudate; low protein ultrafiltrate of blood plasma |
|
|
Term
| what are 4 things that act as chemotactic agents? |
|
Definition
1.soluble bacterial products
2.components of complement system (C5)
3.products of arachidonic acid metabolism (leukotrienes)
4.cytokines |
|
|
Term
|
Definition
| small cell-signaling protein molecules secreted by the glial cells of the nervous system and by numerous cells of the immune system. category of signaling molecules used extensively in intercellular communication. Can be classified as proteins, peptides, or glycoproteins; the term "cytokine" encompasses a large and diverse family of regulators produced throughout the body by cells of diverse embryological origin.Term "cytokine" has been used to refer to the immunomodulating agents, such as interleukins and interferons. Biochemists disagree as to which molecules should be termed cytokines and which hormones. |
|
|
Term
| what is fibrin and how is it formed? |
|
Definition
| fibrillar protein polymerised to form a "mesh" ->hemostatic plug or clot (in conjunction with platelets) over a wound site. Involved in signal transduction, blood coagulation, platelet activation, and protein polymerization. Formed by the conversion of fibrinogen with help of thrombin |
|
|
Term
| what are 4 direct actions to exogenous agents |
|
Definition
1. agglutination-particulate antigens bind into clumps
2. Precipitation-soluble antigens->precipitate
3. neutralization-ant inactivated by antibody
4. Lysis-antibody attacks cell wall->lysis, usually complement assists |
|
|
Term
|
Definition
| Plasma proteins playing a role in inflamation and immunity. System of over 30 distinct beta globulins made by liver and found in blood plasma. When IgG or IgM combine with antigen, complement will assist it and the result will be lysis of the cell |
|
|
Term
| What is the rhogam shot for? |
|
Definition
| To prevent rheusus disease or hemolytic disease of the newborn. The medicine is a solution of IgG anti-D (anti-RhD) antibodies that bind to, and lead to the destruction of, fetal Rh D positive red blood cells that have passed from the fetal circulation to the maternal circulation. |
|
|
Term
| what does a complement do? |
|
Definition
| 1st there is a cascade effect after activation by a specific antigen-antibody complex. Then they attack-punch holes in invader's membrane allowing for increased permeability of WBC chemotaxis-C3 esp involved in this process |
|
|
Term
| what are the 4 types of hypersensitivity reactions |
|
Definition
1-anaphylatic/Immediate
2-Cytotoxic-hemolytic anemia/blood trans
3-Immune mediated/Arthus
4-Delayed/cell mediated |
|
|
Term
| Which type of Hypersensitivity is local: hayfever, urticaria; systemic: peanut butter, penicillin, insect bites? |
|
Definition
| I-vasoactive substance affects vascular permeability and smooth muscle |
|
|
Term
| Which hypersensitivity associated with myasthenia gravis, thrombocytopenia, grave's disease? |
|
Definition
| II-humoral antibodies injure cells predisposing them to phagocytosis or lysis |
|
|
Term
| Which hypersensitivity associated with rhematic fever, RA, SLE, acute glomerulonephritis, serum sicknes, pheumonitis? |
|
Definition
| III-symptoms-painful joints, rash, swollen lymph nodes. Humoral antibodies bind antigens and activate complement |
|
|
Term
| Which hypersensitivity associated with contact dermatitis, fungal diseases, leprosy |
|
Definition
| IV-TB-delayed reaction/cell mediated T4 cells 24-72 hrs |
|
|
Term
| After cell membrane phospholipids activate arachidonic acid, what happens? |
|
Definition
1-5-HPETE (chemotaxis)->leukotrines->vasoconstriction, bronchospasm, increased permeability
2-Prostaglandin H2->Prostacyclin and Thromboxane A2 |
|
|
Term
| What does prostacyclin do? |
|
Definition
| causes vasodilation, inhibits platelet aggregation |
|
|
Term
| What does thromboxane A2 do? |
|
Definition
| op of prostacyclin, vasoconstriction,promotes platelet aggregation |
|
|
Term
| T or F Most chemical substances capable of mediating the inflammatory response are Endogenous |
|
Definition
| T. Produced by the body. Most mediators affect vascular permeability |
|
|
Term
| A macrophage releases which interleukin to the T4 Helper cell for activation? |
|
Definition
| lL-1 and then T4 releases 4,5 to help B cells produce plasma cells |
|
|
Term
| This is the hallmark of repair within 3-5days |
|
Definition
| Granulation Tissue. skin under scab when falls off. Pink, soft, new tissue. made of: fibroblasts,endothelial cells, macrophages |
|
|
Term
| This is the hallmark of repair within 3-5days |
|
Definition
| Granulation Tissue. skin under scab when falls off. Pink, soft, new tissue. made of: fibroblasts,endothelial cells, macrophages |
|
|
