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micromeritics
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13
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Undergraduate 3
02/01/2012

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Term
micromeritics
Definition
-science of small particles, such as powders and granules
-studies size, shape, SA, density/porosity, flow/compact/compress
Term
how does solid differ from liquid
Definition
-solids: compacted to density >1, drug is more stable
-liquids: no def. shape, typically homogenous, easier to handle on large manufacturing scale
Term
how does one solid differ from another
Definition
shape, density, size, SA
Term
typical particle size range for pharmaceutical powders
Definition
1 um - 1 mm
Term
PS impact on dosage forms
Definition
dissolution, suspendability, uniformity, penetrability, non-grittiness
Term
very coarse
Definition
>1000
Term
coarse
Definition
355-1000
Term
moderately fine
Definition
180-355
Term
fine
Definition
125-180
Term
very fine
Definition
90-125
Term
comminution
Definition
mechanical process of reducing the PS and aggregates. sieving, trituration, levigation, pulverization by intervention
Term
once a solid is in solution...
Definition
it erases solid history
Term
why do you want a crystalline structure over amorphous and a base over a salt?
Definition
crystalline is less hygroscopic than amorphous and bases are less hygroscopic than acids
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