Term
| Protein Synthesis inhibitors |
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Definition
30:
Aminoglycosides
Tetracycline
50:
Chloramphenicol
Clindamycin
Erythrocyclin (macrolide)
Linezolid
"Buy AT 30, CELL at 50" |
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Term
Binds 23S RNA and interacts with bacterial initiation complex
Used for MRSA and VRE |
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Definition
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Term
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Definition
Gentamycin
Neomycin
Amikacin
Tobramycin
Streptomycin
MOA:bactericidal and inhibits formation of initation complex
Ineffective against anaerobes because it needs Oxygen "amean-O-glycosides" |
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Term
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Definition
Toxicity:
Nephrotoxicity - worse when combined with Cephalosporins
Ototoxicity - worse with Loop diuretics |
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Term
| Binds to 30S and attaches to aminoacyl-tRNA |
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Definition
Tetracyclines:
tetracycline
doxycycline
demeclocycline
minocycline
Vibrio cholera, acne, chlamydia, ureaplasma, urealyticum, mycoplasma pneumoniae, tularemia, H. Pylori, borrelia burgdorferi |
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Term
| What should you never take with tetracyclines? What are the potential side effects? |
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Definition
Milk, antacids, divalent cations (divalent cations inhibits absorption)
Causes tooth discoloration |
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Term
| Drugs that inhibit protein synthesis by blocking translocation; bind to the 23S rRNA of the 50S ribosome |
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Definition
Macrolides:
Erythromycin
Azithromycin
Clarithromycin
Uses (PUS): Pneumonia, atypical pneumonia, URIs, STDs
Toxicity: Prolonged QT interval |
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Term
| Inhibits 50S peptidyltransferase activity. Bacteriostatic |
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Definition
Chloramphenicol
Use: Meningitis (H flu, N meningitidis, s. pneumo)
Toxicity: anemia, aplastic anemia, gray baby syndrome (because they lack UDP glucuronyl transferase) |
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Term
| Blocks peptide bond formation in 50S. Causes pseudomembranous colitis |
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Definition
Clindamycin
Treatment: for anaerobic infections
Lung abcesses, aspiration pneumonias, skin infections (bacterioids fragilis, clostridium perfringens)
Toxicity: Pseudomembranous colitis |
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Term
| Forms toxic metabolites in bacterial cell that damage DNA. Used for protozoa and and anaerobes |
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Definition
Metronidazole
Has disulfiram like effects
GET GAP on the metro
(giardia, entamoeba, Trichomonas, gardernella, anaerobes, h. pylori) |
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