Term
| What is the mode of action of Interferons |
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Definition
| Binds to receptors of infected cells and induces synthesis of proteins that aid in cellular immunity |
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Term
| Inferferson induces oligoisoadenylate synthese that increases ____ activity degrading viral ____ |
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Definition
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Term
When would you use inferons? HINT 5 |
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Definition
1. Genital warts 2. Chronic hep B & C 3. AIDS related Karposi's sarcoma 4. Malignant melanoma 5. Laryngeal papillomatosis |
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Term
| Amantadine & rimantadine interfer w/ fusion of lysosome to membrane by increasing it's pH, this inhibits _______ preventing transfer of _____ _____ |
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Definition
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Term
| When would you give Amantadien & Rimantadine |
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Definition
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Term
| Amantadine & Rimantadine cause _____ & _____ in the elderly |
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Definition
| Hallucinations and Seizures |
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Term
| Zanamivir and Oseltamir are _________ inhibitors that act to reduce viral ________ from cells |
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Definition
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Term
| What would you to prevent influenzae A & B |
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Definition
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Term
| An adverse effect of Oseltamir is |
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Definition
|
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Term
| this drug is phosphorylate to triphosphates that inhibits DNA synthesis being incorporated into viral DNA |
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Definition
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Term
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Definition
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Term
| Photosensitivity is a side of effect of this herpes medication |
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Definition
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Term
| Acyclovir is phosphorylated by viral ______ ______ and inhibits DNA polymerase & _________ into DNA |
|
Definition
thymidine kinase incorporated |
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|
Term
| Acyclovir is used in ___ & _____ |
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Definition
|
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Term
| Valacyclovir is hyrolyzed to ______ in the liver & intestinal wall |
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Definition
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|
Term
| Acyclovir is used as a topical agent for ______ & oral for |
|
Definition
|
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Term
|
Definition
| inhibits DNA polymerase & incorporates in DNA |
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Term
| What are some adverse effects of ganciclovir |
|
Definition
1. Bone marrow suppression 2. thrombocytopenia |
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Term
| Foscarnet is a non-nucleoside inhibit or |
|
Definition
|
|
Term
| When would you use Foscarnett? |
|
Definition
1. Acyclovir resistance HSV and VZV 2. CMV & HSV in AIDS |
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Term
| Give the adverse effects of Foscarnett |
|
Definition
1. Hypocalcemia 2. Neurologic, cardio & renal toxicity |
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Term
| Ribavirin is converted to _________ which inhibits ______ _______ blocking GMP formation & ______ ____ synthesis |
|
Definition
Monophosphates Inosine dehydrogenase Nucleic acid |
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Term
| Foscarnett in aerosol form is used to treat |
|
Definition
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|
Term
| You combine Foscarnett w/ interferon alpha to treat |
|
Definition
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|
Term
| You give IV foscarnett for |
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Definition
|
|
Term
| When should you start HIV theapy |
|
Definition
1. CD < 350 2. Viral load > 100,000 3. Patient symptomatic |
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Term
|
Definition
1. Zidovudine (AZT) 2. Lamivudine (3TC) 3. Emtricitabine (FTC) 4. Abacavir (ABC) 5. Tenofovir (TDF) |
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Term
| What's the mechanism of action of the NRTI drugs |
|
Definition
1. Competetive inhibitor of reverse transcriptase by blocking the incorporation of dNTP 2. dNTP cannot be incorporated into growing viral DNA chain |
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Term
| zidovudine, Lamivudien, Emtricitabine and Abacavir has to be _______ to active _______ |
|
Definition
1. Phosphorylated 2. Triphosphate |
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Term
| What's the mechanism of action of the NRTI drugs |
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Definition
|
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Term
| What are the Adverse effects NRTI |
|
Definition
1. Potent cytochrome p450 2. Elevates triglycerides, cholesterol & glucose |
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Term
| Abacavir produces __________ reaction in 2-4% of patients |
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Definition
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Term
| What's the major adverse reaction of Tenofovir |
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Definition
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Term
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Definition
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Term
| NNRTI changes the conformation of |
|
Definition
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|
Term
| You would not give Efavirnez to ___ |
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Definition
|
|
Term
| Which NNRTI can give you a rash? |
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Definition
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|
Term
| Name the 5 Protease inhibitors |
|
Definition
1. Fosamprenavir 2. Atazanavir 3. Ritonavir 4. Lopinavir/Ritonavir 5. Tipranavir |
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|
Term
| Ritonavir is a potent inhibitor of |
|
Definition
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|
Term
| What are some adverse effects of the HIV protease inhibitors |
|
Definition
1. Mitochondrial toxicity 2. Peripheral neuropathy when taken w/ ddl, ddC & D4t |
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|
Term
| Atazanavir gives you jaundince by? |
|
Definition
| Inhibiting conjugated bilirubin |
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|
Term
| This protease inhibit adverse effects include intercranial bleeding |
|
Definition
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