Term
| Name the 4 properites of Enteroviruses |
|
Definition
1. Non-enveloped 2. (+) ssRNA 3. Resistant to inactivation to detergens 4. Stable at acidic pH or Room temperature |
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|
Term
| Where do the enterovirus replicate? |
|
Definition
| Tonsils of the throat & peyer patches |
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|
Term
| What day to enteroviruses spread to the lymph nodes |
|
Definition
|
|
Term
| When do the first symptoms of enteroviruses appear |
|
Definition
|
|
Term
| How are the enteroviruses transmitted |
|
Definition
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Term
| Name the 3 types of polio in order |
|
Definition
1. Abortive Poliomyelities 2. Nonparalytic Polio 3. Paralytic Polio |
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|
Term
| What's the most common manifestation of polio |
|
Definition
|
|
Term
What are the manifestations of Abortive polio HINT: 4 |
|
Definition
1. Fever 2. Malaise 3. Nausea 4. Sore throat |
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|
Term
| What are the symptoms of Nonparalytic polio |
|
Definition
"Aseptic meningitis" Stiffness & pain in the back & neck |
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|
Term
In regards to polio what phase include the symptoms: 1. Flaccid paralysis 2. Paralysis of all 4 limbs, CN & Muscles of respiration |
|
Definition
|
|
Term
| What are the findings in the CSF of Polio |
|
Definition
1. Increase in leukocytes 2. Increase in proteins 3. Sugar levels remain normal |
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|
Term
| What's the treatment for Polio |
|
Definition
| There is no treatment, it's supportive |
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|
Term
| There are 2 vaccines for Polio what are they |
|
Definition
| Liver attenuated & killed inactivated |
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Term
| Poliovirus is also known as _______ |
|
Definition
| Picornaviridae Enterovirus |
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|
Term
|
Definition
1. Polio 2. Coxsackieviruses 3. Norwalk virus 4. Echovirus 1-31 & 68-72 5. Rotavirus (only one w/ dsRNA) |
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|
Term
| Coxsackievirus B is one of the most common cause of _________ ________ ______ |
|
Definition
| Viral heart disease "Myocardiopathy" |
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|
Term
| Coxsackievirus A is associated w/ ______ & ______ |
|
Definition
1. Herpangina 2. Hand, foot & mouth disease |
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|
Term
|
Definition
| Red oropharynx vesicles, fever, sore throat |
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|
Term
| Coxsackievirus A or B can cause |
|
Definition
1. Aspetic meningitis 2. URT infection |
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|
Term
|
Definition
Enteric Cytopathogenic Human Orphan |
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Term
Echovirus can cause _____ HINT 4 things |
|
Definition
1. Asptic meningitis 2. Manulopapular & vesciluar rash 3. Conjuntivitis 4. Diarrhea |
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|
Term
| When are Echovirus 1-13 aspectic meningitis more likely to occur |
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Definition
|
|
Term
| Outbreak of diarreha in infants not infected w/ enterobacteria is due to |
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Definition
|
|
Term
| Where would you isolate Echovirus 68 from |
|
Definition
| RT of kids w/ bronchiolitis or pneumonia |
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|
Term
| Echovirus 70 is the chief cause of ________ ________ |
|
Definition
| Hemmorrhagic conjunctivitis |
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|
Term
| Echovirus 71 is a major cause of ___ ______ |
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Definition
|
|
Term
| Symptoms of Echovirus 72 resemble _____ |
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Definition
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|
Term
| How does rotavirus differ form the rest of the enteroviruses |
|
Definition
|
|
Term
| What's the make up of Rotavirus |
|
Definition
1. Icosahedral nucleocapsid 2. Nonenveloped 3. DS segmented |
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|
Term
| Which virus is the single most important world wide cause of _______ _______ |
|
Definition
|
|
Term
| Who is more at risk for contracting Rotavirus |
|
Definition
1. Daycare 2. Hospital 3. Camps |
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|
Term
| Rotavirus is asymptomatic in ______ ______ & _____ |
|
Definition
1. young infants 2. Adults |
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|
Term
| Name the symptoms of Rotavirus infection |
|
Definition
1. Vomiting, diarrhea & low fever 2. Cough & running nose in 50% 3. Dehydration & acidosis |
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|
Term
| Why can Rotavirus be considered life threatening? |
|
Definition
| Can cause dehydration & acidosis |
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|
Term
| How would you detect rotavirus |
|
Definition
|
|
Term
| Name the vaccine for Rotavirus |
|
Definition
|
|
Term
| Rotavirus can be trasmitted by |
|
Definition
|
|
Term
| What part of the GI tract does Rotavirus infect |
|
Definition
| Villus cells of proximal SI |
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|
Term
| Rotavirus is also known as _______ _______ |
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Definition
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|
Term
| Norwalk virus is a _____ ____ ________ |
|
Definition
Later life infection "50% > 50 yrs old" |
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|
Term
| Give the makeup us Norwalk virus. What other virus shares this make up |
|
Definition
1. RNA 2. Icosahedral nucleocapside 3. Nonenveloped 4. (+) ss nonsegmented The other virus is Hep. E |
|
|
Term
| Name the 3 Picornaviridae |
|
Definition
1. Polio 2. Coxsackie 3. Hep A |
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|
Term
| Give the makeup of Piconaviridae |
|
Definition
1. RNA 2. Icosahedral 3. Nonenveloped 4. (+) SS nonsegmented |
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|
Term
| How is Norwalk virus transmitted |
|
Definition
|
|
Term
| Name the symptoms of a Norwalk virus infection |
|
Definition
1. Diarrhea 2. Nausea, vomiting 3. Abdominal pain |
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|
Term
| What's the makeup of Hep A |
|
Definition
1. RNA 2. Iscosahedral nucleocapsid 3. Nonenveloped 4. (+) SS nonsegmented |
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|
Term
| What are the symptoms of Hep A virus |
|
Definition
1. Acute onset of fever 2. Rash 3. Ab. Pain 4. Loss of appettite 5. Jaundance |
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|
Term
| How do you diagnosis Hep A |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What vaccine is available for HAV? |
|
Definition
|
|
Term
| What's different about Hep. B virus from the rest of the Hepatitis viruses |
|
Definition
|
|
Term
| What's the make up of Hep. B virus |
|
Definition
1. DNA virus 2. Icosahedral nucleocapsid 3. Enveloped 4. DS circular |
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|
Term
|
Definition
| Intergrates viral DNA into host and then transcribes HBV RNA and finally uses reverse transcriptase to make DNA |
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|
Term
| What enzyme is used by HBV to repliacte it's DNA? |
|
Definition
|
|
Term
| What's the most common manifestation of HBV |
|
Definition
|
|
Term
| What are the symtpoms of symtpomatic HBV |
|
Definition
1. No fever 2. Long lasting malaise 3. Jaundace |
|
|
Term
| What happens if you consume ALOH if you have HBV |
|
Definition
| Liver cirrhosis & carcinoma |
|
|
Term
| You can get HBV by _____ & contact w/ ______ |
|
Definition
|
|
Term
HBV, HCV & HDV all have HINT 4 |
|
Definition
1. Blood transmission 2. Chronic carrier state 3. Cirrchosis 4. Hepatocellular carcinoma |
|
|
Term
| Which antibody do you use to reveal length of a HBV infection |
|
Definition
Acute: IgM anti-HBcAG Chronic: IgG anti-HBcAG |
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|
Term
| What do you look for in a HBV patient to determine if they contagious |
|
Definition
|
|
Term
| What presence of what antigen determines a HBV infection |
|
Definition
|
|
Term
| A chronic HBV infection can give you ______, & _______ ____________ |
|
Definition
| Cirrohosis & hepatocellular carcinoma |
|
|
Term
| What kind of vaccine is available for HBA |
|
Definition
|
|
Term
| What vaccine is avaiable for HBV |
|
Definition
|
|
Term
| What would you use treat HBV. Why? |
|
Definition
Inferferon alpha Stimulates antibodies to Hep B surface antigen |
|
|
Term
| Which 2 hepatitis viruses are transmitted via fecal-oral |
|
Definition
|
|
Term
| Most of HCV infections are _____ |
|
Definition
|
|
Term
| What's the make up of HCV? What other virus shares this make up |
|
Definition
1. (+) ssRNA nonsegmented 2. Icosahedral nucleocapsid 3. Enveloped 4. Flaviviridae Flavivirus |
|
|
Term
| What do you transmitt HCV |
|
Definition
Sex Percutaneous contact w/ blood |
|
|
Term
| What are the symptoms of HCV |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What's the make up of Hep D Virus |
|
Definition
1. (-) ssRNA "circular" 2. Icosahedral nucleocapsid 3. Enveloped |
|
|
Term
| What's Hep. D virus also known as |
|
Definition
|
|
Term
| Hep D virus codes for 1 ___ that generates two proteins by ___ ____ |
|
Definition
|
|
Term
| What does HDV need to replicate? |
|
Definition
|
|
Term
| In order for somebody to contract HDV what must the have been infected with? |
|
Definition
|
|
Term
| What do you use for prophalyaxis against HDV |
|
Definition
|
|
Term
| What's the make up of Orthmyxoviridae influenzavirus virus |
|
Definition
1. (-) ssRNA 2. Helical nucleocapsid 3. Enveloped |
|
|
Term
| Name the two major proteins on the envelop of influenzae virus |
|
Definition
|
|
Term
| In regards to influenzae, this protein is inside the membrane and is involved in assembly |
|
Definition
|
|
Term
| Influenzae Virus contains a nuclear capside w/ _____ |
|
Definition
|
|
Term
| (-) ssRNA from influenzae has ___ segments |
|
Definition
|
|
Term
| What's a drift when talking about influenza |
|
Definition
| Mutations in HA or NA that results in small changes a |
|
|
Term
| What's a shift when talking about influenzae |
|
Definition
| Complete change in HA or NA |
|
|
Term
| What are the symptoms for the flu |
|
Definition
1. Fever 2. Cough 3. Malasie 4. Loss of appetite |
|
|
Term
| What do you measure in the lab for a influenzae infection |
|
Definition
Hemaggutination inhibition: Measure HA using antibody titers |
|
|
Term
| What does neuraminidase cleave |
|
Definition
|
|
Term
| Neuraminidase (NA) disrupts ______ _____ exposing sialic acid & ______ ______ reducing surfactant |
|
Definition
1. Mucous layer 2. Paralyzing cilia |
|
|
Term
| Neuraminidase is the target for which drugs |
|
Definition
|
|
Term
| What's the function of Hemagglutinin Activity (HA) |
|
Definition
1. Attaches to sialic acid receptors 2. Fuse w/ the cell membrane |
|
|
Term
|
Definition
| Ion channel that facilitates uncoating & assembly |
|
|
Term
| M-protein is the target for which drugs |
|
Definition
| Amantadine and Rimantadine |
|
|
Term
| How does influenzae virus get it's cap for mRNA |
|
Definition
| Snatches it from host mRNA |
|
|
Term
| The flu vaccine has which components |
|
Definition
|
|
Term
| IFN g cases vasodilation & edema resulting in |
|
Definition
1. Rhinorrhea 2. Pharynx, larynx swelling 3. Trachea/bronchi inflammation |
|
|
Term
| What's the makeup for Coronavirus |
|
Definition
1. (+) ssRNA nonsegmented 2. Helical nucelocapsid 3. Enveloped |
|
|
Term
| What protein in coronavirus binds to sialic acid |
|
Definition
|
|
Term
| The (+) ssRNA genome of Coronavirus is ______ & ________ |
|
Definition
|
|
Term
| Why is there a high incidence of muation in Coronavirus |
|
Definition
|
|
Term
| What does coronavirus cause |
|
Definition
|
|
Term
| Give the symptoms of SARS |
|
Definition
1. Fever about 38 C 2. Headache 3. Maliase 4. Aches 5. Non-productive cough |
|
|
Term
| How many ORF are there in SARS? How many of them are unique to SARS |
|
Definition
|
|
Term
| What's the classical diagnosis of SARS |
|
Definition
| Travel w/in 10 days of onset of symptoms to an area documented to have SARS or come in close contact w/in 10 days to a person w/ SARS |
|
|
Term
| Which protein in SARS is responsible for membrane fusion |
|
Definition
|
|
Term
| Which protein in SARS gives it hemagglutinating ability |
|
Definition
|
|
Term
| The HE protein in SARS has ______ activity cleaving ____ ____ |
|
Definition
|
|
Term
| Give the make up of Parainfluenza virus. What other viruses share it |
|
Definition
1. (-) ssRNA non-segmented 2. Helical nucleocapsid 3. Enveloped |
|
|
Term
| RSV is also known as ________ ______ |
|
Definition
| Paramyxoviridae Penumovirus |
|
|
Term
| Parainflu. 1 & 2 cause ______ |
|
Definition
|
|
Term
| Parainflu 3 cause _________ & ________ |
|
Definition
| Bronchiolitis & Pneumonia |
|
|
Term
| What season would you find Parainfluenzae 1 & 2 |
|
Definition
|
|
Term
| Parainfluenzae 3 is a ________ infection |
|
Definition
|
|
Term
| What does the HN envelop protein do in Parainfluenze |
|
Definition
|
|
Term
| How does Parainfluenzae penetrate? |
|
Definition
| Requires cleavage of F protein by host enzyme |
|
|
Term
| How do you treat Parainfluenzae, RSV & rhinovirus? |
|
Definition
Supportive Reduce fever Anti-histamines Anti-inflammatory |
|
|
Term
| Ribavirin inhibits ___ replication |
|
Definition
|
|
Term
| Give the make up of Rhinovirus |
|
Definition
1. (+) ssRNA 2. Icosahedral nucleocapsid 3. Nonenveloped |
|
|
Term
| At what temperature does Rhinovirus repliacte the best at |
|
Definition
|
|
Term
| What are the symptoms of the common cold |
|
Definition
1. Sneezing 2. Sore threat 3. Nasal discharge |
|
|
Term
| what's the incubation period of Rhinovirus |
|
Definition
|
|
Term
| Where is the respiratory tract is rhinovirus localized to |
|
Definition
|
|
Term
| Rhinovirus is seasonal, you would most likely find it in late ____ to ___ & ____ to _____ |
|
Definition
|
|
Term
| What season would you find corona virus |
|
Definition
|
|
Term
| Rhinovirus attaches via _____ or ___ in post nasal pharynx |
|
Definition
|
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