Similarities

1.  Gram (-)

2.  Lactose Fermenters

Differences
E. coli is indole (+)

ETEC

Vibro Cholera

P.aeruginosa 

Heat labile toxin (LT):

1.  ADP ribosylates Gs

2.  Elevates cAMP

3.  Cells secrete Cl-
4.  Absorb less Na+

5.  Watery diarrhea

Heat stable toxin (ST)

1.  Increase cGMP

2.  Decrease cotransporter of Na/Cl 

Where in the GI tract does EPEC adhere to?  

1.  Infantile diarrhea

2.  Watery diarrhea 

Symptoms: 

1.  Hemorrhagic colitis

2.  Bloody diarrhea 

Modes of transmission:

1.  Unpasterized Milk

2.  Undercooked beef 

SLT:

1.  Inactives ribosome 60s

2.  Blocks protein synthesis

Produce H2S:

S. typhi

S. enteritidis

Do not produces H2S:

S. Dysenteriae

Contracted by Fecal oral

Presents:

Typhoid fever:

1. high temperature, constipation or dirrahea

2.  Rose spots (Red spots on the stomach) 

3.  Enlarged spleen 

4.  Hides out in the gall bladder and reinfects peyer patches and leads to bloody diarrhea

Contract:

1.  Fecal oral

2. Zoonosis (turtles)

Present:

1.  Rotten egg smelling dirrhea

2.  Fever, cramping, vomiting 

Similarities:

1.  gram (-)

2.  Lactose non-fermenting

3.  Oxidase (+)

Differences

V. chlorae:  glucose fermenter

P. aeruginosa:  non-glucose fermenter 

How do you get  V. chloerae and how does it present?

Contract: 

1.  Fecal oral

2.  Contaminated water

 Present:

1.  Rice water stool 

AB toxin

A.  ADP ribosylates

1.  Increase cAMP

2.  Increase Cl- in the lumen

3.  Less Na+ is absorbed

4.  Water in the lumen (dirrhea)

B.:  binds to ganglioside GM1 on epithelial cells in the small intestine 

Live oral vaccine

1.  Delection of A subunit

Mixed whole killed cell

1.  Contains B subunit 

1.  Rehydrate w/ salts

2.  Tetracycline 

Contract:

1.  Shellfish

Presents:

1.  Diarrhea

2.  Cramps, nausea, fever and vomiting 

Contract:

1.  fectal-oral 

Presents:

1.  Bloody dirrhea

2.  Fever

1.  Day-care

2.  Mentally retarded 

1.  Distal colon

2.  Destroys cells

3.  Ulceration and production of pus 

1.  chloera like

2.  inactives 60s ribosome 

3.  Inhibits protein synthesis 

Gastroenteritis

1.  Blood and pus in stool

2.  Severe ab. Pain, fever