Shared Flashcard Set

Details

Micro
Week 3b - Viral genetics, pathogenesis, & some pharm :(
7
Accounting
Pre-School
03/14/2013

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Cards

Term
What is genome reassortment? Which virus families can do it?
Definition
-RNA exchange between related viruses
-Only the viruses with segmented RNA can do it (all -RNA); arena, bunya, roe, & orthomyxo
Term
What is complementation?
Definition
-When viral gene or proteins rectify a defect in a related virus
-Can turn a latent infection pathogenic
Term
What is phenotypic masking/mixing?
Definition
-When you have different glycoproteins on the capsid (like polio 1 with a polio 2 capsid)
Term
Define;
-Horozontal spread
-Vertical spread
-Arboviruses
-Zoonosis
-Iatrogenic
Definition
-Horozontal spread; person to person
-Vertical spread; mother to child
-Arboviruses; insects carry
-Zoonosis; spread by animals
-Iatrogenic; from medical practice
Term
How do we treat herpes viruses? What do they target?
Definition
-With **acyclovir (all) or gancyclovir (for CMV)
-Target viral *thymidine kinase and viral *DNA pol
Term
What is foscarnet?
Definition
-Drug for CMV retinitis
-Can also block HIV RT
-It is a phosphate analog
Term
Start back at 23
Definition
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