Term
| man presents w/ thin, watery penile discharge w/ pain upon urination |
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Definition
| C. trachomatis - chlamidia |
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Term
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Definition
chlamidia - infectious form; attaches to epithelial cells;
becomes reticular body in phagosome |
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Term
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Definition
Coxiella burnetti - lives in phaggosome; activatd w/ low pH;
flu-like; endocarditis |
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Term
| rocky mountain spotted fever |
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Definition
ricketsia - hijacks actin system to evade immunity
rash, eschar;
MUST treat quickly (presumptively) |
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Term
| oxidase-producing bacteria |
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Definition
virbrio - cholera, vunificus, parahemolyticsu;
bile-salt resistance - can live in GI tract |
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Term
| thiosulfate citrate bile salts-sucrose |
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Definition
| media required for isoloation of vibros |
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Term
| liver disease predisposes to what disease? |
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Definition
| sepsis syndrome - virbrio (usually due to consumption of raw fish) |
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Term
| toxin-corregulated pilus (TCP) |
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Definition
| vibrio cholera - uses for adhesion to epitelium (esp sm intestine) |
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Term
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Definition
| helps w/ motility of V. cholera |
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Term
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Definition
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Term
| what bacteria requires host calmodulin? why? |
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Definition
| calmodulin-biding domain of the adenylate cyclase toxin of B. pertussis - increases cAMP - increases mucous (also has AB toxin w/ same effects) |
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Term
| what's the MAJOR mech through which B. pertussis causes disease? what are the other 2 mechs? |
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Definition
Tracheal Cytotoxin - endotoxin; toxic to ciliated tracheal cells - collaberates w/ LPS to induce IL-1 and Nitic Oxide Synthase (both pro-inflammatory); other 2 - AB toxiin and Adenylate cyclase - similar mech - increase cAMP - increase mucous |
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Term
| infant, 3d after birth, has conjunctivitis and mild pneumonia |
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Definition
| C. trachomatis (mom has chlamedia) |
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Term
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Definition
Campylobacter jejuni
post-gastroenteric disease sequale |
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Term
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Definition
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Term
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Definition
| armor plate of Campylobacter fetus that protects against complement and Ab deposition |
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Term
| urease-producing bacteria |
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Definition
| helicobacter and brucella |
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Term
| LPS that produces epitopes similar to RBC Lewis Ag (thus avoiding immunity) |
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Definition
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Term
| Cag A (cytotoxin associated gene) |
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Definition
virulence island in many H. pylori
presence correlates w/ peptic ulcer |
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Term
| VacA (vacuolating cytotoxin) |
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Definition
| immunosuppressive molecule - downregulates T cells; this is a virulence factor of Helicobacter |
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Term
| what's a zinc-dependent toxin |
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Definition
| botulism and tetanus (A subunit) |
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Term
| honey is often implicated in what poisoning in little kids? |
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Definition
| C. botulism (comes in w/ spores) |
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Term
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Definition
clostridium perfinges: gas gangrene, aerobic cellulitis, food poisoning;
phospholipase - hydrolyzes lecithin and sphingomyelin of cell membrane, thus causing lysis |
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Term
| what bacteria produces a lot of gas |
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Definition
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Term
| Rho proteins - what do they do? what bacteria acts on them? in what way? |
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Definition
| regulates actin polymerization, and thus cytoskeletal integrity. C. deficille has 2 toxins - A and B (10x more potent) - that glycosylate and thus inactivate Rho |
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Term
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Definition
Corynabacterium diptheria;
cell debris, fibrin, inflammatory cells, bacteria in throat |
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Term
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Definition
| encodes a protein secretion system in MTB |
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Term
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Definition
| occurs if pt lacks immunity - dissemminated MTB infection - lots of small granulomas |
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Term
| what bacterium lacks cell wall? why important? associated w/ what disease? |
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Definition
Mycoplasma penumoniae.
Resistant to cell wall antibiotics.
Leading cause of atypical pneumoniae. |
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Term
| charcoal-containing media |
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Definition
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Term
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Definition
Borrelia burgdorgeri (lyme) starts producing this when tick starts to feed.
Attaches to tick's salivary protein, which then helps protect it against mammalian complement. |
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Term
| plasminogen is involved in pathogenesis of what bug? how? |
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Definition
| borrelia burdorgeri (lyme) - promotes penetration of midgut epithlium in the tick, and thus its systemic infection |
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Term
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Definition
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Term
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Definition
| autoimmune - dermatitis, conjunctivitis; C. trachomatis and Salmonella |
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Term
| unpasturized dairy - risk for what disease? organism? |
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Definition
undulent fever (brucellosis);
Brucella |
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Term
what malaria only shows ring forms of parasites in peripheral RBCs?
what other morphologic feature is unique here? |
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Definition
P. falciparum;
crescent-shaped gametocytes |
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Term
| what infection can a pregnant woman acquire from cat litter |
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Definition
Taxoplasma Gondii - tissue protozoa;
Congenital Taxoplasmosis - retardation, part of TORCH syndrome, ocular taxoplasmosis |
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Term
| which worm is Dxed w/ a muscle biopsy |
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Definition
| Trichinell (tissue nematode) |
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Term
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Definition
| zygomycosis - rhinocerebral mucormycossis (black lesions in face, sinuses) in ketoacidotic diabetics |
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Term
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Definition
| ETEC - heat lavile toxin and heat stabile toxin |
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Term
| the only fungus w/ a capsule |
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Definition
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