Term
|
Definition
Borrelia, Leptospira, Treponema
Syphilis from BLT |
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Term
| How to visualize spirochetes |
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Definition
| Dark-field microscopy, they don't stain good. pallidum > silver nitrate |
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Term
| Treponema pertenue (yaws) and Treponema carateum (pinta) cause what? |
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Definition
| non-vd chronic skin lesions. Happens in the tropics. |
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Term
| Treponema pallidum causes? |
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Definition
|
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Term
|
Definition
| 1. Painless chancre 2. Rash 3. CV and CNS lesions>typically non-contagious |
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Term
| Syphilis (pallidim) diagnosis? |
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Definition
| Ab test. Relatively unreliable, must use f/u test specific for palidim |
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Term
| What does Borrelia recurrentis cause? |
|
Definition
Louse-borne relapsing fever.
(Cyclic rise and fall of temp, d/t transient evasion of immune sys. by mutation) |
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Term
| Borrelia burgdorferi causes what? |
|
Definition
Lyme disease.
Presents w/ skin lesions and arthritis |
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Term
| Borrelia vincentii causes? |
|
Definition
A.N.U.G.
Acute Necrotizing Ulcerative Gingivitis
Acute necrotizing ulcerative gingivitis |
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Term
| Leptospira interrogans symptoms |
|
Definition
| Sepsis, localizes in kidney. Hemorrhage, jaundice, and azotemia. |
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Term
| Antibiotic effective against most spirochetes? |
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Definition
|
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Term
| Louse-borne vs tick-borne relapsing fever transmission |
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Definition
Louse-borne: Person>louse>person
Tick borne: Animal reservoir(rodents)>humans. |
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Term
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Definition
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Term
| Relapsing Borrelia fever disease presentation |
|
Definition
| Sudden onset of chiulls, fever, HA, myalgias, emesis, diarrhea.>recovery?relapse (x2-3, maybe 13) |
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Term
| Relapsing fever micro stains |
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Definition
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Term
| Lyme disease Gen features |
|
Definition
Rodent/pet>transfers tick to human.
3-30 days incubation
>lesion @ bite site.
>red flat border, central clearing
>called erythema chronicum migrans.
Early disease also associated w/ flu-like sx |
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Term
| Advanced Lyme disease features |
|
Definition
| Neuro, and cardio sx>>Arthralgias and arthritis. |
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Term
| Detecting Lyme spirochetes (Borrelia burgdorferi) |
|
Definition
Don't stain well.
>Serologic tests.
>late in Dz, few spirochetes present, sx largely d/t immune response>cross rxn. |
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Term
| Borrelia vincentii (ANUG) AKA. Vincent's infection, Sx |
|
Definition
inflammation/necrosis of gingiva.
Gram negative >anaerobic bac (fungospirochetal complex). |
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Term
|
Definition
| Stress, anxiety, negligent oral hygeine |
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Term
|
Definition
Infectious jaundice, Weil's disease, and Canicola fever.
Signs and Sx: chills, fever, HA, pphotophobia, GI, myalgias. Hemorrhage, jaundice, and azotemia=far progression and poor prognosis. |
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Term
|
Definition
| Easily cultered on animal serum media. Obligate aerobes. |
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Term
|
Definition
| Leptospira interrogans. Three pathogenic serotypes: Pomona (pig), Canicola (dog), icterohaemorragiae (rat). |
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Term
| Organs affected by leptospirosis |
|
Definition
| Meninges, lungs, liver, kidney |
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Term
|
Definition
Specimen under darkfield microscopy
Blood and CSF-week 1
Urine- after 1 week
Culture:
Fletcher's medium.
Same samples
3. Microscopic agglutination to detect Ab to microbe in serum |
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Term
|
Definition
| ABX effective in early stages. Prognosis has inverse relationship w/ jaundice. |
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