Term
| Monophosphorylated by viral thymidine kinase, guanisine analog, inhibits viral DNA POLYMERASE |
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Definition
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Term
|
Definition
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Term
| This drug does not have hemolytic properties |
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Definition
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|
Term
| Virus changes viral thymidine kinase providing resistance to |
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Definition
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Term
| This drug is a guanisine analogue, forms 5 monophsphate inhibiting DNA polymerase |
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Definition
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Term
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Definition
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Term
| Gancyclovir resistant CMV or CMV retinitis |
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Definition
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Term
| Herpes drug with Bone Marrow suppression and renal toxicity |
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Definition
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Term
| inhibits both RNA and DNA polymerases |
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Definition
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Term
| Binds to pyrophosphate binding site and inhibits DNA |
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Definition
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Term
| Herpes drug which is Nephrotoxic but is not hematotoxic, so good in patients with BM suppression |
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Definition
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Term
| Blocks uncoating/penetration of influenza |
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Definition
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Term
| Tx or prophylaxis for Flu A only |
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Definition
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Term
| MOA of Amantadine for Parkinsons |
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Definition
| Anticholinergic (atropine like) allows for more dopamine release. |
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Term
| Resistance to Amantadine by what |
|
Definition
| M2 protein (90% of all flu A) |
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Term
| Inhibits neuraminidase decreasing release of Flu A or B from the cell |
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Definition
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|
Term
| What are the side effects of zanamivir |
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Definition
|
|
Term
|
Definition
Zidovudine
Didanosine
Stavudine
Lamivudine
Emtricitabine
Abacavir |
|
|
Term
| inhibit addition of nucleoside and terminates the DNA chain. Must be phophorylated to thymidine kinase |
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Definition
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|
Term
|
Definition
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Term
| Drug used for prophylaxis for pregnancy in HIV |
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Definition
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|
Term
Sides of:
1. Zidovudine
2. Didanosine
3. Stavudine |
|
Definition
1. Bone Marrow suppression, peripheral neuropathy, lactic acidosis, Megablastic anemia
2. Pancreatitis
3. Myelosuppression |
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|
Term
| What is the MOA of NNRTIs and what are the 3 examples |
|
Definition
Bind to reverse transcriptase and do not require phosphorylation
1. Efavirenz
2. Nevirapine
3. Delavirdine |
|
|
Term
| NRTI (nucleotide): what are 2 examples |
|
Definition
Tenofovir/Adefovir
do not need to be phosphorylated |
|
|
Term
| What are NNRTIs synergistic with |
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Definition
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|
Term
| Protease inhibitors inhibit the maturation of what HIV gene |
|
Definition
|
|
Term
| What are the Protease inhibitors |
|
Definition
Saquinavir
Ritinavir
Indinavir
Nelfanavir |
|
|
Term
| Resistance and sides of protease inhibitors |
|
Definition
Pt mutation at pol gene
Inhibitors of P450, hyperglycemia, GI intolerance |
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|
Term
| Inhibits integration into host cell chromosomes |
|
Definition
| Integrase inhibitors (Raltegravir) |
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|
Term
| Inhibits Guanine nucleotide by competitively inhibiting IMP dehydrogenase |
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Definition
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|
Term
|
Definition
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|
Term
|
Definition
| Hemolytic anemia and teratogenic |
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|
Term
| Herpes drug which inhibits DNA polymerase and is used for acyclovir resistant HSV |
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Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
| Fusion inhibitor of the gp41 binding protein on HIV |
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Definition
|
|
Term
| Drugs which effect RNA polymerase |
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Definition
|
|
Term
|
Definition
| Binds ergosterol, forms pores that allow leakage of electrolytes |
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|
Term
|
Definition
|
|
Term
| Major toxicity of Amphotericin B |
|
Definition
Nephrotoxic
Also anemia, arrhythmia, IV phlebitis, |
|
|
Term
| How is Amphotericin B used for meningitis |
|
Definition
|
|
Term
| Amphotericin B can be used for what microbes |
|
Definition
Cryptococcus
Blastomyces
Coccidioides
Aspergillus
Histoplasma
Candida
Mucor
N. Fowleri |
|
|
Term
|
Definition
| Swish/swallow for oral candidas,diaper rash, vaginal |
|
|
Term
|
Definition
| Inhibit fungal sterol synthesis converting lanosterol to ergosterol |
|
|
Term
| What azole can cross the BBB |
|
Definition
|
|
Term
| Flucytosine is used to treat _____with what other drug |
|
Definition
| Cryptococcal meningitis and Amphotericin B |
|
|
Term
|
Definition
| Gycocomastia, P-450 inhibitors, liver dsfxn, decreased absorption with antacids |
|
|
Term
| What is the resistance to azoles |
|
Definition
|
|
Term
|
Definition
| Inhibits DNA synthesis by conversion to 5-flourouracil by cytosine deaminase |
|
|
Term
| Major complication of Flucytosine |
|
Definition
|
|
Term
|
Definition
Inhibits cell wall synthesis by inhibiting synthesis of B-glucan
Invasive Aspergillosis and Candida |
|
|
Term
| Terbinafine inhibits what and is used against what microbes |
|
Definition
| squalene epoxidase/Dermatophytes |
|
|
Term
|
Definition
| Microtubule fxn, disrupts mitosis |
|
|
Term
| Where does Griseofulvin deposi |
|
Definition
|
|
Term
| Griseofulvin used against what |
|
Definition
|
|
Term
| Griseofulvin is a P450___________ |
|
Definition
| inhibitor and is teratogenic and carcinogenic |
|
|
Term
|
Definition
| Pyrimethamine/sulfadiazine |
|
|
Term
|
Definition
|
|
Term
Used for T. Brucei
1. blood
2. CNS |
|
Definition
1. Suramin
2. Melarsoprol |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| tx for Plasmodium ovale and vivax |
|
Definition
|
|
Term
| tx for resistant plasomdium |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Cestodes and trematodes tx |
|
Definition
| Praziquantel except echinococcus (bendazoles) |
|
|
Term
|
Definition
|
|
Term
| Loa Loa, wicheria bancrofti, and toxacara canis tx |
|
Definition
|
|
Term
| Dracunculus medinensis tx |
|
Definition
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|
