Term
| Hepatitis A - E, tropism for? |
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Definition
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Term
| Hep A: transmission route? |
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Definition
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Term
| Hep B: transmission Route |
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Definition
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Term
| Hep C: transmission Route |
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Definition
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Term
| Hep D: Transmission Route |
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Definition
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Term
| Hep E: Transmission Route |
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Definition
| Fecal Oral transmission Route |
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Term
Hep A profile:
Virus type?
Strand?
Envelope?
Shape? |
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Definition
Picorna virus (small RNA)
single stranded
naked
icosahedral |
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Term
| Epidemiology of Hep A is related to? |
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Definition
| Sanitation levels, because it is a fecal oral transmission. Common in developing nations. |
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Term
| Where does Hep A replicated and how does it get to the liver? |
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Definition
| Virus is ingested, replicated in the bowel and then spreads to the liver via the blood stream. |
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Term
| Incubation period for Hep A |
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Definition
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Term
| Does Hep A produce chronic carrier state? |
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Definition
| No chronic carrier state. |
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Term
| Confirmed diagnosis of Hep A? |
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Definition
| Appearance of IgM antibodies. |
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Term
| Signs and Symptoms of Hep A? |
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Definition
| Most cases are asymptomatic. Jaundice is only rare. |
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Term
| Can you get Hep A more than once? |
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Definition
| No, develop antibodies to it. |
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Term
| Titer for the Hep A - serologic course? |
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Definition
| High viral load(symptoms, abnormal liver tests), antibodies start to be produced at around 2 months and viral load decreases. IgM at first IgG for the rest of your life. |
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Term
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Definition
| Vaccine, Immune globulin (gives instant protection for exposure prophylaxis). |
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Term
Hep B Profile:
Virus Type? |
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Definition
| Double stranded DNA virus |
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Term
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Definition
| Yes, may be chronic active or persistent hepatitis. Can lead to liver cancer. |
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Term
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Definition
| Very infectious. 20% of needlesticks result in infection in non immune individuals. |
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Term
| Factors that affect carrier state? |
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Definition
| Age, young are more likely to become chronic carriers. |
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Term
| Consequences of Chronic Hep B? |
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Definition
No/minimal liver injury or
Chronic active hepatitis
Cirrosis of the liver (liver failure, portal hypertension)
Hepatocellular carcinoma |
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Term
| Hep B geographic distribution? |
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Definition
| High in developing nations, among native and northern populations in Canada. |
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Term
| Acute Hep B with recovery serologic course? |
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Definition
Virus appears in blood stream after a month, develop antibodies, virus disappears, develop MEMORY antibodies.
HBsAG - Surface antigen, protein on capsomere. |
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Term
| Chronic Hep B infection serologic course? |
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Definition
| Infection, virus appears in blood stream and stays for the rest of your life. No antibody to surface antigen. Infectious for the remaining course of your life. |
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Term
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Definition
Pos exposure prevention vaccination. HBIG collected from people that have high levels of HBV.
Vaccine (surface antigen) - universal for kids, and others at risk.
Baby is vaccinated right away if mother is carrier. |
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Term
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Definition
| interferon and lamividine in chronic patients. |
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Term
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Definition
Detection of surface antigen in blood.
Detection of antibodies to Hep B surface Ag.
Liver biopsy to determine the extent of liver damage. |
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Term
Hep C Profile:
Type of virus?
Who gets infected?
Envelope?
Shape? |
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Definition
small RNA virus
IV drug users are commonly infected, less infectious for needle stick.
enveloped
Icosahedral. |
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Term
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Definition
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Term
| Hep C, how many get liver disease? |
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Definition
| 40-60% get liver disease, higher than Hep B. |
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Term
| Can you become a chronic carrier of Hep C? |
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Definition
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Term
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Definition
| Infection, symptoms 2-3 months after infection, antibodies develop at 4-5 months and viral load declines. antibodies in the blood don't control the virus, leads to spikes. |
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Term
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Definition
Screening for antibodies,
confirm with PCR, and immunoblot assay. |
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Term
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Definition
| No vaccine and none on the way. Good public health helps prevent it (screening for blood, organ donor screening, needle exchange programs). |
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Term
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Definition
Interferon and ribavirin results in cure in over 60% of people.
Interferon has side effects. |
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Term
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Definition
Interferon and ribavirin results in cure in over 60% of people.
Interferon has side effects. |
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Term
Hep D Profile:
Prevalence?
How do you get it?
Population most at risk? |
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Definition
Very rare - incomplete RNA virus that requires the presence of Hep B.
Get it at the same time or after infection with Hep B.
IV drug users. |
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Term
Hep E Profile:
Prevalence?
Similar to?
Transmission?
Chronic? |
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Definition
Very rare in NA.
Similar to Hep A
Fecal Oral spread
No chronicity
Low fatality. |
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