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Micro buzzwords
All micro buzzwords for step 1
328
Microbiology
Graduate
04/10/2013

Additional Microbiology Flashcards

 


 

Cards

Term
Bacillary angiomatosis
Definition
Bartonella henselae
Term
“Black poison”
Definition
Visceral Leishmaniasis
Term
Blackwater fever
Definition
malaria
Term
Blueberry muffin baby
Definition
Rubella
Term
Break-bone fever
Definition
Dengue
Term
Bull’s-eye rash
Definition
Lyme disease Borrelia burgdorferi
Term
Downey cell (atypical lymphocyte)
Definition
EBV, CMV
Term
Eggs with lateral spine
Definition
Schistosome mansoni
Term
Eggs with terminal spine
Definition
Schistosome haematobium
Term
Heterophile antibody
Definition
EBV
Term
Hypnozoite
Definition
P. vivax
Term
Maltese cross
Definition
Babesia spp
Term
Morula
Definition
Ehrlichia and Anaplasma
Term
Owl’s-eye inclusion
Definition
CMV
Term
Rabbit fever
Definition
Francella Tularemia
Term
Rash on hands/feet spreads to trunk
Definition
Rocky Mountain spotted fever (Rickettsia rickettsii)
Term
Ring forms inside RBCs
Definition
P. falciparum:
Term
Romaña sign
Definition
T. cruzi:
Term
Safety-pin (bipolar) staining
Definition
Yersinias pestis
Term
Sausage-shaped gametocyte
Definition
P. falciparum:
Term
Schuffner dots
Definition
P. vivax, P. ovale
Term
Rash on trunk that goes outwards
Definition
R. prowazeki
Term
Rustic log cabin
Definition
Relapsing fever: Borrelia recurrentis
Term
Hawaii and surfing
Definition
Leptospira interrogans
Term
Organism w/ hooked ends
Definition
Leptospira interrogans
Term
sandfly
Definition
Leishmania Bartonella bacilliformis
Term
Broad-based budding yeast
Definition
Blastomyces
Term
Bull neck
Definition
Corynebacterium diphtheriae
Term
Catcher’s stance
Definition
Haemophilus influenza type B
Term
Cherry red epiglottis
Definition
Hemophilus influenzae
Term
Cold-agglutinin positive
Definition
Mycoplasma pneumoniae
Term
Consumption
Definition
Old name for Tuberculosis
Term
Cottage-cheese granuloma
Definition
Mycobacterium tuberculosis
Term
Currant jelly sputum
Definition
Klebsiella pneumoniae
Term
Dented helmets
Definition
Pneumocystis jiroveci (PCP)
Term
Downey cell
Definition
Herpes virus causing pharyngitis, Epstein-Barr virus: heterophile positive; Cytomegalovirus: heterophile negative
Term
Farmer’s lung
Definition
Allergic aspergillosis/hypersensitivity pneumonitis, Thermophilic Actinoyces spp.; Acute damage by cytokines, type III HSR, may be type IV also
Term
Fungal ball
Definition
Aspergillosis (aspergilloma)
Term
Grape-like smell in culture
Definition
Pseudomonas aeruginosa
Term
Green sputum in cystic fibrosis patient
Definition
Pseudomonas aeruginosa
Term
Grows on chocolate agar, not on blood agar
Definition
Haemophilus influenza
Term
Heterophile antibody-positive
Definition
Epstein-Barr virus
Term
Kidney bean-shaped diplococci
Definition
Neisseria gonorrhoeae
Term
Koplik spot
Definition
Measles – paramyxovirus, negative sense, ssRNA, enveloped helical
Term
Lancet-shaped diplococci
Definition
Streptococcus pneumonia
Term
Many PMNs in sputum, no organisms seen
Definition
Atypical pneumonia: M. pneumonia,
Term
Mediastinal widening
Definition
Bacillus anthracis
Term
Nonfermenter
Definition
Acinetobater, Bordatella, Burkholderia, Legionella, Moraxella, Pseudomonas
Term
Owl’s eye inclusion
Definition
CMV: heterophile negative
Term
Parrot fever
Definition
Chlamydophila psittaci
Term
Pilot’s wheel
Definition
Paracoccidioides brasiliensis
Term
Rabbit fever
Definition
Francisella tularensis, buffered charcoal yeast agar, cysteine glucose blood agar
Term
Rust-colored sputum
Definition
Streptococcus pneumonia, Paragonimus westermani (lung fluke) – sputum will also have parasitic eggs
Term
Anaplasma phagocytophilum
Definition
Ixodes ticks
Term
Babesia microti
Definition
Black legged tick (Ixodes tick)
Term
Borrelia burgdorferi
Definition
•Vector: tick: Ixodes scapularis
Term
Dengue virus
Definition
•Vector: Aedes mosquito.
Term
Loa loa
Definition
Chrysops fly
Term
Onchocerca volvulus
Definition
Female blackflies
Term
Plasmodium species
Definition
Mosquito (Anopheles)
Term
Rickettsia prowazekii
Definition
•Vector: human body louse and fleas
Term
Rickettsia rickettsii
Definition
•Vector: Rocky mounted wood tick (D. andersoni)
Term
Trypanosoma brucei
Definition
Tsetse fly
Term
Trypanosoma cruzi
Definition
Vector: reduviid (triatomine) bugs, aka kissing-bug
Term
West Nile virus
Definition
Mosquito
Term
Yellow fever virus
Definition
•Vector Aedis aegypti mosquito
Term
Yersinia pestis
Definition
Flea transmit it to prairie dogs and rodents
Term
Bartonella bacilliformis
Definition
Sandfly
Term
Borrelia recurrentis
Definition
Human body louse
Term
Brugia malayi
Definition
mosquito
Term
Chikungunya virus
Definition
Aedes mosquito
Term
Crimean-Congo hemorrhagic fever
Definition
ticks
Term
Ehrlichia chaffeensis
Definition
Vector: black legged deer tick
Term
Francisella tularensis
Definition
Rabbits
Term
Japanese encephalitis virus
Definition
Mosquito
Term
Leishmania braziliensis
Definition
Sandfly
Term
Leishmania donovani
Definition
Sandfly
Term
Orientia tsutsugamushi
Definition
•Vector: mite (chigger)
Term
Rickettsia akari
Definition
•Vector: mites
Term
Rickettsia typhi
Definition
Vector flea
Term
Rift Valley fever
Definition
mosquitos
Term
St. Louis encephalitis virus
Definition
•Vector: Culex mosquito
Term
Wuchereria bancrofti
Definition
mosquito
Term
Bartonella quintana
Definition
•Vector: body louse (humans in over crowded situations)
Term
Acid fast oocyst
Definition
Cryptosporidiosis (C. parvum), Cyclospora cayetanensis (NOT common)
Term
Elliptical Acid fast oocyst
Definition
Isospora belli
Term
Barrel shaped (football shaped) eggs with plugged ends
Definition
Whipworm: Trichuris trichiura
Term
Beaver fever
Definition
Giardia lamblia
Term
Black vomit
Definition
Yellow fever
Term
Chronic diarrhea in AIDS patient
Definition
Cryptosporidiosis (C. parvum)
Term
Clay pipestem fibrosis
Definition
S. mansoni
Term
Colorless colonies on SMAC agar
Definition
Enterohemorrhagic E. coli (EHEC)
Term
Constipation
Definition
S. typhi,, Clostridium botulinum
Term
Cysticercosis
Definition
Pork Tapeworm: Taenia solium
Term
Dane particle
Definition
Hepatitis B Virus (HBV)
Term
Flask-shaped lesions
Definition
Entamoeba histolytic
Term
Floppy baby syndrome
Definition
Clostridium botulinum
Term
Gastric cancer
Definition
Helicobacter pylori
Term
Growth at 4oC
Definition
Listeria monocytogenes, Yersinia enterocolitica
Term
Growth at 42oC
Definition
Campylobacter jejuni
Term
HUS
Definition
Enterohemorrhagic E. coli (EHEC), Shigella
Term
Hydatid cyst disease
Definition
Echinococcus granulosus, E. multilocularis
Term
Malabsorption syndrome
Definition
Tropheryma whippelii, Giardia lamblia, Isospora belli, Giant Intestinal Fluke: Fasciolopsis buski
Term
Petting zoos
Definition
Enterohemorrhagic E. coli (EHEC)
Term
Pseudoappendicitis
Definition
Yersinia enterocolitica
Term
Megaloblastic anemia
Definition
Fish Tapeworm: Diphyllobothrium latum
Term
Montezuma's revenge
Definition
Enteroinvasive E. coli (ETEC)
Term
Operculum
Definition
Cestodes: Tapeworms, Trematodes: Fluke
Term
Oval-shaped eggs with lateral spine
Definition
Schistosome mansoni
Term
Proglottids
Definition
Cestodes: Tapeworms
Term
Pseudomembranous colitis
Definition
Clostridium difficile
Term
Rectal prolapse
Definition
Whipworm: Trichuris trichiura
Term
Rice water diarrhea
Definition
Vibrio cholerae
Term
Rose spots
Definition
Typhoidal Salmonella
Term
Seagull wings
Definition
Campylobacter jejuni
Term
Scotch tape prep
Definition
Pinworm: Enterobius vermicularis
Term
Sushi worm
Definition
Anisakiasis: Anisakis simplex
Term
Whipple disease
Definition
Tropheryma whipplei.
Term
Reptiles: turtles (snakes, lizards)
Definition
Non-typhoidal Salmonella
Term
Gas gangrene. Bronze colored blisters
Definition
Clostridium perfringens
Term
“Falling leaf motility”
Definition
Giardia lamblia
Term
Bilobed nucles
Definition
Giardia lamblia
Term
knobby-coated, oval-shaped, bile-stained Eggs
Definition
Roundworm: Ascaris lumbricoides
Term
Broad-based budding yeast
Definition
Blastomyces dermatitidis
Term
CAMP-positive
Definition
Group B strep or listeria
Term
Cold selection
Definition
Listeria monocytogenes
Term
Encapsulated yeast
Definition
Cryptococcus neoformans
Term
Floppy baby
Definition
C. botulinum
Term
Grows on chocolate agar, not on blood agar
Definition
Haemophilus
Term
Home canning
Definition
C. botulinum
Term
India ink stain
Definition
Cryptococcus neoformans
Term
K1 capsular antigen
Definition
E. coli
Term
Kidney-bean shaped diplococci
Definition
N. meningitidis
Term
Koplik spots
Definition
Rubeola virus
Term
Lancet-shaped diplococci
Definition
pneumococcal
Term
Negri body
Definition
Rabies virus
Term
Neurocysticercosis
Definition
Taenia solium
Term
Owl’s-eye inclusion
Definition
CMV
Term
Pink eye
Definition
Adenovirus
Term
Positive VDRL/RPR test
Definition
Neurosyphilis
Term
Ring-enhancing lesions
Definition
Toxoplasmosis
Term
Sausage-shaped gametocyte
Definition
P. falciparum
Term
Spherule
Definition
Coccidioides immitis
Term
Temporal lobe encephalitis
Definition
HSV
Term
Tzank smear
Definition
HSV
Term
Waterhouse-Friedrichsen
Definition
N. meningitidis
Term
Weakly acid fast branching rods
Definition
Nocardia
Term
Eggs with terminal spine
Definition
S. haematobium
Term
Germ tubes
Definition
Candida albicans
Term
Honeymoon cystitis
Definition
Staphylococcus saprophyticus
Term
“Lumpy, bumpy” staining
Definition
Deposits of IgG along GBM
Term
Pap-pili
Definition
E. coli
Term
Swarming
Definition
Proteus mirabilis
Term
Uncomplicated hematuria in young boy
Definition
Adenovirus
Term
Beefy red ulcers
Definition
Klebsiella granulomatis
Term
Clue cell
Definition
Bacterial vaginosis
Term
Condylomata lata
Definition
Secondary syphilis (treponema pallidum)
Term
Copper-colored rash
Definition
Secondary syphilis (treponema pallidum)
Term
Cottage cheese discharge
Definition
Vulvovaginal candidiasis
Term
Dew drops on a rose petal
Definition
Herpesviridae
Term
Donovan bodies
Definition
Klebsiella granulomatis
Term
Frothy, yellowish-green discharge
Definition
Trichomoniasis
Term
Germ tubes
Definition
Candida dubliniensis
Term
Hutchinson teeth (notched incisors)
Definition
Congenital syphilis (treponema pallidum)
Term
Growth on chocolate, not on blood
Definition
Neisseria gonorrheae
Term
Kidney-bean shaped diplococci
Definition
Neisseria gonorrheae
Term
Koilocyte
Definition
Papovaviruses
Term
Many PMNs, no organisms on Gram stain
Definition
Chlamydia trachomatis
Term
Mulberry molars
Definition
Congenital syphilis (treponema pallidum)
Term
Saber shins
Definition
Congenital syphilis (treponema pallidum)
Term
Saddle nose
Definition
Congenital syphilis (treponema pallidum)
Term
School of fish
Definition
Hemophilus ducrey
Term
Snuffles
Definition
Congenital syphilis (treponema pallidum)
Term
Strawberry cervix
Definition
Trichomoniasis
Term
Thin, gray adherent discharge
Definition
Bacterial vaginosis
Term
Tzank smear
Definition
Herpesviridae
Term
Whiff test
Definition
Bacterial vaginosis or trichomoniasis
Term
Adenovirus, type of vaccine
Definition
Live attenuated
Term
Bacillus anthracis, type of vaccine
Definition
Killed
Term
Bordetella pertussis, type of vaccine
Definition
Killed, acellular
Term
Clostridium tetani, type of vaccine
Definition
Toxoid
Term
Corynebacterium diphtheriae, type of vaccine
Definition
Toxoid
Term
Haemophilus influenzae, type of vaccine
Definition
Conjugated
Term
Hepatitis A virus, type of vaccine
Definition
Killed
Term
Hepatitis B virus, type of vaccine
Definition
Recombinant
Term
Human Papilloma virus, type of vaccine
Definition
Recombinant (6,11,16,18)
Term
Influenza virus, type of vaccine
Definition
Killed
Term
Measles virus, type of vaccine
Definition
Live, attenuated
Term
Mumps virus, type of vaccine
Definition
Live, attenuated
Term
Mycobacterium tuberculosis, type of vaccine
Definition
Live, attenuated
Term
Neisseria meningitidis, type of vaccine
Definition
Conjugated and polysaccharide but mostly conjugated
Term
Poliovirus, type of vaccine
Definition
Sabin – live, attenuated, Salk – killed
Term
Rabies virus, type of vaccine
Definition
Killed
Term
Rotavirus, type of vaccine
Definition
Live, attenuated
Term
Rubella virus, type of vaccine
Definition
Live, attenuated
Term
Smallpox, type of vaccine
Definition
Live, attenuated
Term
Streptococcus pneumoniae, type of vaccine
Definition
Polysaccharide vaccine with no conjugated protein (capsule)
Term
Varicella Zoster virus, type of vaccine
Definition
Live, attenuated
Term
Yellow fever virus, type of vaccine
Definition
Live, attenuated
Term
Japanese encephalitis virus, type of vaccine
Definition
Inactivated
Term
Rickettsia prowazekii, type of vaccine
Definition
Killed
Term
Salmonella typhi, type of vaccine
Definition
Typhoid
Term
Tick-borne encephalitis virus, type of vaccine
Definition
Inactivated
Term
Vibrio cholera, type of vaccine
Definition
Killed, inactivated whole cell
Term
Yersinia pestis, type of vaccine
Definition
Live
Term
Bacillary angiomatosis
Definition
Bartonella Hensalae
Term
Bipolar staining Gram-negative rod
Definition
Pasturella Multocida
Term
Broad-based budding yeast
Definition
Blastomyces
Term
Bull’s-eye rash
Definition
Borrelia Burgdophia
Term
Butterfly facial rash
Definition
Erysipelas
Term
Copper-colored rash
Definition
Syphilis
Term
Dewdrops on a rose petal
Definition
Herpes Simplex
Term
Fifth disease
Definition
Parvovirus B19
Term
Fish tank granuloma
Definition
Mycobacterium marinum
Term
Flesh-eating bacteria
Definition
Step Pyogenes or Staph Aureus
Term
Honey-crusted lesions
Definition
Staph Aureus or Step Pyogenes
Term
Hot tub folliculitis
Definition
Pseudomonas
Term
Koplik spots
Definition
Measles = Paramyxovirus Infection
Term
Lacy body rash
Definition
HHV-6
Term
Papular/pustular rash with different stages
Definition
Chickenpox - VZV
Term
Pustular rash all in same stage
Definition
Smallpox – variola major and minor
Term
Rash on hands/feet spreads to trunk
Definition
Rickettsia Rickettsiae
Term
Rash starts behind ears, spreads down body
Definition
German Measles = Toga virus
Term
Romaña sign
Definition
Chagas…this is the Chigoma on the face
Term
Rose gardener disease
Definition
Sporothryix
Term
Sandpaper rash
Definition
Scarlet Fever = Strep Progenes
Term
Slapped cheek fever
Definition
B19 Parvovirus
Term
Spaghetti and meatballs
Definition
Pityriasis versicolor, Malassezia furfur = asexual form
Term
Tzank smear
Definition
Herpes Infection
Term
Wool-sorter disease
Definition
Bacillus Antracis = Anthrax
Term
B cell lymphoma
Definition
EBV
Term
Blackwater fever
Definition
P. falciparum
Term
Bladder Cancer
Definition
Schistosomes
Term
Burkitt lymphoma
Definition
EBV
Term
Cervical cancer
Definition
HPV
Term
Colon cancer
Definition
Streptococcus bovis
Term
Floppy baby syndrome
Definition
C. botulinum
Term
Gastric adenocarcinoma
Definition
H. pylori
Term
Gastric MALT B-cell lymphomas
Definition
H. pylori
Term
Guillain-Barré syndrome
Definition
Campylobacter jejuni
Term
Hairy oral leukoplakia
Definition
EBV
Term
Hemolytic uremic syndrome
Definition
E. coli O157
Term
Hyperinfection syndrome
Definition
Strongyloides stercoralis
Term
Kaposi sarcoma
Definition
HIV
Term
Katayama syndrome
Definition
Schistosomes
Term
Malabsorption syndrome
Definition
G. lamblia
Term
Nasopharyngeal carcinoma
Definition
EBV
Term
Primary hepatocellular carcinoma
Definition
Hepatitis C and B
Term
Reactive arthritis
Definition
Chlamydia, C. jejuni, salmonella, shigella, yersinia
Term
Reiter syndrome
Definition
Chlamydia
Term
Waterhouse-Friedrichsen syndrome
Definition
N. meningitidis
Term
Weil disease
Definition
Leptospirosis
Term
X-linked lymphoproliferative disease
Definition
EBV
Term
Bile esculin agar
Definition
Group D streptococci
Term
Blood agar: a-hemolytic
Definition
Strep. Pneumo, strep viridans
Term
Blood agar: b-hemolytic
Definition
Strep. Pyogenes
Term
Blood agar: g-hemolytic
Definition
Group D strep
Term
Blood agar: CAMP positive
Definition
Group B strep or listeria
Term
Bordet-Gengou agar
Definition
Bordetella pertussis
Term
Buffered charcoal yeast extract agar
Definition
Legionella
Term
Chocolate agar
Definition
Haemophilus and Neisseria
Term
Lowenstein-Jensen agar
Definition
M. tuberculosis
Term
MacConkey agar
Definition
Gram – bacteria that ferment lactose
Term
Regan-Lowe media
Definition
Bordetella pertussis
Term
Sabouraud dextrose agar
Definition
Fungi
Term
Sorbitol MacConkey agar
Definition
E. coli O157
Term
Thayer-Martin agar
Definition
Neisseria spp.
Term
Thiosulfate citrate bile salts sucrose agar
Definition
Vibrio spp.
Term
Eaton medium
Definition
Mycoplasma pneumoniae
Term
Egg yolk agar
Definition
Clostridium
Term
Eosin Methylene Blue (EMB) agar
Definition
Gram (-) enteric bacilli
Term
Hektoen enteric agar
Definition
Shigella and salmonella
Term
Loeffler media
Definition
Diphtheria bacilli
Term
Mannitol salt agar
Definition
Staphylococci
Term
Tellurite media
Definition
Diphtheria bacilli
Term
Thioglycolate broth
Definition
Determines level of O2 requirement
Term
Triple Sugar Iron (TSI) agar
Definition
Differentiate enterics based on reducing sulfur and fermenting carbohydrates
Term
Xylose-Lysine-Deoxycholate (XLD) agar
Definition
Salmonella and shigella
Term
Warthin Starry stain
Definition
Bartonella Hensalae
Term
CD3
Definition
T cell
Term
CD5
Definition
T cell, B cell, Expressed in: Acute lymphoblastic leukemia, cutaneous T cell lymphoma, Expressed on CLL
Term
CD8
Definition
CTL, Uses: Quantify cytotoxic T cells (Tc), Def in: Familial CD8 deficiency;
Term
CD14
Definition
Macrophase, TLR for LPS
Term
CD19
Definition
Pre B cells, mature B cells, follicular DC, Signal transducer on B cells. Expressed on CLL
Term
CD20
Definition
Pre B Cells, Mature B cells, Chain of the CR2 co-receptor. Expressed on CLL
Term
CD21
Definition
B cell (EBV receptor) ; , Follicular DC, Receptor for complement component C3d; part of Bcell coreceptor w/ CD19
Term
CD28
Definition
T cells; Co-receptor on T cells that binds B7
Term
CD34
Definition
Hematopoietic stem cells
Term
CD40L (CD154)
Definition
T cells. Def in Hyper IgM syndrome
Term
CD56
Definition
NK cells
Term
CD61
Definition
Platelets (glycoprotein IIIa)
Term
CD86 (B7.2)
Definition
Cell distribution: B cells, monocytes. Function: Regulates T cell activation. Clinical use/notes: Ligand for CD 28 and CD152
Term
CD80 (B7.1)
Definition
Subset of B cells. Function: Regulates T cell activation. Clinical use/notes: Ligand for CD28 and CD152
Term
CD40
Definition
B cells, macrophages, dendritic cells. Function: Promotes isotype switching. Clinical use/notes: Binds CD 154; co-receptor on B cells
Term
CD16
Definition
NK cells, macrophages, PMN, Function: FcγR; phagocytosis; ADCC, Uses: Quantify NK cells
Term
CD4
Definition
T helper cells, Function: Co-receptor for MHC II, Uses: Quantify Th cells, receptor for HIV
Term
Virulence factor and MOA for: Acute glomerulonephritis (GABHS- M12 strains)
Definition
Virulence factor: M protein, MOA: Disruption of complement binding to immune complex (disrupts c3b)à decreases removal of complex
Term
Virulence factor and MOA for: Botulism
Definition
Botulinum toxins: Affect peripheral cholinergic synapses by blocking the NMJ and inhibiting the release of NT (AcH) àprevents contraction/flaccid paralysis
Term
Virulence factor and MOA for: Cholera
Definition
Cholera toxin (heat labile): Permanently activates Gs --> increases cAMP
Term
Virulence factor and MOA for: Diphtheria
Definition
Diphtheria toxin (heat labile): Inactivates EFàInhibits eukaryotic protein synthesis
Term
Virulence factor and MOA for: Escherichia coli meningitis
Definition
K1 (capsular) antigen; Antiphagocytic
Term
Virulence factor and MOA for: Escherichia coli UTI
Definition
Pili: Adherence to urethral mucosa
Term
Virulence factor and MOA for: Gas gangrene
Definition
Alpha-toxin (lecithinase ): Breaks down lipids in cell membranes --> cell death
Term
Virulence factor and MOA for: Gonorrhea
Definition
Pili (antigenic): Enhance attachment to host epithelium and mucosal surfaces. Antigen shuffling allow variation of pili over time
Term
Virulence factor and MOA for: Gram-negative septic shock
Definition
LPS; Increased immune response --> cytokine storm
Term
Virulence factor and MOA for: Klebsiella pneumoniae
Definition
Capsule: antiphagocytic
Term
Virulence factor and MOA for: Pneumococcal pneumonia/meningitis
Definition
Capsule: Antiphagocytic
Term
Virulence factor and MOA for: Peptic ulcers (H. Pylori)
Definition
Urease: Cleaves urea à Produces ammonia ions (NH3) that neutralize stomach acid in the vicinity of the organism. MOA: Cleaves urea à Produces ammonia ions (NH3) that neutralize stomach acid in the vicinity of the organism
Term
Virulence factor and MOA for: Pseudomonal pneumonia
Definition
Capsule: Antiphagocytic
Term
Virulence factor and MOA for: Pseudomonal wound infection
Definition
Pseudimonal toxin: Similar to diphtheria toxin (interferes with EF2)
Term
Virulence factor and MOA for: Rheumatic fever (GABHS)
Definition
M protein: Body makes Ab against strep but they happen to cross react and bind to the heart tissue
Term
Virulence factor and MOA for: Scalded skin syndrome
Definition
Exfoliative toxin (ET): Superantigen that attacks the intercellular adhesive of the stratum granulosumàmarked epithelial desquamation
Term
Virulence factor and MOA for: Scarlet fever
Definition
Erythrogenic toxin (acquired this toxin by lysogeny – bacterial phage (virus that infects bacteria)). Responsible for fever and rash
Term
Virulence factor and MOA for: Staphylococcal food poisoning (aur)
Definition
enterotoxin; Induces cAMP
Term
Virulence factor and MOA for: Strep throat
Definition
M protein; antiphagocytic
Term
Virulence factor and MOA for: Tetanus
Definition
Virulence factor: Tetanus toxin (tetanospasmin). MOA of toxin: Very potent. Stops release of NT GABA, glycine and excitatory NTàdangerous overactivity in mm from smallest stimuli
Term
Toxic shock syndrome (S. Aureus)
Definition
Virulence factor: Superantigen exotoxin. MOA of Toxin has affinity for the T cell receptor/MHC Class 2 antigen complex à stimulates an enhanced T lymphocyte responseàT cell activation causes large amount of T cell cytokine release à TSS
Term
Virulence factor and MOA for: Whooping cough (B. Pertussis)
Definition
Virulence factor: Pertussis Toxin (PT). MOA Catalyzes the ADP ribosylation of the alpha-I subunit of the G protein à inactivates Gi à increases cAMP
Term
Virulence factor and MOA for: Meningococcal meningitis
Definition
1. polysaccharide capsule (only in N. Meningitis NOT GC): antiphagocytic. 13 serogroups (A,B,C,Y, W135 most common). We don’t have a vaccine for B so you can get meningitis even with the vaccine. 2. LOS- lipooligosaccharide (no O antigen) - endotoxin: causes immune response (cytokine storm). 3. Pili: Attachment to nasopharyngeal mucosa
Term
Virulence factor and MOA for: Tuberculosis
Definition
Facultative intracellular Virulence dependent on ability to survive and grow in host cells. Makes no toxins but when engulfed by macrophages, bacterial sulfolipids inhibit the fusion of phagocytic vesicles with lysosomes. MOA Inhibits fusion of phagosome/lysosome.
Term
Virulence factor and MOA for: Traveler’s diarrhea (ETEC)
Definition
Enterotoxins: 1. Heat stabile toxin (ST) --> causes increase in cellular cGMP. 2. Heat labile toxin (LT)- essentially identical to cholera toxin which --> causes increase in cellular cAMP MOA: Prolonged hypersecretion of chloride ions and water by the intestinal mucosal cells and inhibits the reabsorption of Naàhyperosmotic diarrhea
Term
Virulence factor and MOA for: Shigellosis
Definition
1. Shiga toxin: inhibit protein synthesis by interfering with 60s (like EHEC). 2. Invasion of intestinal mucosa via actin polymerization --. Propel themselves
Term
Virulence factor and MOA for: Pseudomembranous colitis
Definition
2 toxic polypeptides: 1. enterotoxin A: damages mucosa. 2. Cytotoxin B: kills the cells
Term
Virulence factor and MOA for: Meningococcal septic shock , (N. Meningitis)
Definition
LOS: Increased immune response --> cytokine storm
Term
Virulence factor and MOA for: Listeriosis
Definition
1. Facultative intracellular: Escapes phagosome before lysosome/phagosome fusion. 2. Listeriolysin O hemolysin: Lyses phagocytic vacuoles/damages membranes
Term
Virulence factor and MOA for: Anthrax (B. Anthracis)
Definition
Virulence factors are: 1. Anthrax Toxin has both (A) – LF --- lethal factor and -- EF — edema factor as well as (B) - PA – protective Ag 2. Glutamic acid Capsule MOA of Virulence factor 1: anthrax toxin – increases intracellular cAMP --> severe edema (widened mediastinum, etc. ). MOA of virulence factor 2: antiphagocytic
Term
Virulence factor and MOA for: Hemolytic uremic syndrome (0157:H7)- EHEC
Definition
Shiga-like toxin (Verotoxin ): Inhibits protein synthesis by interfering with 60s ribosomes (like Shigella toxin)
Term
Virulence factor and MOA for: Bacillus cereus food poisoning
Definition
Virulence factors: 1. Emetic Heat Stabile enterotoxin and 2. Diarrheal Enterotoxin (heat labile). MOA for VF's: 1. causes nausea, vomiting, abdominal cramps, 2. increases cAMP
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