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Micro 12/05/12 Introduction to Virology
HDPP final at UMMSM
14
Microbiology
Graduate
12/09/2012

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Cards

Term
What are viruses?
Definition
Subcellular infectious agents that replicate only inside living host cells and are therefore obligate intracellular parasites
Term
What nucleic acids do viruses contain?
Definition
DNA or RNA but not both
Term
How do viruses reproduce?
Definition
Synthesis of subunits they assembly of complete virus
Term
What are consequences of viruses being non-living?
Definition
They must be able to utilize host cell processes to produce their components and must encode and required processes not provided by the cell.
Term
What is a "naked virus"?
Definition
A virus with only the nucleic acid and the capsid, no envelope.
Term
What is reverse transcription?
Definition
The process of converting RNA to DNA
Term
What enzyme is important for viruses to make on their own because it is not found in normal cells?
Definition
RNA-dependent RNA polymerase
Term
What are defective viruses?
Definition
Viruses without a complete genome, so they are only able to replicate/form a protein coat when their defect is complemented by a helper virus
Term
What is a permissive cell?
Definition
A cell that provides the biosynthetic machinery to support the complete replicative cycle of the virus
Term
How is the capsid synthesized?
Definition
Proteins assemble in protomers, protomers assemble in pentamers (capsomers), which assemble into the capsid/nucleocapsid
Term
Where do most DNA viruses replicate? RNA?
Definition
DNA: nucleus
RNA: cytoplasm
Term
What are some properties of naked capsids?
Definition
Environmental stability to temperature, acid, proteases, detergents, and drying; release from cell by lysis
Term
What are some properties of enveloped virused?
Definition
Environmentally labile and disrupted by acid, detergent, drying, and heat; modify the cell membrane during replication; released by budding and cell lysis
Term
What are viroids and prions?
Definition
Both are subviral pathogens. Viroids contain only RNA, and prions contain only protein
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