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Metabolism Intro
Medical School Biochemistry
32
Biochemistry
Graduate
09/28/2011

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Cards

Term
What is the rate limiting step in metabolic pathways?
Definition
irreversible reactions
Term
What is the name of the initial substance before it goes through the metabolic pathway?
Definition
Pathway Substrate
Term
What is the name of the final substance after going through the metabolic pathway?
Definition
Pathway end-product
Term
What is the name for the products formed during the metabolic pathway between metabolic steps?
Definition
Enzyme intermediates
Term
What type of enzymes catalyze reversible reactions in the metabolic pathway?
Definition
Michaelis-Menten enzymes
Term
What type of enzymes catalyze rate-limiting irreversible reactions along the metabolic pathway?
Definition
Allosterically regulated enzymes
Term
Metabolic pathways ending in "olysis" are what kind of pathway?
Definition
Catabolic
Term
Metabolic pathways ending with "genesis" are what kind of pathways?
Definition
Anabolic
Term
Enzymes that follow Michaelis-Menten kinetics have what type of curve?
Definition
Hyperbolic
Term
What type of curve is exhibited by Allosteric enzymes?
Definition
Sigmoid
Term
What are the properties of Catabolic Pathways?
Definition
Degradative
Oxidative (e- removed)
energy-generating
converging (common intermediates)
Term
What are the properties of Anabolic pathways?
Definition
biosynthetic
reductive (e- added)
energy-consuming
diverging
Term
What are the carbohydrate fuels in the body?
Definition
Glucuse (Dextrose)
lactate
Term
What is the protein fuel of the body?
Definition
Amino Acids
Term
What are the fat fuels of the body?
Definition
Fatty acids and Ketone bodies (acetoacetate and Beta hydroxybutyrate)
Term
What is the major fatty acid fuel source?
Definition
palmitate
Term
How is palmitate transported in the body?
Definition
Since palmitate is water insoluble, it is transported on albumin
Term
What are the end products of aerobic degradation of fuel molecules?
Definition
CO2 and ATP
Term
What are the requirements for Aerobic degradation?
Definition
Fuel molecules, mitochondria, O2
Term
What is the caloric value of for Carbohydrates?
Definition
4 kcal/gm
Term
What is the caloric value for protein?
Definition
4 kcal/gm
Term
What is the caloric value for fat?
Definition
9 kcal/gm
Term
What is the caloric value for Alcohol?
Definition
7 kcal/gm
Term
What enzymes remove electrons as hydrogen pairs in metabolic pathways?
Definition
Dehydrogenases
Term
What type of hydrogen does Nicotinamide Adenine Dinucleotide (NAD) accept?
Definition
Hydride Ion (H-) to form NADH
Term
What type of hydrogen does Flavin Adenine Dinucleotide (FAD) accept?
Definition
H2 to form FADH2
Term
What is the name for and clinical presentation of Niacin Deficieny?
Definition
Pellagra. Presents with dermatitis, diarrhea, and dementia
Term
What is the clinical presentation of Riboflavin deficiency?
Definition
Glossitis (purplish hue to tongue), Cheilosis (chapped lips), butterfly rash
Term
What are the functional groups derived from B complex necessary for production of NAD?
Definition
Nicotinic Acid (Niacin) or Nicotinamide (niacinamide)
Term
What is vitamin B2? Why is it important?
Definition
B2 is Riboflavin, it is a necessary vitamin for the creation of FAD
Term
What are the substrates and products of oxidative phosphorylation?
Definition
NADH or FADH2 -> NAD or FAD

O2 -> H2O

ADP + Pi -> ATP
Term
What is the most common coenzyme used by dehydrogenase?
Definition
NAD
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