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metabolism diabetes
Tufts D17 Exam IV
29
Biochemistry
Professional
11/12/2013

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Cards

Term
What is the first source of glucose once dietary glucose is used up
Definition
glycogen
Term
After 16 hours what is the main source of glucose?
Definition
gluconeogenesis
Term
How much body protein do you burn a day when starving?
Definition
6%
Term
As one starts to fast what is the first source of glycogen?
Definition
liver
Term
In late starvation how much protein do you use a day?
Definition
20 g/day
Term
In late starvation do levels of nitrogen excretion increase or decrease?
Definition
decrease
Term
Ammonia stays high why?
Definition
PH control. And preserves potassium
Term
Why can't u feed a starving person
Definition
They sequester body phosphate so they need to begin to eat slowly
Term
The CDC says what percent of diabetic patients ar getting proper treatment?
Definition
7%
Term
Oral manifestation of diabetes
Definition
Inc. caries rate. Infection.xerostomia. impaired healing. Enamel hypoplasia.inflammation candidates. Abnormal eruption
Term
What are the long term complications of diabetes
Definition
Diabetic eye, feet, kidney, heart.
Term
How many diabetics haze type 1
Definition
5-10%
Term
Diabetic ketoacidosis
Definition
Comatose, fruity breath, treat them with insulin.
Term
Type II diabetes is associated with obesity and what age group?
Definition
40+. Recently on the rise in teenagers
Term
Plasma insulin is higher than normal
Definition
Because tissues don't respond to insulin as well.
Term
Ketoacidosis hypoglycemia and low insulin are associat4d with which type?
Definition
Type I
Term
How do you treat type II?
Definition
Diet, insulin, and oral antibiotic
Term
What is used to measure insulin secretion?
Definition
C peptide
Term
Insulin decreases what 4 things
Definition
Blood glucose, glycogen synthetase activity, gluconeogenic reactions, hormone sensitive lipase (lipid deposition)
Term
Insulin increases what 5 things
Definition
Glycolysis in liver, fatty acid synthesis in liver, lipoprotein lipase, TAG synthesis, protein synthesis
Term
What controls insulin production?
Definition
GLP1 and GIP. Causes ingested insulin to work better than eating insuling
Term
If you inhibit a calcium channel what happens to insulin secretion?
Definition
It goes down
Term
What protease inhibitor prolongs GLP1/GIP half life
Definition
DPPIV
Term
3 problems with hyperglycemia
Definition
Glucose reacts with metal generating reactive oxygen species. 2. polyol pathway generates sorbitol and affects NADPH/NadP+ ratio. 3. Gyration generates protein addicts leading to advanced gyration end productsthat are reactive
Term
Why do diabetes have poor glucose control?
Definition
Insulin promotes glucose uptake, favors glycogen formation, and inhibits gluconeogenesis.
Term
What drug blocks gluconeogensis
Definition
methformin. 60 million prescriptions last year. Possibly used against cancer
Term
What are incretins?
Definition
GLP GIP
Term
Loss of insulin does what to lipid profile?
Definition
Lowers HDL and raises LDL, and increases TG.
Term
Which type shows diabetic ketoacidosis?
Definition
TYPE I. results in heavy breathing which is the bodies attempt to balance the pH.
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