| Term 
 | Definition 
 
        | DAY 1 the day menses first appears
 
 DAY 1-4 (length varies per person)
 menstruation
 
 "FERTILE WINDOW"
 days 10-17 (unpredictable)
 in the middle of the menstrual cycle
 
 [image]
 
 during the menstrual cycle (0-5) there is a low level of estrogen and progesterone and FSH and LH are low
 
 the endometrium thickens and becomes a favorable environment for implantation
 
 ovulation occurs; LH and FSH surge occurs at ovulation
 
 after fertilization, the ovum is ready to implant on the endometrium
 
 for the endometrium to be favorable it has to be thick
 
 at the end of the cycle, when the hormones decrease then the endometrium is sloughed
 
 to suppress the LH and FSH surge, it would prevent ovulation from occurring
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | contraception:  prevention of pregnancy following sexual intercourse by 1) inhibiting viable sperm from coming into contact with a mature ovum (barriers or prevent ovulation)
 2) preventing a fertilized ovum from implanting successfully in the endometrium (create an unfavorable uterine environment)
 
 goal: planned and desired pregnancies
 |  | 
        |  | 
        
        | Term 
 
        | benefits of contraception |  | Definition 
 
        | control the rapid population growth that has begun to threaten human survival 
 essential to a woman's ability to achieve her individual goals and to contribute to her sense of well being
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | effectiveness safety
 accessibility
 acceptability
 complexity
 spontaneity
 cost
 |  | 
        |  | 
        
        | Term 
 
        | natural contraception methods |  | Definition 
 
        | lactational infertility (amenorrhea) 
 infant receives only breast milk and mother does not have menses
 
 baby suckling on mother's nipples causes surge in maternal prolactin, which inhibits estrogen production and ovulation
 
 may last up to 6 months
 
 HIGH FAILURE RATE
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | TYPICAL USE FAILURE = USER FAILURE failure that occurs secondary to person using methods, following directions correctly and consistently
 ex)  taking the medication and vomiting; taking the medication while taking antibiotics
 
 PERFECT USE FAILURE = METHOD/PRODUCT FAILURE
 failure that subject has no control over, does not depend on the proper use of contraceptive alone
 |  | 
        |  | 
        
        | Term 
 
        | mechanism of action for hormonal contraceptives |  | Definition 
 
        | ESTROGEN 
 suppress FSH, preventing development of a dominant follicle
 suppress LH
 stabilize endometrial lining:  bleeding control
 potentiates progestin's action
 induction of luteolysis (degradation of corpus luteum, not allowing implantation)
 accelerated ovum transport
 
 PROGESTIN
 
 suppress FSH and LH surge, inhibiting ovulation
 thickens cervical mucus
 atrophies (thins) endometrium:  inhibition of implantation
 inability of capacitation:  inhibits activation of spermatic enzymes needed for penetration into ovum
 slows ovum transport
 
 just progesterone will not give the optimal suppression of FSH and LH
 |  | 
        |  | 
        
        | Term 
 
        | hormonal contraception examples |  | Definition 
 
        | oral:  combination (estrogen and progestin) - COCs; progestin only - POPs 
 vaginal ring
 
 transdermal patch
 
 injectable
 
 intrauterine devices (IUD)
 |  | 
        |  | 
        
        | Term 
 
        | most common estrogens in oral contraceptions |  | Definition 
 
        | 1980s FDA states no OCs are to have > 50 mcg of estrogen; the higher the amount of estrogen, the more at risk of complications and ADRs 
 mestranol (ME):  present in older pills, liver biotransforms mestranol to ethinyl estradiol
 
 ethinyl estradiol (EE):  most commonly used
 |  | 
        |  | 
        
        | Term 
 
        | most common progestins used in oral contraception |  | Definition 
 
        | progestins can have progestin activity, estrogenic activity, and androgenic activity 
 androgenic activity may cause male-like characteristics:  hair growth (hirsutism), oily skin, increased sex drive
 
 if someone is complaining of low sex drive, consider switching to a higher androgenic activity progestin
 
 if someone is complaining of oily skin and hair growth then want to switch them to a progestin with less androgenic activity
 
 levonorgestrol is the most common progestin used
 |  | 
        |  | 
        
        | Term 
 
        | progestins with high androgenic activity |  | Definition 
 
        | norgestrel (levonorgestrel is the active isomer of norgestrel) norethindrone
 ethynodiol
 |  | 
        |  | 
        
        | Term 
 
        | progestins with low androgenic activity |  | Definition 
 
        | desogestrel norgestimate
 drospirenone has anti-androgenic effects
 |  | 
        |  | 
        
        | Term 
 
        | combination products - 21 day regimens vs. 28 day regimens |  | Definition 
 
        | 21 day regimen: take the pills for 21 days and on days 22-28 don't take anything or continue taking the pills
 
 28 day regimen:  active pills for 21 days and on days 22-28 they take placebo pills (to help remember to take the pills every day)
 |  | 
        |  | 
        
        | Term 
 
        | monophasic vs. multiphasic |  | Definition 
 
        | monophasic: same amount of estrogen and progestin in all of the pills
 
 multiphasic:
 to prevent break through bleeding
 OCs are supposed to mimic the menstrual cycle, normally the levels fluctuate throughout the cycle
 
 biphasic:  start at a low dose of estrogen and titrate to a higher dose of estrogen
 
 triphasic:  3 levels of estrogen
 
 multiphasic OCs usually contain the same level of progesterone in each tablet
 
 less break through bleeding with muliphasic OCs; shorter menses
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 21 day regimen 
 monophasic
 
 you can take the week off, but it is recommended to continue to take the pills (do not take a break)
 
 less suppression of LH and FSH; only a 3 hour window to take the pill
 
 combination products:  should take around the same time each day, but doesn't matter as much as with the POPs
 
 less effective than COCs with typical use
 
 irregular and unpredictable menstrual bleeding
 
 may not inhibit ovulation completely
 
 risk of ectopic pregnancy
 |  | 
        |  | 
        
        | Term 
 
        | selecting an OC for your patient:  initial choice for a young, healthy female with no pre-existing conditions |  | Definition 
 
        | low-dose combination oral contraceptive 
 30-35 mcg ethinyl estradiol
 
 metabolically neutral progestin (doesn't have high androgenic activity)
 
 multiphasic
 |  | 
        |  | 
        
        | Term 
 
        | first day or Sunday start or quick start |  | Definition 
 
        | first day: use hormonal contraceptive during the first 24 hours of menstrual cycle
 
 Sunday start:
 1st Sunday after start of menstrual cycle
 MUST USE BACK UP FOR 1ST 7 DAYS
 
 quick start (any day):
 MUST USE BACK UP FOR 1ST 7 DAYS
 |  | 
        |  | 
        
        | Term 
 
        | patient instructions:  combination oral contraceptive |  | Definition 
 
        | begin on day 1 or Sunday after start of menstrual cycle 
 take one pill daily for 21 days; then may take placebo pills (28 day pills) or stop for 7 days
 
 NOTE:  important to take pill ~ the same time each day esp. with decreased hormone content
 |  | 
        |  | 
        
        | Term 
 
        | patient instructions:  progestin only |  | Definition 
 
        | begin on day 1 of menstrual cycle no other options with progestin only except to begin on day 1 of the menstrual cycle
 
 take one pill every day continuously at the same time
 ONLY HAVE A 3 HOUR WINDOW WITH PROGESTIN ONLY!
 
 use another birth control method for next 48 hours if more than 27 hours between pills or miss 1 pill
 
 NOTE:  important to take pill ~ the same time each day (+/- 3 hours)
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | nausea, vomiting headaches
 dizziness
 spotting and bleeding
 mood changes including depression
 possible weight gain
 
 side effects worse in the 1st 3 months:
 nausea/dizziness
 cyclic weight gain, edema
 breast fullness, tenderness
 BTB
 contact lenses fail to fit:  due to estrogens making the eyes swollen; fixed by decreasing estrogen component
 abdominal cramping
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | spotting breakthrough bleeding:  do not have the stabilization of the endometrium from estrogens
 amenorrhea
 mood changes
 headaches
 hot flashes
 |  | 
        |  | 
        
        | Term 
 
        | COC side effects requiring an adjustment:  symptoms of ESTROGEN EXCESS |  | Definition 
 
        | nausea bloating
 hypermenorrhea
 hyperpigmentation
 hypertension
 migraine headache
 leg cramps
 cervical mucorrhea
 |  | 
        |  | 
        
        | Term 
 
        | COC side effects requiring an adjustment:  symptoms of ESTROGEN DEFICIENCY |  | Definition 
 
        | irritability early and/or midcycle breakthrough bleeding
 nervousness
 |  | 
        |  | 
        
        | Term 
 
        | COC side effects requiring an adjustment:  symptoms of PROGESTIN EXCESS |  | Definition 
 
        | increased appetite weight gain
 hypomenorrhea
 oily skin and hair
 acne
 hair loss or hirsutism (if androgenic)
 depression
 |  | 
        |  | 
        
        | Term 
 
        | COC side effects requiring an adjustment:  symptoms of PROGESTIN DEFICIENCY |  | Definition 
 
        | late breakthrough bleeding weight loss
 hypermenorrhea
 amenorrhea
 |  | 
        |  | 
        
        | Term 
 
        | postpartum use of birth control in non-breastfeeding women |  | Definition 
 
        | Category 1:  > 42 days 
 Category 2:  21-42 days without risk factors
 
 Category 3:  21-42 days with risk factors for VTE (> 35y, previous VTE, thrombophilia, immobility, postcesarean delivery, smoking, transfusion at delivery, BMI > 30, postpartum hemorrhage)
 
 Category 4:  < 21 days
 
 WITH RISK FACTORS:  START AT 42 DAYS
 WITHOUT RISK FACTORS:  START AT 21 DAYS
 |  | 
        |  | 
        
        | Term 
 
        | postpartum use of birth control in breastfeeding women |  | Definition 
 
        | Category 2:  > 42 days; 30-42 days without risk factors 
 Category 3:  30-42 days with risk factors; 21-30 days with or without risk factors
 
 Category 4:  < 21 days
 
 COC IN BREAST FEEDING WOMEN CAN BE STARTED (WITHOUT ANY RISK FACTORS OR WITH RISK FACTORS) AT 42 DAYS
 |  | 
        |  | 
        
        | Term 
 
        | postpartum, lactating:  use of progestin only OC |  | Definition 
 
        | should not be initiated < 1 month postpartum 
 decreased natural anticoagulants, hypercoaguable state
 
 low dose COCs can be used:  concerns of decreased milk production
 
 pelvic rest recommened for 4 weeks (vaginal delivery) or 6 weeks (Caesarean)
 |  | 
        |  | 
        
        | Term 
 
        | COC CONTRAINTICATIONS (WHO CATEGORY 4) |  | Definition 
 
        | DVT/PE or history of 
 CVD, CAD
 
 complicated DM:  nephropathy, retinopathy, neuropathy, diabetes for more than 20 years
 
 breast cancer or strong family history
 
 pregnancy
 
 lactation (<6 weeks postpartum)
 
 gallbladder disease:  the estrogen component can cause gallstones, can worsen gallbladder disease
 
 hypertension:  > 160/100; get blood pressure under control first
 
 liver abnormalities:  metabolized in the liver
 HA or migraines with neurologic symptoms:  rare cases of retino-thrombosis associated with COC; if you have migraines with neurologic symptoms you are at increased risk of retino-thrombosis; neurologic symptoms = seizures
 
 major surgery:  hypercoaguable state
 
 >25 yo + smoker:  nicotine and age and estrogen puts them at risk for clots; DO NOT USE A PRODUCT WITH ESTROGEN IN IT
 
 undiagnosed abnormal bleeding
 |  | 
        |  | 
        
        | Term 
 
        | complications associated with COC use |  | Definition 
 
        | myocardial infarction and ischemic stroke 
 venous thromboembolism
 
 hypertension - small increase
 
 cholelithiasis/cholecystitis - gallbladder disease
 
 visual changes
 
 symptoms of concern:
 
 ACHES - KNOW THESE!!
 
 abdominal pain (possible gallbladder disease)
 chest pain (possible MI)
 headaches which are severe (stoke)
 eye problems:  blurred or loss of vision (retinal thrombosis)
 severe leg pain (DVT)
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | date of last menstrual period 
 regularity in cycles
 
 incidence of PMS
 
 previous treatment
 
 physical exam:
 BP
 breast examination
 PAP smear
 liver evaluation
 family history
 social history
 |  | 
        |  | 
        
        | Term 
 
        | progestin only candidates |  | Definition 
 
        | smokers > 35 years of age 
 history of thromboembolic events
 
 nursing moms (low dose COC's can also be used)
 
 history of estrogen related headaches
 
 uncontrolled hypertension
 
 any estrogen related side effect
 |  | 
        |  | 
        
        | Term 
 
        | special populations:  smokers |  | Definition 
 
        | > 15 cigarettes per day and > 35 years old = NO ESTROGEN CONTAINING OCS risks exceed pregnancy risk
 
 < 15 cigarettes per day and > 35 years old = use with caution
 
 may use low dose 20 mcg estrogen formulation
 
 progestin only pills - recommended as best option
 |  | 
        |  | 
        
        | Term 
 
        | special populations:  hypertension |  | Definition 
 
        | estrogen - small increases in blood pressure 
 blood pressure restoration 3-6 months after D/C
 
 low dose estrogen OCs ok if well controlled
 
 end organ disease (CAD, CHF, CVD) = NO!!!
 
 K+ cautions
 yaz and yasmin can increase K and cause hyperkalemia b/c it contains a different type of progesterone
 |  | 
        |  | 
        
        | Term 
 
        | special populations:  diabetes |  | Definition 
 
        | no significant effects on insulin, glucose or glucagon release 
 women with diabetes AND vascular disease = NO
 |  | 
        |  | 
        
        | Term 
 
        | special populations:  dyslipidemia |  | Definition 
 
        | progestins:  decrease HDL and increase LHL 
 estrogens:  increase removal of LHL from circulation and increase HDL
 
 estrogens alter VLHL composition and increase triglycerides
 
 uncontrolled (LHL > 160, HDL < 35, TGs > 250) + additional risk factors = USE ALTERNATIVE METHOD
 |  | 
        |  | 
        
        | Term 
 
        | special populations:  systemic lupus erythematosus |  | Definition 
 
        | risk associated with pregnancy is high 
 association between VTE and OCO use in women with:
 systemic lupus erythematosus
 history of vascular disease
 antiphospholipid antibodies
 
 POPs should be used
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | hepatic induction (enzyme inducers): st. john's wort, RIFAMPIN, GRISEOFULVIN, anticonvulsants, sedative/hypnotics
 decreased effectiveness of the oral contraceptives
 use a back up for the ENTIRE PACK
 
 decreased enterohepatic recirculation:
 broad spectrum antibiotics kill the friendly "bacteria"
 use a back up method while on the antibiotic AND 7 days after the completion of the antibiotic!
 
 anticoagulant interaction:
 increases clotting factors
 INR will go down, may have to increase the warfarin dose
 |  | 
        |  | 
        
        | Term 
 
        | what to do when a pill is missed |  | Definition 
 
        | MISSED 1 DOSE: take as soon as remembered or take 2 tablets the next day
 
 MISSED 2 IN WEEK 1 OR 2:
 take 2 tablets as soon as remembered or take 2 tablets the next 2 days
 an additional method of contraception should be used for 7 days after missed dose
 
 MISSED 2 IN WEEK 3:
 continue dose of 1 tablet per day until Sunday, then discard the rest of pack, and start a new pack that same day
 OR
 current pack should be discarded and new pack should be started that same day
 an additional method of contraception should be used for 7 days after missed dose
 
 MISSED 2 (PROGESTIN ONLY):
 take one of the missed doses, discard the other, and take daily dose at usual time
 
 MISSED 3 OR MORE:
 continue dose of 1 tablet daily until Sunday, then discard the rest of pack, and start a new pack that same day
 OR
 current pack should be discarded, and a new pack should be started that same day
 an additional method of contraception should be used for 7 days after missed dose
 
 MISSED 3 OR MORE (PROGESTIN ONLY):
 current pack should be discarded
 use another form of birth control until menses appears or pregnancy is ruled out
 |  | 
        |  | 
        
        | Term 
 
        | additional indications for oral contraceptives |  | Definition 
 
        | COC/POP induced improvements in menstrual symptoms: fewer cramps/less pain
 less flow or fewer days
 more predictable menses
 elimination of ovulation pain
 
 non-contraceptive benefits of COC (other COC indications):
 
 pelvic inflammatory disease - infection of the uterus, fallopian tubes, and other reproductive organs of the female reproductive system; usually caused by STD (chlamydia, gonorrhea); causes severe cramping; COC can help with the pain of PID
 
 premenstrual dysphoric disorder (PMDD) - more severe PMS; moodiness is very severe, depression, cry uncontrollably, social isolation, suicidal ideation
 
 dysmenorrhea/menorrhagia - heavy periods, irregular periods; taking COC will decrease period flow and make periods more predictable
 
 endometriosis - lining of the endometrium is inflamed causing severe cramping; taking COC decrease the build up of the lining and decrease pain
 
 polycystic ovarian syndrome (PCOS) - multiple cysts on the ovaries, can cause severe cramping; taking COC will decrease the cramping
 
 acne vulgaris - certain products are proven to make acne better; contain LOW androgen component to decrease acne; acne is improved in many women by using estrogen-dominant, low androgen COCs; brand names include:  Ortho Tri-Cyclen, Estrostep, Yasmin, Yaz
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | ovarian: risk decreased by 50% after 5 years
 lasts for 10-20 years after pill is DC'd
 
 endometrial:
 same as ovarian
 
 breast:
 controverisal
 strong family history of gene must be considered
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Yasmin = 3 mg drosperinone/30 mcg EE 
 first COC in US to contain drosperinone
 
 drosperinone is a synthetic sprionolactone analog
 
 indicated for acne
 
 monophasic:
 3 mg drosperinone and 30 mcg EE per tablet
 21 active yellow tabs; 7 inert white tabs per cycle
 
 take at the same time each day
 
 initiate therapy on day 1 of menstrual cycle or first Sunday after start of menstrual cycle or quick start
 
 drosperinone:
 its anti-mineralocorticoid activity counteracts the aldosterone-stimulating effects of estrogens
 estrogen-induced Na and water retention is reduced -> less increase in blood pressure, less weight gain
 more favorable effects on HDL and LDL than other progestins
 potential for hyperkalemia
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | YAZ = 3 mg drosperinon/20 mcg EE 
 indicated for PMDD and acne
 
 contains drosperinone like Yasmin
 
 24/4 dosing regimen (extended):
 24 days of hormone containing tablets and 4 days of placebo
 shorter bleed time
 decreased PMS, decreased cramping
 |  | 
        |  | 
        
        | Term 
 
        | meds to avoid (or use with caution and proper monitoring) while taking Yasmin or Yaz |  | Definition 
 
        | ACE inhibitors ARBs
 K sparing diuretics
 K supplements
 aldosterone antagonists
 NSAIDs
 
 not contraindicated, but have to monitor K levels
 |  | 
        |  | 
        
        | Term 
 
        | Loestrin 24 Fe clinical pearls |  | Definition 
 
        | 24 active "white" pills 
 take for week 1, 2, 3 and 1st part of week 4
 
 4 brown pills containing iron
 
 shorter, lighter periods without blood tests (no potassium monitoring)
 |  | 
        |  | 
        
        | Term 
 
        | Femcon Fe clinical pearls |  | Definition 
 
        | 1st chewable birth control approved by FDA May 2006 
 may be chewed, followed by full glass of water OR swallowed whole
 
 21 active + 7 reminders
 
 all 7 pills contain 75 mg of ferrous fumarate
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Beyaz = drospirenone/EE/levomefolate calcium 
 28 day pack:
 drospirenone/EE/levomefolate x 24 days
 levomefolate x 4 days
 
 levomefolate is a metabolite of folic acid
 
 folic acid is to prevent neural tube defects that can occur in babies of mothers with low folic acid levels
 
 all women of child bearing age should be taking folic acid as a supplement
 |  | 
        |  | 
        
        | Term 
 
        | Seasonale clinical pearls |  | Definition 
 
        | monophasic COC: 0.15 mg levonorgestrel
 30 mcg EE
 
 91 day regimen:
 84 active pills followed by 7 inactive pills
 
 women will get a period 4 times a year
 
 Seasonale has more incidence of break through bleeding
 |  | 
        |  | 
        
        | Term 
 
        | Seasonique clinical pearls |  | Definition 
 
        | same 4 periods/year as Seasonale 
 levonorgestrel 0.15 mg and 30 mcg EE (84 days), 10 mcg EE (7 days)
 
 proposed less break through bleeding with Seasonique
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Lybrel = 90 mcg levonorgestrel/20 mcg EE 
 1st and only low dose COC taken 365 days of the year
 
 no scheduled menstrual period
 
 high incidence of breakthrough bleeding or spotting (esp. during first 3 months of use)
 |  | 
        |  | 
        
        | Term 
 
        | Ortho Evra clinical pearls |  | Definition 
 
        | weekly transdermal patch 
 apply one patch weekly for 3 weeks
 week 4 patch free
 apply same day each week
 
 apply to clean, dry skin,
 BUTTOCK
 ABDOMEN
 UPPER OUTER ARM
 UPPER TORSO (BACK)
 
 fold prior to disposal, don't flush
 
 rotate areas the patch is applied
 at the beginning of each cycle can apply to the same area again
 
 can alternate to different areas of the body
 
 extra adhesive can be removed with baby oil
 
 same CI/efficacy as OCP
 time of day patch is changed does not matter
 
 each patch will suppress ovulation up to 9 days
 if it has been no more than 9 days since the patch was changed it is okay
 if it has been more than 9 days they should put on a new patch and use back up for 7 days
 if it has been more than 7 days since they have put on a patch, put one on and use backup for 7 days
 
 new patch start day if more than a week between patches
 
 starting the patch:
 first day within 24 hours of menses
 OR
 Sunday after menses, even if not finished, need 7 day back up
 
 label warnings:
 60% higher systemic estrogen exposure; AUC greater
 higher steady state and 25% lower peak concentration (compared to 35 mcg EE OCP)
 increases risk associated with estrogen - clotting, VTE
 
 ortho evra and body weight:
 less effective in women who weight >/= 198 lbs (90 kg)
 enhanced metabolic clearance rate in women > 90 kg
 increased absorption of hormones into body fat = decreased absorption of the hormones into the circulation (longer time to reach steady state)
 ortho evra is not recommended in patients weighting > 90 kg
 |  | 
        |  | 
        
        | Term 
 
        | NuvaRing vaginal clinical pearls |  | Definition 
 
        | flexible, combined hormonal ring 
 same CI/efficacy as OCP
 
 insert ring for 21 days, 7 days ring free
 
 FIRST TIME USER:
 insert between days 1-5 of menstrual cycle
 if inserted days 2-5 need 7 day back up
 
 increased compliance
 
 may store at room temperature, avoid extreme heat for up to 4 months
 
 provides protection for up to 35 days
 if it has been more than 35 days since inserted, take it out and start a new ring; use backup for 7 days
 
 dispose in trash can
 
 cannot be out for more than 3 hours a day
 if > 3 hours during week 1 or 2 reinsert and use back up for 7 days
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | NuvaRing 10.6 +/- 2.5 
 COC oral 21.9 +/- 2.9
 
 Ortho Evra 35.8 +/- 5.5
 
 NuvaRing has the lowest AUC of estrogen; the patch as the highest estrogen AUC
 
 when someone is stopping NuvaRing to get pregnant it usually happens faster than those taking the patch
 
 KNOW WHAT HAS THE LOWEST ESTROGEN AUC
 |  | 
        |  | 
        
        | Term 
 
        | Depo-Provera IM injection clinical pearls |  | Definition 
 
        | medroxyprogesterone acetate 
 MOA:
 inhibits ovulation
 thickens cervical mucus
 thins endometrial lining
 
 dosage regimen:
 150 mg deep IM injection in upper arm or buttock every 12 weeks (2 week grace period)
 for 1st injection, give withing the 1st 5 days of cycle if not breastfeeding, if not use back up for 7 days
 
 for breastfeeding women it has to be at least 6 weeks postpartum
 
 side effects:
 unpredictable bleeding
 weight gain - 20 lbs weight gain in 3 months is average; more weight gain in women who are not obese
 decreased bone mineral density (black box warning)
 depression
 unpredictable bleeding that may never decrease
 
 effectiveness:
 depends on patient's compliance
 with good compliance can be just as effective as COC even though it only contains progesterone
 |  | 
        |  | 
        
        | Term 
 
        | discontinuing oral contraceptives/return of fertility |  | Definition 
 
        | average ovulation delay = 1-2 weeks 
 Depo-Provera can take up to 18 months (should not be used in a patient that wants to get pregnant soon)
 |  | 
        |  | 
        
        | Term 
 
        | intrauterine contraceptives |  | Definition 
 
        | "reversible sterilization" 
 immediate return of fertility after removal
 
 1) Mirena - levonorgestrol releasing
 plastic, flexible device inserted in uterus
 inserted within 7 days of menses onset OR 6 weeks postpartum
 provides protection up to 5 years
 lighter periods or none
 uterine cramps, bleeding
 MD check placement 1-3 months after insertion and annually
 the only patients that this product was studied in where those who have had at least one child
 rare complication:  can go through the uterus
 if someone was to get pregnant on Mirena they are at risk for ectopic pregnancy (progesterone component); can burst the fallopian tube
 
 2) Paraguard - copper releasing
 prevents sperm from reaching and fertilizing the egg
 no hormones avoids weight gain and mood swings
 |  | 
        |  | 
        
        | Term 
 
        | 2 types of emergency contraceptive pills |  | Definition 
 
        | combined oral contraceptive pills (COCs) YUZPE method:  have to take 4-5 pills to get enough progestin component to prevent pregnancy; at the same time you are getting a lot of estrogen (causes a lot of ADRs - nausea, headache, vomiting, clotting); not FDA approved
 
 progestin-only contraceptive pills (POPs)
 most common
 ex) Plan B
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | abortifacient:  FALSE harms developing fetus:  FALSE
 
 prevents or delays ovulation
 prevents pregnancy from occurring
 
 if pregnancy has occurred it will not harm the fetus
 
 EC prevents implantation by delaying or preventing ovulation
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | PREVENT PREGNANCY 
 not an abortifacient, does not disrupt an implanted pregnancy
 
 if taken before ovulation, EC disrupts normal follicular development and maturation, blocks LH surge, inhibits ovulation
 
 alter endometrium to help inhibit implantation (proposed)
 
 may affect tubal transport of sperm or ova if taken after ovulation (proposed)
 
 works the best if taken before ovulation
 
 will not disrupt a current pregnancy
 |  | 
        |  | 
        
        | Term 
 
        | Plan B emercency kit clinical pearls |  | Definition 
 
        | 2 white tablets of levonorgestrel 0.75 mg (each) 
 1 tablet within 72 hours of unprotected sex then 1 tablet 12 hours later
 
 may take both at the same time
 
 stops 89% of pregnancy if taken within 72 hours
 
 95% if used within 24 hours
 
 effectiveness is greater the sooner it is taken
 
 Plan B is available without prescription for patients 17 years or older
 
 prescription required for patients 16 years old and younger
 
 DOES NOT WORK IF PREGNANT
 
 prevents or disrupts ovulation and fertilization
 
 NOT effective once fertilization or implantation occurs
 
 Patient Education:
 may notice changes in menstrual bleeding after taking Plan B
 if menses is delayed more than 1 week, pregnancy should be suspected
 
 common ADRs:
 nausea, abdominal pain, fatigue, headache, menstrual changes, dizziness, breast tenderness, vomiting and diarrhea
 if they vomit within 2 hours, should take another pill
 |  | 
        |  | 
        
        | Term 
 
        | One-step Plan B clinical pearls |  | Definition 
 
        | levonorgestrel 1.5 mg 
 take within 72 hours of unprotected sex
 
 same SE as 2 step Plan B
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | ulipristal acetate 30 mg 
 progesterone agonist/antagonist
 selective progesterone receptor modulator (SPRM)
 
 delays or inhibits ovulation
 
 can prevent pregnancy up to 120 hours after intercourse
 
 same SE as Plan B
 
 when taken before the LH surge ovulation is delayed by 5 days in 100% of women; when taken after the LH surge ovulation is delayed in 8% of women
 
 overall, 60% effectiveness
 
 after 72 hours with Ella the effectiveness is the same as at 24 hours
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | ~20 different COCs that can be used as EC 
 take 1st dose withint 72 hours, then follow with 2nd dose 12 hours later
 
 nausea (~50%); vomiting (~19%)
 may pre-treat with antiemetic
 
 NOT RECOMMENDED!!
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | levonorgestrel vs. COCs 
 levonorgestrel more effective
 levonorgestrel less side effects (no estrogen)
 
 Plan B is the better choice!!
 |  | 
        |  | 
        
        | Term 
 
        | when in cycle should EC be offered? |  | Definition 
 
        | at any time during the cycle 
 worry about effectiveness of Ella in the 2nd half of the cycle
 |  | 
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        | Term 
 
        | how many times a year can a women use ECPs? |  | Definition 
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        | Term 
 
        | if patient is pregnancy, will EC affect the fetus or pregnancy? |  | Definition 
 
        | no, the hCG will overtake the other hormones |  | 
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        | Term 
 
        | starting contraceptives after EC use |  | Definition 
 
        | should start regular method immediately 
 COCs:  may start next day with 7 day backup method or wait for next menses
 
 POPs:  start on 1st day of menses
 
 start barrier methods immediately, if preferred method
 
 Ella:  when restarting contraceptives (since it is a PR antagonist) there could be competition; the hormonal contraceptive could have decreased effectiveness (use 7 day backup no matter when they start!)
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        | Term 
 
        | pharmacist's right to refuse |  | Definition 
 
        | the Health Care Right of Conscience Act states that not all people have the same moral or religious beliefs about what actions are medically acceptable and therefore issues state policy that Illinois will protect the right of conscience for any person who refuses to deliver, dispense, or pay for , or arrange a medical procedure, device, or other medical service if it conflicts with their personal moral or religious beliefs |  | 
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        | Term 
 
        | Sexual Assault Survivors Emergency Treatment Act of Illinois |  | Definition 
 
        | hospitals must have approved plan for sexual assault victims 
 oral and written information about EC
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