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Meningitis
Therapeutics (V) Exam 3
20
Other
Not Applicable
01/26/2013
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Term
Most common pathogens to cause meningitis
 Definition
  1. Strep pneumoniae
  2. Neisseria meningitidis
  3. Group B strep
  4. Listeria monocytogenes
  5. H. Influenza
Term
What is the classic triad?
 Definition
  • fever
  • nuchal rigidity (pain in the neck)
  • altered mental status
Term

Treatment for neonates

  • Pathogens
  • Emperic therapy
 Definition
  • S. agalactiae, <->, Listeria
  • Ampacillin + cefotaxine or
  • Ampacillin + aminoglycosides
Term

Treatment for 1 month -23 months

  • Pathogens
  • Emperic therapy
 Definition
  • S. pneumoniae, N. meningitides
  • Vancomycin + Ceftriaxone/cefotaxine
Term

Treatment for 2 years -50 years

  • Pathogens
  • Emperic therapy
 Definition
  • N. meningitidis, S. pneumoniae
  • Vancomycin + Ceftriaxone/Cefotaxine
Term

Treatment for >50 years

  • Pathogens
  • Emperic therapy
 Definition
  • S. Pneumoniae, N. meningitidis, Listeria
  • Vancomycin + ampicillin + Ceftriaxone/Cefotaxine
Term

Treatment for immunocompromised

  • Pathogens
  • Emperic therapy
 Definition
  • S. pneumoniae, N. meningitidis, Pseudomonas 
  • Vanco + Cefepine or
  • Vanco + Ceftazedine or
  • Vanco + Meropenam
Term

Treatment for skull fracture

  • Pathogens
  • Emperic therapy
 Definition
  • S. pneumoniae, H. Influenza
  • Vanco + Ceftriaxone/Cefotaxine
Term

Treatment for post neurosurgery, CSF shunt, penetrating trama

  • Pathogens
  • Emperic therapy
 Definition
  • S. aureus, S. epidermidis, pseudomonas
  • Vanco + Cefepine or
  • Venco + Ceftazidine or
  • Vanco + Meropenem
Term

Neisseria

  • Drug
  • Treatment duration
 Definition
  • Ceftriaxone/Cefotaxine
  • 7 days
Term

Haemophilus

  • Drug
  • Treatment duration
 Definition
  • Ceftriaxone/Cefotaxine
  • 7 days
Term

S. pneumoniae

  • Drug
  • Treatment duration
 Definition
  • Ceftriaxone/Cefotaxine
  • 10-14 days
Term

S. Agalactiae (GBS)

  • Drug
  • Treatment duration
 Definition
  • 1. Ampicillin 2. 3rd ceph
  • 14-21 days
Term

Aerobic <-> bacilli

  • Drug
  • Treatment duration
 Definition
  • Ceftriaxone/Cefotaxine
  • 21 days
Term

Listeria

  • Drug
  • Treatment duration
 Definition
  • Ampicillin
  • ≥ 21 days
Term

Pathogens to use steroid for

  • Drug
  • Children
  • Adult
 Definition
  • Dexamethasone
  • HIB
  • S. pneumoniae
Term

Fungal meningitis

  • Treatment
 Definition
  • Amphotericin + Flucytosine
Term

Encephalitis

  • Treatment
 Definition
  • Acyclovir or
  • Foscarnate
Term
H. Influenza Chemoprophylaxis
 Definition
  • Rifampin X4 days
Term

N. Meningitidis Chemoprophylaxis

  • Children
  • Adult
 Definition
  • Rifampin X 2-4 days
  • Rifampin X2 days or Cipro or Ceftriaxone
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