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intensive management of diabetes reduces risk of complications. retinopaty 76% nephropathy 56% neuropathy 60% |
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| Observational follow-up of the DCCT. intensive mgmnt reduces risk of cardio vascular disease by 42%, and heart attack and stroke 57% |
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| intensive mgmnt of TYPE 2 dibests reduces risk of microvascular comps by 25% for each 1 % reduction in HbA1c |
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| CSII reduces risk of hypo events 6 fold in first year, and 4 fold in years 2-4 |
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| type 1 patients require on average 5.2 different basal rates |
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| 16 week study comparing CSII to MDI. A1c's dropped from 8.1 to 7.2 in pump group, compared to 8.2 to 8.1 in the MDI group. 75% of the MDI group swithced to pump therapy. |
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| 93% of patients prefer pump therapy. |
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| study showed significant reduction in A1c and TDD in type 2 patients |
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| Patients were treated with MDI or CSII. after 18 week treatment, and 12 week washout, patients switched treatments. Patients switching from MDI to CSI had an avg A1c reduction of .8%, compared to a .4% increase in in A1c for CSII's switching to MDI therapy. |
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From PPT. Advantages of CSII. - Fewer unexpected fluctuations in glycemic control - more reliable pharmokinetic insulin delivery - lower insulin reqts. - programmable basal rates - enhanced quality of life - patients prefer pump therapy |
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| 3 randomized groups: Continuous guardian usage, biweekly guard usage, conventional SMBG group. - after 3 months, 50% of continuous cgm group had reduction of > 1% reduction in A1c. - 26% of patients on continuous cgm had reduction in A1c of >2% |
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