Term
|
Definition
| Class: salicylate. weakly COX 1 selective, mainly for cardiovascular usage but incorporated into a number of combo drugs. + anti platelet. irreversible. |
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Term
|
Definition
| class: coxib. Moderately COX 2 selective with fewer GI effects. antiinflam |
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Term
|
Definition
| class: propionate. weakly COX 1 selective, suitable for paediatrics . antiinflam |
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Term
|
Definition
| class: pyrrolizine. Highly COX 1 selective. |
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Term
|
Definition
| Propionate. Weakly cox 1 selective. |
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Term
|
Definition
| coxib. highly COX2 selective. |
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Term
| The cyclooxygenase inhibitors? |
|
Definition
antiinflammatories. 1 is systemicinvolved in gastric protection (prostaglandins), platelet aggregation, renal blood flow.
2 is responsible for mainly inflammation.
There is a lot of overlap of function. |
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Term
|
Definition
| anti-inflammatory (prevent vasodilation and oedema), antipyretic (reset the thermostat), analgesic (decrease sensitisation of noiciceptors.. |
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Term
|
Definition
elderly are more vulnerable. GASTROINTESTINAL DISTURBANCES (prostaglandins are supposed to inhibit acid secretion and protect mucosa). gastric discomfort, dyspepsia, constipation, diarrhoea, ulceration and perforation.
Skin reactions
acute renal insufficiency in susceptible patients, decreases renal blood flow
Cardiovascular |
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|
Term
| Paracetamol (acetominophen) |
|
Definition
| antipyretic is the main action + analgesic. toxicosis --> hepatotoxicity, nausea, vomiting in 24-48 hrs. |
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Term
|
Definition
| is an autoimmune arthritis characterised by progressive joint ankylosis and severe disability. |
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Term
|
Definition
| Pain management (NSAIDs), antiinflammatory drugs (corticosteroids), DMARDS |
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Term
|
Definition
| an antimalarial indicated for complex resistant RA, when other therapies fail. ocular toxicity. |
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Term
|
Definition
| first line DMARD for RA (+ psoriasis, crohns and cancer treatment). folate antagonist, most rapid onset, closely monitored for blood dyscrasias |
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Term
|
Definition
| used when other therapy fails (and in transplant rejection). immunosuppresants. |
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Term
|
Definition
| when other therapy fails and some skin disease. immunosuppresants. |
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Term
|
Definition
| RA and psoriatic arthritis. immunosuppresants. |
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Term
|
Definition
| used for severe RA. immunosuppresants. |
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Term
|
Definition
| first line drug in RA and UC. DMARD. produces remission . AES malaise, GI and headache. + impaired folic acid absorption. |
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Term
|
Definition
| the anticytokines are monoclanal antibodies like adalimumab, etanercept, infliximab they target proinflammatory cytokines and the cells that produce them. |
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Term
|
Definition
| inhibits uric acid synthesis and is indicated in gout. |
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Term
|
Definition
| increases uric acid excretion in the kidneys, indicated in gout. |
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Term
|
Definition
| needs and antigout med + pain and antiinflamm (NSAIDs). antigout needs to be started prophylactically. |
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Term
|
Definition
| indicated in the acute aggresive treatment of gout. |
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Term
|
Definition
| is non sedating antihistamine, cardio safe |
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Term
|
Definition
| is non sedation, may cause cardio AEs. |
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Term
|
Definition
| is a sedating antihistamine indicated in nausea and vomiting and motion sickness. |
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Term
|
Definition
| not to be taken with grapefruit juice. clinical use is for allergic reaction, as anti emetics and for sedation. may cause dizziness, fatigue, blurred vision, constipation, urinary retntion. |
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