Term
| saprophytic/environmental phase |
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Definition
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Term
|
Definition
|
|
Term
| importance of tissue phase |
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Definition
| adaptive response, not a necessary component of life cycle |
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|
Term
| Portal of entry for dimorphics |
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Definition
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|
Term
| tissue phase transmissibility |
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Definition
| NOT transmissible, no person-person contact |
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|
Term
| primary dimorphic infection |
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Definition
| benign and self limiting unless in immunocompromised |
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|
Term
| humoral response to dimorphs |
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Definition
| minimal role, useful for diagnosis |
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|
Term
| cell-mediate response to dimorphs |
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Definition
| primary protective mechanism, major determinant of disease severity |
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|
Term
| inhalation, desert areas of Southwest US, present with erythema nodosum (allergic) and mild flu-like symptoms |
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Definition
| Coccidioidomycosis; C. immitis (CA) and C. posadasii (TX,AZ) |
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|
Term
| mould phase: barrel-shaped arthroconidia with disjunctor water cells |
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Definition
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|
Term
| tissue phase: multinucleated spherules that produce endospores |
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Definition
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|
Term
|
Definition
| disseminated disease in immunosuppressed; resolution proven by DTH response to coccidioidin (skin test antige) |
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Term
|
Definition
| none unless extrapulmonary, then give itraconazole |
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Term
| inhalation, self-limiting pulmonary disease that spreads in AIDS patients, Mississippi river valley, bat/bird shit |
|
Definition
| histoplasmosis (histoplasma capsulatum)AKA Darling's Disease |
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|
Term
| Mould phase: microconidia (infectious) and tuberculated macroconidia (diagnostic) |
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Definition
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|
Term
| tissue phase of histoplasma |
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Definition
| causes oval yeasts found in monocytes, macrophages esp in blood, lungs |
|
|
Term
| immunity to histoplasmosis |
|
Definition
| granulomas with DTH response to histoplasmin |
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|
Term
|
Definition
| none, if moderate give itraconazole, and if severe give amphotericin B |
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|
Term
| Inhalation, pulmonary disease; microabscess formation, papulopustular nodules, verrucous granulomas; mississippi/ohio river valleys |
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Definition
| Blastomyces dermatitidis (North american blastomycosis) AKA Gilchrist's Disease |
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|
Term
| Extrapulmonary blastomycosis |
|
Definition
| chronic infection of skin and bones |
|
|
Term
|
Definition
| infection of CNS and UG system |
|
|
Term
| tissue phase: thick-walled yeast with broad based bud |
|
Definition
|
|
Term
| therapy for N.A. blastomycosis (Gilchrist's) |
|
Definition
| itraconazole, amphotericin B |
|
|
Term
| pulmonary infection that spreads to form ulcerative granulomas of buccal/nasal/GI mucosa; lymph nodes often involved; Central/South America |
|
Definition
| Paracoccidioides brasiliensis (South American blastomycosis) |
|
|
Term
| Tissue phase: ship's wheel |
|
Definition
| Paracoccidioides brasilensis --> mould phase looks exactly like B. dermatitidis |
|
|
Term
| lab diagnosis of S.A. blostomycosis |
|
Definition
| cultivation of mould phase on solid media then do a dimorphic conversion to rule out Blastomyces dermatitidis |
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|
Term
| inhalation followed by disseminated disease; HIV pts in Southeast Asia; molluscum contagiosum-like lesions of face and trunk |
|
Definition
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|
Term
| Mould phase: colonies have diffusible red pigment |
|
Definition
|
|
Term
| treatment for penicilliosis marneffei |
|
Definition
| Amphotericin B followed by itraconazole |
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