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Medical Botany
Review exam 2
64
Science
Undergraduate 4
02/25/2014

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Term
Glaucoma
Definition
Disease due to increased intraocular pressure causing vision defects
Term
Pilocarpus jaborandi and microphyllus(Pilocarpine) Rutaceae family
Definition

Mimics acetylcholine, contracts ciliary muscle and reduces intraocular pressure

 

compound leaves. Plantation now being established to prevent extinction.  Obtained from leaflets.

Term
Physotigma venenosum- bean Physostigmine
Definition
Acts indirectly by inhibition of cholinesterase( an enzyme that destroys acetylcholine).  Stimulates both nicotinic and muscarinic receptors.
Term
Cataracts
Definition

Opacity of the lens, which can cause blindness.

 

Treated by surgery or lens replacement

Term
Cornus sericea and hydrocotyle spp.
Definition
Used for treating cataracts
Term
Describe how Aloe vera affects the gastrointestinal system.
Definition
It's a purgative, contains aloin.  Enzymatically hydrolyzed in colon by bacteria, forms aloe-emodin, absorbed by colon, and increases intestinal mobility. action can be sudden.
Term
Cassia and senna spp.
Definition
Produce ex-lax
Term
Ex-lax
Definition
Sennoside A & B enzymatically hydrolyzed by colon bacteria, release laxative compounds, and increases intestinal mobility.  Not sudden action
Term
Plantago ovate or psyllium plantains.
Definition
produce metamucil
Term
Metamucil
Definition
Seeds absorb water, act as laxative increase stool volume and encourage normal reflux activity
Term
Two main hormones of Pituitary gland
Definition
Luteinizing hormone and follicle stimulating hormone
Term
LH
Definition

Female-Triggers ovulation and development of copus luteum

Male-triggers testosterone production in testes, inhibits further release of LH and FSH.

Term
FSH
Definition

Female-Stimulates ovary to produce estradiol

Male- acts directly on testes cells, stimulates sperm production.

Term
Progesterone
Definition
Female specific hormone: Causes blood vessels to grow rapidly in endometrium
Term
Estrogen
Definition
Female specific hormone:  Stimulates growth of endometrium in uterus
Term
Queen Anne's Lace(Daucus carota) was used by the early Greeks and Romans for what reproductive function?
Definition

"morning after" pill.  Seeds block synthesis of progesterone, necessary for endometrium development, results in no implantation. 

-root also used to encourage delayed menstraution.

Term
Nutmeg and mace(from Myristica fragrans) are used medicinally for what purpose?
Definition
Medicinally used as an abortifacient and induces menstration.
Term
Nutmeg used recreationally for....
Definition
used as a hallucinogen, enhances norepinephrine by inhibiting MAO.
Term
Reproductive sterility in females can be obtained through treatment with what plant species?
Definition
Hibiscus rosa-sinensis(Malvaceae) fresh buds taken orally mixed with water from washing rice.
Term
Ergonovine is obtained from what organism?
Definition
Ergot (Glaviceps purpurea): Used to treat post-partum bleeding, contraction of uterine blood vessels.
Term
What are the effects of Mexican Zoapatle (Montanoa tomentosa) on female reproduction?
Definition
Induces menstratioin, induces labor, and contraception. no effect on hormone level.
Term
Breast milk, compared to powdered formula?
Definition

Breast milk fed babies have lower risk of asthma, diabetes, ear infections, and SIDS than formula fed babies.

It is also easier to digest and potentially higher IQ.

Breast milk is worth a lot.  $3.52 an ounce, $96 a day.

Term
How is milk production regulated in the female body?
Definition
Colostrum: first milk, full of immunoglobulins, regular milk comes 3-5 days after birth.  Alveoli cells make milk in response to prolactin.
Term
How does the herbal galactagogue fenugreek(Trigonella foenum-graecum) affect milk production and birth weight of newborns?
Definition
Increase milk production
Term
how are practices in India different fro those of Western Medicine? What are key concepts of Ayurvedic medicine?
Definition

-       Homeopathic, folk or herbal remedies, spiritualists (don’t use plants), traditional psychotherapy (incantations, ritual dances), and synergy – comparison with modern medicine (single compound).

-       Western medicine= our traditional conventions.

1.     Universal interconnectedness (people, health, and the universe)

2.     The body’s constitution (prakriti)

 

3.     Life forces (dosha)- similar to biologic humors of the ancient Greek system.

Term
Curcuma longa, aka turmeric
Definition

Contains the active compound curcuin

Many uses: remedy for stomach and liver ailments, fever, diseases and conditions dealing with skin and gastrointestinal system, aches and pains.

Term
Azadirachta indica(Neem)
Definition
In India was used as a vaginal spermicide.  Direct applicatioin of neem oil immobilizes sperm within 20-30 secs.
Term
Why are spices used in Indian cooking?
Definition
Prevention
Term
Successful male fertility requires what three characteristics of sperm?
Definition

Number: normal=20 million per ml, infertile=<4 mil/ml

Motility: normal=at least 50% moving forward

Morphology: normal=at least 30%

Term
Gossypium spp.  Chinese cotton(Malvaceae)
Definition

contains active compound Gossypol.  Used in China for male contraception.  Reduces sperm # and motility.  

 

Inhibition of sperm motility by blocking ATP production, by suppressing O2 in mitochondria, prevents protein formatioin

 

Another mechanism is spermatogenesis is altered because Ca channels are inhibited.

Term
Testosterone injection:
Definition
Recreational drug- Elimination of sperm from semen, testosterone production in testes inhibits further release of LH, FSH through neg feedback.
Term
Marijuana on mal fertility.
Definition
Less semen, fewer sperm, and moving too fast, too early causing hem to burn out.
Term
Although often touted as a plant aphrodisiac, the Love Bean(Abrus precatorius) detrimentally affects male reproduction in what ways?
Definition

1) Sperm concentration decreases

2) Impared sperm motility

3) Structual abnormalities of sperm

Term
How and why are coca leaves (Erythroxylum coca) used in South America
Definition
Leaves chewed daily as quid.
Term

Coca- Cola contains stimulants from what two plants?

what are the stimulants?

Definition
Cola acuminate and nitida.
Term
Cocaines effects on CNS?
Definition

1) Local effects: inhibits permeability of neuron membranes to Na, blocks initiation and transmission of signals, anesthetic

2) Stimulating effects(brain,lungs,heart) -Blocks synaptic reuptake of norepinephrine and dopamine, NT excess, stimulation.  Usually short duration-sympathetic nervous system.

Term
Canthinone is derived from what stimulatory plant species?
Definition
Khat
Term
Khat (Catha edulis)
Definition
stimulates release of norepinephrine, epinephrine and dopamine, breaks down in body to cathine( accelerates sperm development in mice).  Action reversed by resperine.
Term
How does ephedrine act as a stimulant?
Definition
Mimics sympathetic activity(adrenergic drug) increase release and blocks reuptake or norepinephrine(bronchioles dilate, heart rate increases, and pupil increases)
Term
Caffeine found in what drinks and food?
Definition
Coffee, tea , and chocolate.
Term
What plant species is the highest amount of caffeine naturally found?
Definition
Ilex guayusa-Holly tree
Term
Does caffeine and theobromine affect animals?
Definition
Caffeine and theobromine can be fatal to animals.  Belived to be used as a natural protection against insects.
Term
Are all chocolates fatal to dogs?
Definition
No, it depends on the chocolate type and how much they consume.  Most fatal or potent is Baker's chocolate.
Term
Characteristics of depressant:
Definition

Additive

antagonistic

dosage effects

dependency

(low doses=excitement, high doses drowsiness)

Term
plant species with depressant effects?
Definition

 

  1. Opiates= papaver somniferum, Lactuca quercina and virosa, and Avena sativa (oats)
  2. Kava= piper methysticum
  3. Tranquilizers= rauvolfia serpentine
  4. Alcohol
Term
Two types of methodes used for preparing kava?
Definition

1.      

 

  1. Chewing- roots chopped, chewed in mouth, mixed with cold water or coconut milk, foamy liquid strained and served. Produces narcotic effects (paralyzes muscles of lower limbs, stimulates/depresses respiration, increases force, decrease rapidity of lower limbs, does not impair mental alertness).
  2. Grating- roots grated, ground with cold water or coconut milk, filtered and served. Stimulant and tonic only, used for medicinal purposes. 
Term
opiates
Definition
Opiates are derived from Papaver somiferum.  Once they were commonly used for children's cough syrup or teething solutioin, used to quiet infants.
Term
Opiates affect on the human body
Definition

Opiates affect the CNS and intestines; less secretion of digestive enzymes, slows passage of food and water is absorbed more quickly.

CNS effects=reduces action potentials and restricts synthesis of NT's, binding to receptors that deal wth pain perception.

Term
Why are tranquilizers used?
Definition
Depress CNS, relieve tension and anxiety-sometimes relax skeletal muscles
Term
Acetylcholine depression
Definition
Solanaceous alkaloids-Datura stramonium , Atropa belladonna
Term
Enhances norepinephrine
Definition
Peyote- Lophophora williamsii(Cactaceae, Nutmeg-Myristica fragrans
Term
Enhances serotonin
Definition
LSD and Ergot(a fungus Claviceps purpurea)
Term
Binds to central receptors
Definition
Marijuana-Cannabis sativa. THC
Term
What are some effects of poisoning with Solanaceaus species such as Datura(Jimsonweed)?
Definition
"Hot as a hare, red as a beet, dry as a bone, blind as a bat and mad as a  hatter"
Term
Why do witches fly?
Definition
Solanaceous plants create mixture and add fat or oil, put mixture on stick and woman get on the stick, begin to hallucinate and believe they are flying.  Genitals very sensitive causing psychoactive thoughts.
Term
Hallucinations involving flying or lycanthropy were most often caused by what type of alkaloids?
Definition
Solanaceous alkaloids
Term
Myristicin is obtained from what spice?  How does it enhance norepinephrine?
Definition
Comes from nutmeg and is found in carrots and parsely.   It enhances norepinephrine by inhibiting monoamine oxidase(MAO)- protein that destroys norepinephrine after use.
Term
What highly hallucinogenic plant was initially derived while scientist were trying to synthesize a more powerful drug from ergonovine?
Definition
LSD
Term
The Salem witch trials of 1692 and St. Anthony's Fire outbreaks were most likely caused by what?
Definition
Ergot- a fungus Claviceps purpurea from wheat.
Term
Mescaline is obtained from which species used by North American tribes?
Definition
Mescaline is obtained from Peyote- Lophophora willaimsii(cactaea).  Comes from Cacti.  It affects the human body by enhancing norepinephrine-1.  Mimics effects of sympathetic nervous system. 2. affects K conductance. 3. Blocks acetylcholine release.
Term
What symptoms of LSD ingestion?
Definition
LSD: enhanced perception(brilliant colors and loud sounds), loss of normal perception boundariies, heightened emotions, less reserved, extreme modd changes, and past memories relived.  LSD is not addictive and tolerance can disappear rapidly.
Term
THC is obtained from?
Definition
THC is obtained from Marijuana(Cannabis Sativa)  THC receptors in the brain(modulates action of other NTs) and also the uterus.
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