Term
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Definition
Metronidazole (Flagyl)
TC: Antibiotic
PC: Nucleic acid synthesis inhibitor
CC: Nitroaryl
Indication: CD - intra-abdominal abscess(fistula)
Note: Carcinogenicity |
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Term
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Definition
Budesonide (Entocort)
TC: Anti-inflammatory/ Glucocorticoid
PC: Glucocorticoid receptor agonist
CC: Corticosteroid
Indication: Acute flare ups of IBD when ASA is inadequate |
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Term
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Definition
Mesalamine (Asacol)
TC:Anti-inflammatory
PC: COX inhibitor (ASA)
CC: 5-ASA salicylate |
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Term
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Definition
Adalimumab (Humira)
TC: Immunosuppressant
PC: TNF-alpha antagonist (Bind TNFa)
CC: Monoclonal antibody |
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Term
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Definition
PEG 3350 (Miralax)
TC: Laxative
PC: Osmotic/ hyperosmolar laxative
MOA: Osmotic agent that causes water to be retained in stools. Increase frequency of bowel movements and volume of stools. Used in occasional diarrhea |
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Term
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Definition
Senna (cassia)/Anthraquinone
TC: Stimulant/irritant laxative
MOA: Direct effects on enterocytes and induce a low grade inflammation that promtoes the accumulation of water and electrolytes and stimulate intestinal motility. |
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Term
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Definition
Methylnatrexone (Relistor)
TC: Anti-constipation
PC: Peripheral Mu opioid receptor antagonist
CC: Opioid
Indication: Treatment of opioid induced constipation in patients with advanced illness who are receiving palliative care not responsive to laxative therapy |
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Term
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Definition
Docusate (Colace)
TC: Anti-constipation
PC: Surfactant/Stool softener
CC: Alkylsuccinate
MOA: Lower surface tension of the stool and allow the mixing of aqueous and fatty substances |
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Term
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Definition
LHyoscyamine (Levsin)
TC: Anti-diarrheal
PC: Muscarinic cholinergic receptor antagonist
CC: Tropane
SAR: Tropane (sterically bulky group) + atropine , belladonna alkaloids |
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Term
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Definition
Dicyclomine (Bentyl)
TC: Anti-diarrheal
PC: Muscarinic cholinergic receptor antagonist
CC: Dicyclohexylester |
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Term
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Definition
Loperamide (Imodium)
TC: Anti-diarrheal
PC: Peripheral mu opioid receptor agonist
CC: Diphenylpiperidine |
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Term
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Definition
Lidocaine (Anamantle-HC)
TC: Anesthetic
PC: Sodium channel blocker
CC: Amide
Indications: Hemmorrhoids |
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Term
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Definition
Brimonidine (Alphagan)
TC: Anti-glaucoma agent
PC: Alpha 2 adrenergic receptor agonists
CC: Imidazoline
MOA: Decreased production of AqH and increased outflow of AqH |
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Term
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Definition
Timolol (Timoptic)
TC: Anti-glaucoma agent
PC: Beta-adrenergic receptor antagonist
CC: Aryloxypropranolamine
MOA: Decreased production of AqH |
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Term
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Definition
Dorzolamide (Trusopt)
TC: Anti-glaucoma agent
PC: Carbonic Anhydrase Inhibitor
CC: aryl-sulfonamide
MOA: Decreased secretion of AqH
SAR: Negatively ionizable (acidic aryl sulfonamide)to interact with active (++) Zinc atom |
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Term
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Definition
Pilocarpine (Isoptocarpine)
TC: Anti-glaucoma agent
PC: Direct cholinergic receptor agonist
CC: Lactam
MOA: Increase outflow of AqH |
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Term
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Definition
Latanoprost (Xalatan)
TC: Anti-glaucoma agent
PC: Prostaglandin receptor agonist
CC: Prostanoid
MOA: Increase outflow of AqH
SAR: Analogs of PGF agonists |
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Term
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Definition
Olopatadine (Patanol)
TC: Antihistamine
PC: Histamine receptor antagonist
CC: Dihydrodibenz[b,e]oxepine
SAR: Aromatic ring -spacer- basic nitrogen |
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Term
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Definition
Cromolyn (Opticrom)
TC: Anti-conjunctivitis agent
PC: Mast cell stabilizer (degranulation inhibitor)
CC: Chromone |
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Term
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Definition
Ketotifen (Zaditor)
TC: Anti-conjunctivitis agent
PC: Mast cell stabilizer (degranulation inhibitor) and histamine receptor antagonist
CC: 4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one |
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Term
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Definition
Tetrahydrozoline (Visine)
TC: Anti-conjunctivitis agent
PC: Alpha 1 receptor agonist (Decongestants -mydriatics)
CC: Phenethylamine
SAR: Phenethylamine core is the key to alpha 2 adrenergic receptor agonism |
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Term
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Definition
Ketorolac (Acular)
TC: Anti-inflammatory agent
PC: COX inhibitor
CC: Arylalkanoic acid
SAR: active forms are arylalkanoic acids |
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