Term
| What are the indications for Levothyroxine (synthroid)? |
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Definition
| Hypothyroidism, Suppression TSH secretion |
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Term
| What are the indications for Topazole (Methimazole)? |
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Definition
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Term
| What are the indications for Zometa? |
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Definition
| Hypercalcemia of malignancy, MM, Osteoporosis |
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Term
| What are the indications for Hydrocortisone? |
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Definition
DOC for Primary and Secondary Adrenal Insufficiency
Allergic Response |
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Term
| What are the indications for Inderal (Propanolol)? |
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Definition
| HTN, Migraine HA, Adjunct Therapy in Pheochromocytoma (used with alpha-blocker) |
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Term
| What are the indications for Phenoxybenzamine? |
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Definition
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Term
| Which drug has SE including weight loss, heat intolerance, fever, sweating, tachycardia, impaired fertility, and decreased bone density? |
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Definition
| Levothyroxine (Synthroid) |
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Term
| What drugs does Levothyroxine (synthroid) interact with? |
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Definition
OCs
Estrogen - HRT
ASA
Nitroprussides
Thiazide Diuretics
Sulfonamides
Antacids
Colestipole
B-Blockers (esp. propranolol)
NSAIDs
Anti-Depressants
Insulin
Oral-hyperglycemic agents
Theophyllin |
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Term
| What drug has SE including aplastic anemia, lupus-like syndrome, hepatitis and nephritis? |
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Definition
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Term
| What drugs does Topazole (Methimazole) interact with? |
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Definition
Anticoagulants
Digitalis
B-Blockers
Theophylline |
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Term
| Which drug gives SE of fever and flu-like symptoms that can be prevented by giving Tylenol prophylactically? |
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Definition
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Term
| Which drug has SE including slow wound healing, decreased glucose tolerance, hepatomegaly, pathologic fractures, tendon rupture (with injection into tendon), papilledema, and personality changes? |
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Definition
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Term
| Which drugs interact with Hydrocortisone? |
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Definition
NSAIDs
Erythromycin
Ketoconazole
anti-coagulants
Macrolides
Anti-diabetic meds
Estrogens and OCs |
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Term
| What drugs does Propranolol (Inderal) interact with? |
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Definition
CCB
ACE I
NSAIDs
Anti-depressants
Thyroxine (T4 or Synthroid)
Alcohol
Tagament
Ciprofloaxin
Theophylline |
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Term
| Which drug has SE including postural hypotension and pupil constriction? |
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Definition
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Term
| What is the treatment for Gigantism/Acromegaly due to excessive GH? |
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Definition
| Dostenex 0.25mg PO twice weekly. (Max dose 1mg twice weekly) |
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Term
| What is the treatment for central DI? |
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Definition
| DDAVP (Desmopressin Acetate) 0.05mg PO BID (Max Dose = .4mg PO q8h) |
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Term
| What is the treatment for Addison's disease? |
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Definition
| Hydrocortisone 15 - 20mg PO AM, 10 mg PO 4-5 PM |
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Term
| What is the treatment for Acute AI? |
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Definition
Hydrocortisone 100 - 300mcg IV w/D5w
Broad Spectrum Anti-biotics |
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Term
| What is the treatment for Hyperprolactinemia? |
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Definition
| Cabergoline (Dostinex) 0.25mg PO 2x per week, then increase by .25 twice weekly after 4 weeks; Max Dose 1mg 2x per week |
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Term
| If there is a growth hormone deficiency, what is the pediatric and adult dosages for GH? |
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Definition
Ped - 0.025mg/kg SC daily
Adult - 0.3 - 1.25mg SC daily |
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Term
| What is the treatment for Nelson's Dx? |
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Definition
| Glucocorticoids (hydrocortisone) 15 - 20 mg/d PO/IV/IM divided BID |
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Term
| What is the treatment for Hyperparathyroidism? |
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Definition
IV Hydration
IV Biphosphenates -Zoledronic acid 2 - 4 mg IV over 15 - 20 min
Calcimimetics - Cinacalcet hydrochloride 30 - 250mg PO qid (decreases secretion of PTH)
Vitamin D 800 - 2000 units orally qd |
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Term
| What is the treatment for Hypoparathyroidism? |
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Definition
IV Calcium gluconate: 10% solution 10 - 20mL given slowly until tetany ceases then IV drip 10 - 50mL of 10% calcium gluconate in 1L of 5% glucose saline until serum Ca is 8 - 9 mg/dL
Calcium Salts PO 1-2g qd
Calcitriol PO 0.25mcg q AM then titrate to .5 - 2mcg/d
Magnesium sulfate IV 1 - 2 g q6h then d/c and give Magnesium oxide tabs 600mg PO 1-2x qd |
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Term
| What is the DOC for hyperthyroidism during pregnancy and breast feeding? |
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Definition
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Term
| What is the treatment for hyperthyroidism if the pt is not pregnant or breast feeding? |
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Definition
Methimazole (Tapazole)
Mild/Initial Dose = 15mg
Moderate/Intitial Dose = 30 - 40mg
Severe/Initial Dose = 60mg(divide into 3 equal doses 8 h apart) |
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Term
| What is the treatment for Grave's Disease? |
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Definition
Methimazole (Tapazole) Mild: 15 - 20mg; Moderate: 30 - 40mg; Severe: 60mg
Propylthiouracil - DOC for pregnant or breast feeding pts
Propranolol 20mg PO qd, gradually increase to 20 -40 mg QID or until symptoms stop |
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Term
| What is the treatment for Hasimoto's Dx? |
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Definition
| Levothyroxine (synthroid) 1.7mcg/kg/d; increase by 25mcg/d q 4 - 6 wks until TSH is normal; Elderly = 1 mcg/kg/d |
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Term
| What is the treatment for Thyroid Storm? |
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Definition
Thiourea (Methimazole)v15 - 25mg PO q6h
or Propylthiouracil 150 - 250mg PO q6h
Hydrocortisone 50mg PO q6h - rapid dose reduction once pt improves clinically |
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Term
| What is the treatment for Hypothyroidism? |
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Definition
Levothyroxine (Synthroid) 1.7mcg/kg/d; increased by 25mcg/d q 4-6 weeks until TSH is normal
Elderly dose - 2/3 of regular dose to start - Over 50y/o start at 1mcg/kg/d |
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Term
| What is the treatment for Sheehan's syndrome? |
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Definition
Levothyroxine (Synthroid)1.7mcg/kg/d; increase by 25mg q 4-6 weeks (If TSH or T4 is LOW)
Hydrocortisone 50mg PO q6h (if ACTH is LOW)
Estrogen/Progesterone - If LOW
GH 0.3 - 1.25mg SC daily (adult dose)- If LOW |
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Term
| What is the treatment for Acute Adrenal Insufficiency? |
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Definition
| Hydrocortisone 100 - 300 mg IV and saline (containing 5% dextrose), then hydrocortisone phosphate or hydrocortisone sodium succinate 100mg IV immediately, then continue IV infusion of 50 -100mg q6h for the first 24h then 50 - 100mg q8h for the second day |
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Term
| What is the treatment for Chronic Adrenal Insufficiency? |
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Definition
DOC - Hydrocortisone 15 - 20mg PO q AM, 10mg PO at 4 PM
Dehydroepiandosterone (DHEA) 25 - 50mg PO once daily in AM |
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Term
| What is the treatment for Hypoaldosteronism? |
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Definition
| Fludrocortisone 0.05 - 0.10 mg PO qid |
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Term
| What is the treatment for Pheochromocytoma? |
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Definition
| Dibenzyline/Phenoxybenzamine Initial dose 10mg PO BID, increased every other day; usually 20 -40 mg PO BID or TID |
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