Term
Coccidioides Immitis
Coccidioidmycosis
"VALLEY FEVER" |
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Definition
Arthroconidia
Spherules filled with endospores
NO YEAST FERM
Clinical: Self limit flu like => PN Chronic Cavernous Lung Granulomatous lesions in skin (DESERT BUMPS) bones and CNS Dissemination inf of AIDS ICP and prego D(x)- Spherules Culture - Hyphae I Barrel-shaped arthroconida |
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Term
Histoplasma Capsulatum
Histoplasmosis |
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Definition
Soil Bird bat feces
env- hyphae w/ mito and tubercualate macroconidia
tissue- SMALL budding yeasts parasites in reticuloendothelial cells
clinical: Acute PN, Disseminated Histoplasmosis
Microscopy: Small individual yeast cells inside Macrophage
Culture: THERMAL DIMORPHISM
Hyphae w/ microconidia and tuberculate macroconidia |
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Term
Blastomyces Dermatitidis
Blastomycosis |
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Definition
Env- white=tan filamentous mold colonies
Septate hyphae w/ nondescript conidia
Tissue- Single broad based budding yeasts
thick double contoured wall
Dogs
Clinical: Pulm D(s), Dissemination => Skin and bones
Microscopy: thick walled single broad based budding yeast
Culture: THERMAL DIMORPHISM |
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Term
Paracoccidioides Basiliensis
Paracoccidioidmycosis |
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Definition
Env: Hyphae and Conidia
Tis: Thick walled yeasts, budding cells PILOT WHEEL
Clinical: Pulm- cough, sputum, chest pain
dissem- ulcerative granulomas of buccal, nasal, GI mucosa
Micro - PILOT WHEEL
Culture THERMAL DIMORPH hyphae and conidia |
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Term
Coccidioidomycosis, Histoplasmosis, Blastomycosis, Paracoccidioidomycosis
Characteristics |
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Definition
Endemic Mycoses
True Pathogens
Primary Pulmonary
No Human --> human
Dimorphic Fungi |
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Term
Coccidioidomycosis, Histoplasmosis, Blastomycosis, Paracoccidioidomycosis
D(X) |
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Definition
Serologic Tests
antibody
complement
Gell precipitate
latex agglutination
Skin Tests
Type 4 hypersense
(coccidioidin - initial orientation test if an inf suspected) |
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Term
Coccidioidomycosis, Histoplasmosis, Blastomycosis, Paracoccidioidomycosis
T(X) |
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Definition
depends on form severity and immunity
mild -> mod = Azole derivative
Sev -> dissem = Amphotericin B |
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Term
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Definition
Pigeon Shit
Encapsulated yeast - polysach capsule
Oportunistic mycosis - cryptococcosis
-pulm inf, meningitis (affinity for CNS)
DX: blood CSF biopsy
micro- Encapsulated yeasts India ink-THICK HALO
Culture: mucoid colon, urease +
detect cap antigen
TX: amphoterecen B
w/ flucytosine |
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Term
Aspergillus Fumigatus and Flavus |
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Definition
Filamentous Fungus
Opertunistic Mycosis - Aspergillosis
- RT, endophthalmitis, CNS, septic
- Immunosuppression
ANGIOVASIVE FUNGII
allergic bronchopulm asperation (ASTHMA
Fungal Ball, aspergilloma
Invasive Pum Aspergillosis (PN or Meningitis) (Cellulitis in burn pts)
DX: Micro- filamentous septate hyphae, typical V-shaped bronches
Culture-rapid growth - fluffy pigmented colony, conodial heads
TX: Amphatericin B |
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Term
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Definition
RHIZOPUS MUCOR --> Filamentous Fungus
Zygomycosis - Rhinocerebral, pulm, GI, Cutaneous (diabetes)
Rhino- diabetic acidosis
pulm- not invasive aspergillosis
DX: Micro- Hyphae = broad, ribbon like, nonseptate
Culture- rapid, grey to brown, fuzzy aerial mycelium
TX: Amphotericin B |
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Term
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Definition
single-celled eukaryotic microorg - no ergosterol in cell membrane
interstitial PN - risk AIDS PTS
Life Cycle - Trophic -> Precyst -> Cyst
DX: org not cultivated
Silver stain --> cyst
X-Ray - patchy infiltration
TX: TMP-SMX |
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Term
| Pneumocystis Jiroveci, Zygomycetes, Aspergillus Fumigatus and Flavus, Cryptococcus Neoformans |
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Definition
Opportunistic Pulm Mycosis
Not true pathogens
Monomorphic |
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