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Med chem exam 2
Exam 2
42
Chemistry
Graduate
01/12/2012

Additional Chemistry Flashcards

 


 

Cards

Term

Duration of β1 antagonists

 

Definition

Ester: shortest acting

Amide: Intermediate acting

Ether: longest acting

Term
[image]
Definition
Aryloxypropanolamine
Term

Tricyclic antidepressents

2° amine:

3° amine:

Definition

2° amine: NE uptake blocker

3° amine: 5HT uptake blocker

Term
[image]
Definition

Cocaine

blocks reuptake of NE & DA

Term
Enzyme that turns L-DOPA into Dopamine
Definition
LAAAD
Term
Rate limiting enzyme for DA synthesis
Definition
Tyrosine Hydroxylase
Term
D1/D5 receptor
Definition
  • Activates adenylate cyclase
  • ↑cAMP
Term
D2, D3, D4
Definition
  • Pre & post synaptic
  • Inhibit adenylate cyclase
  • ↓cAMP
Term
α Rotamer
Definition
  • Same side
  • D1 = D2
Term
β Rotamer
Definition
  • Opposite side
  • D2 > D1
Term
COMT
Definition

(+SAM)

OH -> OCH3

Term
MAO
Definition
amine -> Aldehyde
Term
Aldehyde dehydrogenase
Definition

(+NAD)

Aldehyde -> Carboxylic acid

Term

How do D2 autoreceptors inhibit DA?

 

Definition
  • Inhibit synthesis (Tyrosine hydroxylase)
  • Inhibit release
Term
Basal Ganglia
Definition
  • Substantia Nigra origin of corpus striatum)
  • controls posture, muscle tone, movement
  • Lack = Parkinson's, EPS.
  • (ACH works with DA for balance)
Term
Meso-Limbic system
Definition
  • Behavior & Emotion
  • Too much: Schizophrenia (Psychosis)
  • Too few: Depression
Term
Tubero-infundibular system
Definition
  • Anterior pituitary
  • DA decreases prolactin release
Term
Meso-accumbens pathway
Definition
  • DA controls locomotion
Term
[image]
Definition
  • ↑ DA release
  • ↓ DA uptake

Taken up actively by presynaptic neurons

(Parkinsin's)

Term
[image]
Definition
  • Mimics GABA
  • CNS suppression (↓ DA)
Term
DA agonist uses
Definition
  • Primary: Parkinson's
  • secondary: RLS (Requip/Mirapex)
Term
[image]
Definition

DA agonist

NOTE:

  1. Aromatic ring
  2. Basic N (separated from AR by 2 atoms)
  3. Minimal bulk
  4. α rotomeric
Term
DA antagonist uses
Definition
  • Primary: Antipsychotics
  • Minor: Anti-emetic (Metoclopramide)
  • Adjuvent: Depression/Bipolar
Term
[image]
Definition

Phenothiazine

NOTE

  • S
  • separation of 2-4 between AR and N
  • Cl = EWG = required.
Term

Phenothiazine

Preferd activity

Definition
3º amine > 4º amine > Sulfonium > Thioether
Term
[image]
Definition

Tyrosine Hydroxylase inhibitor

NOTE:

  • Extra methyl group prevents enzyme from acting (reversible inhibition)

Treat pheochromocytoma (excess NE/E)

Term
[image]
Definition

LAAAAD inhibitor

NOTE:

  • Extra methyl group.  converted by LAAAAD into a false NT
  • Presynaptic α2 agonist (↓ BP)

 

Term
α mediates
Definition

smooth muscle contraction

  • Agonist:decongestion, vasoconstriction
  • A1 Antagonist: treat hypertension & BPH
  • A2 Antagonist: treat depression

 

Term
[image]
Definition

Phenethanolamine

NOTE:

OH

Term
[image]
Definition

2-arylImidazoline

NOTE:

C

α1 agonist

Term
[image]
Definition

Phenethylamine (Amphetamine)

NOTE:

no OH

Indirect acting α1 agonist (promote NE release)

Term
[image]
Definition

2-aminoimidazoline (Clonidine)

NOTE:

ortho N, Halogen,

α2 agonist

CNS antihypertensives. 

 

Term
[image]
Definition

Imidazole based α2 agonist

NOTE:

benzene substituants are O & M

Term
[image]
Definition

Imidazoline

NOTE:

No halogen

α antagonist

Term
[image]
Definition

β-Haloalkylamine

α2 antagonist irreversible

NOTE:

ether

Term
[image]
Definition

Quinazoline (Doxazosin, longest acting)

α1 antagonist

 

Term
[image]
Definition
LA β2 agonist
Term
[image]
Definition
LA β2 agonist
Term
[image]
Definition
Super LA β2 agonist
Term
[image]
Definition

Dobutamine

β1 (α1 cancels out)

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