Term
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Definition
| nitro group serves as an electron acceptor; the reduced cytotoxic compounds bind to proteins & DNA, resulting in cell death and inhibition of DNA replication |
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Term
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Definition
| affects cell-signaling pathways and membrane synthesis |
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Term
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Definition
- inhibits trypanothione reductase (a parasite-specific enzyme)
- generates toxic oxygen radicals
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Term
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Definition
| inhibits prokaryote protein synthesis by interfering with the initiation complex and causing misreading of mRNA |
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Term
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Definition
- interacts with nucleotides
- interferes with uptake and function of polyamines
- inhibits dihydrofolate reductase
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Term
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Definition
| inhibits parasite-specific enzymes, such as glycerol phosphate dehydrogenase |
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Term
| trimethoprim-sulfamethoxazole |
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Definition
| inhibit two sequential steps in folic acid synthesis |
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