Term
| State the two key principles foundational to pharmacology that were introduced by Paracelsus. |
|
Definition
1) He was a strong advocate for the curative power of single chemical entities.
2) He promoted the important concept of dose-response relationships for medicinal agents. |
|
|
Term
| Identify the key means by which drug effect is quantified and compared |
|
Definition
1) onset
2) intensity
3) duration |
|
|
Term
|
Definition
| the time at which drug concentration reaches the minimally effective concentration and produces a measurable drug response |
|
|
Term
|
Definition
| the period of time after drug administration during which a measurable drug response occurs |
|
|
Term
|
Definition
| a measure of magnitude of a specific pharmacological effect |
|
|
Term
|
Definition
| the science of the interaction of chemicals with biological systems |
|
|
Term
|
Definition
| the study of absorption, distribution, bio-transformation, and elimination of xenobiotics |
|
|
Term
|
Definition
| the study of the biochemical and physiological effects of xenobiotics and their mechanisms of action |
|
|
Term
| Describe the significance of a graded-dose response |
|
Definition
| increasing doses will achieve a greater response, so adjustments in dose may achieve a better therapeutic outcome |
|
|
Term
| Describe the clinical significance of the difference between drugs and drug products |
|
Definition
As clinicians we administer drug products which usually contain other chemicals besides the drug itself
Drugs are only the active ingredient of a drug product |
|
|
