Term
| What is an actin monomer called? |
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Definition
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Term
| What is an actin polymer called? |
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Definition
| F-actin (for "filamentous") |
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Term
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Definition
| Big bundles of actin found in contractile cells. |
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Term
| What is more rigid: actin or mictotubules? |
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Definition
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Term
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Definition
| It stabilizes microtubules, which is a death sentence for rapidly growing cells. This has been useful in treating breast cancer. |
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Term
| What are kinesins and dyneins? |
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Definition
| Motorproteins that use ATP hydrolysis to move along microtubules. (The "walking video" from class). They can drag along cargo in vesicles, or chromosomes. |
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Term
| What is the mitotic spindle? |
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Definition
| The network of microtubules that radiate from the centrosomes and search around blindly until they find a kinetochore or the other centrosome. |
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Term
| How do sister chromatids separate during anaphase? |
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Definition
| The glue holding them together (cohesins) dissolves and the chromatids can move towards opposing poles. |
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Term
| What is the nuclear lamina? |
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Definition
| The fibrous structure that lines the inner nucleus, made of intermediate filaments. |
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Term
| What type of intermediate filament is seen in cell-cell junction? |
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Definition
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Term
| What are multivesicular bodies? |
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Definition
| Endosomes that are intermediates in receptor-mediated endocytosis. |
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Term
| What stage of actin formation is the slowest? |
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Definition
| Nucleation. This is where the individual actin subunits ("circles") are coming together. |
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Term
| The “classical” signal for nuclear import includes what? |
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Definition
| Multiple, basic amino acids |
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Term
| COPI is usually associated with what? |
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Definition
| Cargo returning from the Golgi to the ER. This is an example of retrograde flux. |
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Term
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Definition
| A GTPase that assists the budding of clathrin-coated vesicles. |
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Term
| What bad thing targets SNARE proteins? |
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Definition
| Neurotoxins secreted by the organisms that cause tetanus and botulism, which block neuronal function by preventing docking. |
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