Term
| which plants have the highest concentration of THC? |
|
Definition
| blooming buds of the female plants: highest concentration of THC |
|
|
Term
| What are the desireable clinical effects? |
|
Definition
|
|
Term
| What are the toxic/cognitive effects? |
|
Definition
| balance, orientation, motivation, memory, perception, consciousness, amotivational syndrome, hallucination, delusions, ataxia and dysmetria in time and space. |
|
|
Term
| what is amotivational syndrome? |
|
Definition
| short term memory disturbance; illusions, derealization, and psychosis |
|
|
Term
| can you kill yourself with THC? |
|
Definition
| relative to heroin or cocaine, LOW |
|
|
Term
| what are the theraputic/somatic effects? |
|
Definition
| antiemetic, reduction of intraoccular tension, analgesic, muscle relaxant, anti-convulsant, anti-inflammatory, increase appetite |
|
|
Term
| what are the toxic side effects? |
|
Definition
| mostly related to smoking rather than to the THC |
|
|
Term
| what do the edogenous cannabinoid levels interact? |
|
Definition
| with leptin and ghrelin in the hypothal and is directly proportional to food deprivation |
|
|
Term
| What are the theraputic uses? |
|
Definition
| aniemetic and ophtalmic theraputic indications |
|
|
Term
| In animals, does THC fulfill the criteria for an addictivel sustance? |
|
Definition
| Preclinical (animal) data shows that THC does fulfill the criteria for an addictive substance (e.g. CPP, reinstatement of drug seeking over time delay, self administration, increase in CRF and brain self stimulation in withdrawal, etc: |
|
|
Term
| what is major active ingredient in marijuana? |
|
Definition
|
|
Term
| What are major active metabolites? |
|
Definition
|
|
Term
| what is major inactive metabolite? |
|
Definition
|
|
Term
| Where is THC metabolized? |
|
Definition
|
|
Term
|
Definition
| Lipophilic: redistributed in fatty tissues and could be released back into circulation |
|
|
Term
|
Definition
| Elimination: 35% urine, 65% feces |
|
|
Term
|
Definition
Screening - Immunoassay in urine: sensitivity threshold is 50 ng/ml, does not discriminate THC from the metabolites
Confirmation - Gas chromatography and other specific methods |
|
|
Term
| How long can a joint last in your urine? |
|
Definition
| Single joint can lead to a positive urine test for 8-96 hrs |
|
|
Term
|
Definition
Dronabinol (Marinol): Synthetic THC
FDA-approved for nausea associated with chemotherapy and for AIDS-related wasting |
|
|
Term
| what are cannabinoid receptors? |
|
Definition
| G protein-coupled, with seven transmembrane regions |
|
|
Term
| Where is CB1's distribution? |
|
Definition
CB1
Brain, fat cells, liver, duodenum, muscle |
|
|
Term
| Where is CB2's distribution? |
|
Definition
CB2
lymphocytes>macrophages>cytokines |
|
|
Term
| What does endocannabinoids bind to? |
|
Definition
|
|
Term
| Do you find CB2 in the brain? CB1? |
|
Definition
|
|
Term
| Where do you find CB1 in the brain? |
|
Definition
Dense:Basal Ganglia, Cerebellum, Hippocampus, NAcc,
Middle Prefrontal and Parietal Cortex
Moderate: Amygdala, Spinal Cord, Brainstem |
|
|
Term
| Are Both cannabinoid receptors are Gi/o protein-coupled? |
|
Definition
|
|
Term
|
Definition
| Depolarization-induced suppression of inhibition |
|
|
Term
|
Definition
"Inhibit the inhibitor"
POSTSYNAPTIC endocannabinoid release inhibits PRESYNAPTIC GABA and glutamate release |
|
|
Term
| what comprises the mesocorticolimbic reward pathway? |
|
Definition
| prefrontal cortex, nucleus accumbens, and ventral tagmental area |
|
|
Term
|
Definition
| synthetic cannabinoid antagonist that produces morphine induced preferences |
|
|
Term
| What is the cannibus theory of obesity? |
|
Definition
Obesity = Hyperactive endocannabinoid system?
Endocannabinoids and cannabis ::
Induce appetite (orexigenesis);
Reduce satiety ;
Stimulate lipogenesis;
Reduce energy expenditure;
Increase hedonic reward value of palatable food
THEREFORE, A CB1 antagonist should have opposite effects… |
|
|
Term
| How would a CB1 antagonist work? |
|
Definition
Blocks the direct reinforcing effects of some drugs of abuse and food;
Blocks the motivational effects (relapse prevention) of most drugs of abuse |
|
|
Term
| what is rimonabant used for? |
|
Definition
| R doubled smoking quit rates |
|
|
