Term
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Definition
| involvemtn of bone marrow and blood, usually imamture cells |
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Term
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Definition
| discrete tumor masses- lymph nodes, extranodal sites. |
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Term
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Definition
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Term
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Definition
| cd marker : cd10 (b cells) |
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Term
| marginal zone (location and markers |
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Definition
| spleen, malt lymphoid tissue, cd5-,cd10- |
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Term
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Definition
| low numbers (cd1-8, no such thing as cd-6) |
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Term
| luekocyte associated antigen |
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Definition
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Term
| lymphoam systemic manifestations and local manifestation |
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Definition
| fever , night sweats, weight loss, pruritis (itching); local: lymphadenopathy, splenmegaly, any tissue infiltration. |
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Term
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Definition
| pancytopenia, cns involvemnt, compresison fo bitals by bulky diseasek, effusion disease |
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Term
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Definition
| hodgkins haveRS cells and march throug hlymph nodes contigiously. |
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Term
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Definition
| b cell, t cell, hodgkisn , and plasma. |
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Term
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Definition
| CLL is blood (leukemia), SLL (node). Older patients, indolent disease. |
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Term
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Definition
| cd19,cd20,cd23,cd 5, mature lymphocytes. |
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Term
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Definition
| smudge cells , completley diffuse, (no follicles involved). |
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Term
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Definition
| very good prognosis, lowest of low grade lymphomas, unless transformed to diffuse large b cell known as richter syndrome. Treatment: Rituxan (antiCd20). |
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Term
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Definition
| most common lymphoma in u.s., resemble normal germinal centers |
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Term
| follicular lymphoma markers/chromosomal |
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Definition
| CD 10 marker, t(14:18) , express Bcl-2 (prrevention of apoptosis)- it is a heterodimer with another protein when it is overexpressed balanced is thrown off |
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Term
| follciular lymphoam clincial presentation: |
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Definition
| generalized lymphadenopathy, no extranodal sites. Incurable, but low grade unless transforms to DLBL. So don’t bother treating unless symptosm start to develop |
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Term
| mantle cell lymphoma markers: |
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Definition
| cd5,cd19, but cd23- , (11,14 chromosomal translocation) (bcl-1, cyclin-d1), |
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Term
| mantle cell clincial presentation |
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Definition
| lymphadenopathy, splenmoegaly. Is indolent though frequently relapses with more resistance ach time. |
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Term
| burkitt lymphoma etiology |
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Definition
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Term
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Definition
| cd10, t(8,14), c-myc gene (imbalance between myc and max).- stay primitive and replicate a lot. |
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Term
| burkitt lymphoma clincal fetures |
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Definition
| extranodal sites common, 30 percent of all childhood lymphomas. AGGRESSIve but curable mostly child hood lymphoma |
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Term
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Definition
| starry sky pattern, no follicles. Look at bone marrow aspirate in harrison lecture- vaculoes in plasma, |
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Term
| Diffuse LargeB cell lymphoma |
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Definition
| aggressive but curable- elderly and childhood , male preponderance. Immunodeficiency associated with HIV, and hten infeciton with EBV. Also primary efffusion lymphoma- tumor cells infected by kshv/hhv-8 |
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Term
|
Definition
| Cd19, 20 positive only. If also cd 10 positive then tranformed from follicular lymphoma. BCL-6 rearrangement. |
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Term
|
Definition
| diffuse large cells with centroblasts. Look at harrisons and mehtasslide |
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Term
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Definition
| Maltoma, majority in spleen and mALT, but can arise anywhere (salivary glands, stomach, orbits , thymus ). Risk factors: H. pylori and HCV. |
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Term
| Marginal b cell lymphom markers |
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Definition
| cd5-, cd10- , multiple chromosomal tranaslocations resulting in Api2-MAlt1) |
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Term
| Marginal b cell morphology |
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Definition
| prolfi of small lymphocytes (fried eggaappearance). |
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Term
| marginal b cell lymphoma: treatment/prognosis |
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Definition
| irradicate hy. Pyrlori. , better than SLL. |
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Term
| Hairy cell clinical manifestations. |
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Definition
| pancyotpenia, but NO lymphadeonpathy. , massive splenomegaly , and monocytopenia. Spleen with red uplupl invovlement and red blodo cell clakkes. |
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Term
|
Definition
| cd22,cd11c/cd19/fmc7/cd103, cd25 and DBA.44 |
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Term
|
Definition
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Term
|
Definition
| rare, middle aged to elderly adults. |
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Term
|
Definition
| visible via trapp stain, lymphocytes with hairlike projections. BM is completley fibrotic. |
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Term
|
Definition
| termianlly differentiated B cells, Ig screting plasma cells -> serum contains monoclonal M protein. |
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Term
| Multiple myeloma clinical features |
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Definition
| tumorous masses of plasma cells throughout skeletal system. Monoclonal gammopathy with m protein. Bence jones proteinurea. Multiple lytic lesions of bone. Solitary plasmocytoma- for soiltary massesi n bone and soft tissue. |
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Term
|
Definition
| plasma cells produce cytokines, most importantly IL-6 (also important for own survival, poor prognostic indicator). , which are osteoclast activators. |
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Term
| multiple myeloa histology |
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Definition
| eccentric nuclei , some palsma cells binucleate with peripheral halo. |
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Term
| Waltdenstorms macrogloulinema |
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Definition
| high levles of monclonal IGM, causesh ypervisocity syndrome. |
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Term
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Definition
| hetergeonous group of neoplasms resemblignmature T -cells. Present with severe itching , fever weight loss, eosonophilia. Lymphadenopathy |
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Term
| peripheral t cell lymphoma markers/ histology |
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Definition
| All t cell markers except cd7. |
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Term
| peripheral t cell lymphoma prognosis/age range. |
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Definition
| children, young adults, good prognosis. |
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Term
| Adult T cell lymphoma/luekemia clinical symptoms |
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Definition
| neoplasm of cd4 cell. Skn lesions , hypercalcemia, Cns and spine, extremley aggrsive bad prognosis |
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Term
| etiology of adutlt t cell |
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Definition
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Term
| HL: nodular lymphocyte predomiannat. |
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Definition
| young males , cervical or axialary lymphadenopathy, popcorn cells (variatnof r-s) best survival |
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Term
| hl nodular lymphocyte markers |
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Definition
| positive for cd20, but negative for 14,30, ane ebv. |
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Term
| classic hodgkins lymphocyte rich |
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Definition
| older individuals, male more htan female. Many mononcuelar and clssic r-s cells , background of t lymphocytes. |
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Term
| classic hodgkins lymphcite rich markers |
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Definition
| cd15,cd30, and ebv positive. |
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Term
| classic hodgkins: nodular sclerosis |
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Definition
| Mediastinal mass, young females. Nodule , bands of collagen. type of RS cell: lacunar cells |
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Term
| classic hodgins (nodular sclerosis) histology/markers |
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Definition
| cd15, cd30 postiitve, but negative for ebv. |
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Term
| mixed cellularity, classic hodgkins lymphoma |
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Definition
| M>F, biphasic, young adults and after 50. classic r-s cells. - in bckground of eosinohpils, plasma cells ,lymphocytes,histocytes. |
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Term
| lymphocyte depleted classic hodgkisn lymphoma |
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Definition
| elderly and hiv positivei ndividuals: lack of backgroudn cells. Classic R-s Cells. most aggresive/poorest survival. |
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Term
| lymphocyte depleted classic hodgkins lymphoma marker |
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Definition
| cd15,cd30, and ebv positive |
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Term
|
Definition
| predictable pattern of spread: goes to contigious lymph nodes-> spleen-> liver->extranodal involvement and marrow disease. Staging: stage 1, one lymph node, stage 2: two lymph nodes or more on same side of diaphragm stage 3: more than one lymph node on opposite sides of diaphragm, stage iv: organ infiltration. may include B SYPTOMS: weightloss of more than ten percent, recurrent fevers more than 101 F. |
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Term
|
Definition
| rat of cellular proliferation is determiendby the specific mutations. A lymphoma driven by a mutation in maturation and prolaiferation will grow quickly and may kill faster, whereas one where apoptosis is blocked will grow a lot slower. |
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Term
|
Definition
| get a biopsy, stage the patient (to figure out progrssion of disease), and evlauate vital organ function (especially before giving treatment to make sure that you dotn give the m drug that is supertoxic to something that is already impaired!!, |
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Term
| extra nodal t nk cell lymphoma |
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Definition
| intestinal tract lymphoma seen with celiac disease |
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Term
|
Definition
| lymphodenopathy and palpable msses, pancytopenia due to bone marrow infiltration . Can infiltrate CNS (accumualting around nere roots) . Rashes/skin infiltration. Liver infiltration, acute renal fialure- duet o ureter infiltration. Hypercalcemia fracturesd ude ot bone infitlration (hypercalcemia causes confusion, consitpation, hypercalcemia, and renal failure (along with hyperuricemia) |
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|
Term
| LDH levels with regard to lymphoams |
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Definition
| leaks out of lymphocytes, bad prognosis marker. |
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|
Term
| side effects of chemotherapy |
|
Definition
| pulmonary fiborsis, mucositis, cardiotoxicity, pulmonary fiborsis, lcoal reaciton ,renal failure, myelosupression,sterility , DVT |
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Term
|
Definition
| combination chemotherapy teatmetn. Cyclophosphamide, hydroperoxydanroribbin, oncovin, prednisone. |
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Term
|
Definition
| for stage 1a, radiation therapy, for everything chemotherapy using ABD treatmetn (adriamycing, bleomycin, vinblastine,decarbazine) |
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Term
|
Definition
| mostly in immunocompromosied patients, due to aids epidemic, also caused by EBV. |
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Term
| CNS lymphoma clinical features |
|
Definition
| never spreads systematically, cns deficits includign cord compression. Leptomeningeal lymphomatosis- manycarnial nerves damaged |
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Term
| cutaneous T cell lymphoma intro and lcinical features |
|
Definition
| comprised cd4plus lymphocytes. Difuse erythroderma (skin redness) Also see pathcesor plaques (look at harrison slide). Rlatively indolent |
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Term
|
Definition
| cutaneous t cell lymphoma limited to cutaneous involvement |
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Term
|
Definition
| cutaneous t cell lymphpoma that has spreadt o blood. |
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|
Term
| cutaneous t cell lymphoma histology |
|
Definition
| subdermal patches (look at harrison slide) |
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Term
|
Definition
| look at mehta slide: malignatn mantle cels are acutally cells that should have been germina lcenter cells |
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Term
| anaplstic large cell lymphoma prognosiss and marker and histology |
|
Definition
aggressive but very curable. Alk protoncogene over exrepsion translocation of (2,5). Cd30 cell surfacemarker
horshoe nucleus |
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|
Term
| precursor t cell lymphoma |
|
Definition
| involvement of anterior mediastinal/cervial nodes |
|
|
Term
| mixed cellularity markers |
|
Definition
| cd15plus , cd30plus, ebvlpus |
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