Term
| X-linked immunoprolif disease |
|
Definition
|
|
Term
|
Definition
1. Burkits 8:14 - myc transcription f.
2. follicular 14:18 - bcl2 - apoptosis
3. mantle cell 11:18 - bcl1 phosphorlation rb
4. 1:14, 14-18 = MALT with NFKB
5. 2:5 = anaplastic large cell - ALK (increased cell surface receptor) |
|
|
Term
|
Definition
Hodkins: reed sternburg, 20-40 bimodal, mediastinal mass, bm uncommon, decreased cellular immunity
usually B
nonH: 50-70 monoclonal
higher stage
BM involvement
humal loss in CLL
9/10 = B |
|
|
Term
| Lymphocyte predominant hodkins disease |
|
Definition
2% cases, highest survival and best prognosis
POPCORN CELLS +/- Reed sternburg
CD 45/CD20
Cervical involvement common
B cell predominant |
|
|
Term
|
Definition
| CD 15/30 with reedsternburg and very high survival. |
|
|
Term
|
Definition
1. female predominant with good prognosis and decent survival
15/30 +/- 20 CD.
Lacunar cells, bands fibrosis, mediastinal involvment common |
|
|
Term
| Mixxed cellularity classic HL |
|
Definition
15/30 hodkins with RS cells + eosinophilia + plasma cells and focal necrosis.
guarded prognosis |
|
|
Term
|
Definition
Often T cell lymphoma with huge amount of RS cells (found older patient)
poor prognosis |
|
|
Term
| NH lymphoma adult vs. child |
|
Definition
adult: follicular, CLL, Mantle
child: burkitt, ALL, Anaplastic large |
|
|
Term
|
Definition
| CD 20+ mab for B cell lymphomas |
|
|
Term
|
Definition
SLL: CD 20/5/23
follicular: 20/10 +/- 23
Mantle = 20/5 only
Malt= 20 only |
|
|
Term
|
Definition
same as cll (older adults with richter transformation to large b cell)
CD 20/5/23 |
|
|
Term
|
Definition
t(14:18), BCL 2 in germinal center!
pure B with CD10/20/ +/- 23 |
|
|
Term
|
Definition
|
|
Term
|
Definition
t(11:14) CD 5/20 adult high stage lymphoma that may present with splenic or gi involvement and resemble others
BCL-1 = cyclin D1 |
|
|
Term
|
Definition
t(11:18) Indolent adult lymphoma associated with H-pylori
CD 20 only
contains plasma cells |
|
|
Term
|
Definition
aggressive B cell lymphoma
CD 19/20 +/- 10
(10 BCL6 = more favorable) |
|
|
Term
| Periphral T cell lymphoma |
|
Definition
| Very aggressive, Mature T phenotype |
|
|
Term
| Angioimmunoblastic T lymphoma |
|
Definition
Lymph + Liver + pruitis lymphoma with pruitis/rash and poor prognosis due to gammopathy
increase in HEV w/ EBV B
CD 3/4/10!!! |
|
|
Term
| Extranodal NK cell lymphoma |
|
Definition
Lethal midline granuloma
asia/mid america with ulcerating masses
CD56 vasculitis |
|
|
Term
|
Definition
T cell lymphoma of skin
cerebreform nucli
pautri microabcesses
CD4+
Sezry = blood involvment skin |
|
|
Term
|
Definition
Very Aggressive childhood lymphoma
t*8:14) c myc
lots of mitosis and starry ski
EBV
CD 20/10 |
|
|
Term
|
Definition
related to all
aggressive T/B cell lymphoma children
mediastinal cd3 and Tdt markers |
|
|
Term
| anaplastic large cell lymphoma |
|
Definition
Aggressive T (curable)
extranodal which is CD30+ ALK
t(2;5) |
|
|
Term
|
Definition
| monoclonal gammopathy of undetermined signifigance (plasma)--> no bone involvment |
|
|
Term
|
Definition
bone destruction, decreased humoral immunity, INcreased M protein from plasma
may cause renal failure from amlydosis
meausre b2 microglobin for prognosis |
|
|
Term
|
Definition
plasma cell only
CRAB presentation (calcium, renal, anemia,bone)
may be smoldering
no organ impariment and elevated M protien 10% clonal plasma cells |
|
|
Term
|
Definition
AL - mm
AA - RA/chrones (bad)
B = Alzheimrs
Ab2M = hemo
ATTR = familial cardiac |
|
|
