Pulmonary: root of lungs

Inguinal: groin

Mesenteric: along intestinal vessels

Popliteal: behind knee

Axillary: armpits

Aortic: along aorta

Cervical: neck

Cubital:elbow

• Bring lymph to the lymph nodes.
• Has valves to stop backward flow
• More numerous than Efferent vessels

• very rich in B-cells
• Lymphoblasts in Germline center
• Memory cells in Mantle zone

• T cells. Known as T dependent region.
• Found between cortex and medulla

Cords: contain Memory Cells and Plasma cells.

Sinuses: space between cords. Contain mesh of reticular cells and fibers, macrophages, and follicular dendrites. Slows and filters lymph.

1. If it is presented with a large amount of antigens, the Germinal Centers of the nodules would enlarge due to increased lymphoblast production. In this case it would hurt if touched.
2. If it is not painful than it is a suggestion of cancer.

Filters Lymph

• Adds: Immunoglobins, Lymphocytes, Plasma Cells.
• Removes: Antigens, debris, lymphocytes, bacteria, tumor cells.

• Post capillary venules in the paracortical zone of lymph nodes.
• Lined with cuboidal cells
• Initiates diapedesis. T cells leave blood and start path towards infected area.

1. Rolling: Selectins on lymphocyte microvilli form and break weak attachments, slowing lymphocytes.
2. Tethering: Binding of selectins to receptors strengthens as lymphocytes slow further.
3. Activation: Selectin-receptor interactions trigger chemokine release.
4. Stronger Adhesion: Chemokines initiate stronger adhesion.
5. Transmural Emigration: Lymphocytes squeeze between endothelial cells and exit vessel. (They leave blood and enter lymph node)

Is used as part of a physical examination in which an object is felt (usually with the hands of a healthcare practitioner) to determine its size, shape, firmness, or location

An enlargement of the spleen, which usually lies in the left upper quadrant (LUQ) of the human abdomen.

• Filters blood for antigens
• RBC reserve
• Removes aging RBC's from circulation.

Aorta→ Splenic A→ Trabecular A→ Central A→ Penicullar Arteriole→ Sheathed Arteriole→ Red Pulp Sinuses→ Red Pulp Veins→ Trabecular V→ Splenic V→ Portal V

Blood empties blindly from Sheathed Arteriole into red pulp cords and perculate into Red Pulp Sinuses.

• Red Pulp(Billroth's) Cords: irregular recticular connective tissue. Plasma and Memory cells.
• Splenic Sinuses: slightly different than capillaries.

Periarterial Lymphatic Sheaths (PALS): Surrounds Central Arteries. T cell rich.

Peripheral White Pulp (PWP): Nodules. B cell rich

Dumps RBC's into blood and provides Oxygen

• Palatine: Lateral walls of oral pharynx.
• Pharyngeal(one): posterior of nasopharynx. Above level of soft palet. Also called Adenoid.
• Lingual: back third of the tongue. (floor of the pharynx)

Nonkeratinized Stratified Squamous