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loyola
oncogenes, tumor suppressor genes, and tumor markers
26
Medical
Professional
05/20/2006
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Term
abl
 Definition
CML
Term
c-myc
 Definition
Burkitt's lymphoma
Term
bcl-2
 Definition
follicular and undifferentiated lymphomas (inhibits apoptosis)
Term
erb-B2
 Definition
breast, ovarian, and gastric carcinomas
Term
ras
 Definition
colon CA
Term
l-myc
 Definition
lung tumor (small cell carcinoma)
Term
N-myc
 Definition
neuroblastoma
Term
ret
 Definition
MEN II and III
Term
Rb (13q)
 Definition
Retinoblastoma, osteosarcoma
Term
BRCA1 and 2 (17q,13q)
 Definition
breast and ovarian carcinoma
Term
p53 (17p)
 Definition
most human cancers, Li-flaumeni syndrome
Term
APC (5q)
 Definition
colorectal CA
Term
WT1 (11q)
 Definition
Wilms tumor
Term
NF1 (17q)
 Definition
Neurofibromatosis I
Term
NF2 (22q)
 Definition
Neurofibromatosis II
Term
DPC (18q)
 Definition
pancreatic cancer
Term
DCC (18q)
 Definition
colon cancer, stomach ca
Term
PSA
 Definition
prostate-specfic antigen, marker for prostate Ca, used as a screening test
Term
CEA
 Definition
carcinoembryonic antigen (non-specific but produced by 70% of colorectal and pancreatic CA, and also gastric and breast CA)
Term
Alpha-fetoprotein
 Definition
nlly made by fetus; found in hepatocellular CA and yolk sac tumors of the testes (nonseminomatous germ cell tumors)
Term
B-hCG
 Definition
Hyatidaform moles, choriocarcinomas and gestational trophoblastic tumors
Term
CA-125
 Definition
ovarian, malignant epithelia tumors
Term
S-100
 Definition
melanoma, neural tumors, astrocytomas
Term
AP
 Definition
mets to bone (osteoBLASTIC), obtructive biliary dz, paget's dz of bone
Term
Bombesin
 Definition
neuroblastoma, lung and gastric tumors
Term
TRAP
 Definition
Hairy cell leukemia (B cell neoplasm)
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