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Lower GI pharmacolgy
very basic info on lower GI drugs
24
Dentistry
Professional
09/19/2012

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Cards

Term
Benadryl
Definition
Antihistamine - antiemetic
Term
dramamine (Dimenhydrinate)
Definition
antihistamine - antiemetic
Term
bonine (Meclizine)
Definition
antihistamine - antiemetic
Term
metoclopramide
Definition
central D2 and 5-HT antagonist - increase LES tone and decrease pyloric sphincter tone.  Prevent vomiting.  Uncontrolled movement as side effect in long term use
Term
Domperidine
Definition
D2 antagonist - increast LES tone, decrease pyloric valve tone.  Prevent vomiting.  Does not cross BBB to large degree, little central nervous effects (compared to metoclopramide)
Term
Ondansitron
Definition
5-HT3 antagonist (peripheral vagal afferents) - antoemitic
Term
Syrup of Ipecac
Definition
Induce vomiting by triggering medullary chemoreceptors
Term
Apomorphine
Definition
Trigger vomiting - CNS depression possible - rescue with Naloxone
Term
Kaopectate
Definition
Anti-diarrheal - absorbs fluids
Term
Codiene/Morphine etc
Definition
Anti-diarrheal - decrease GI motility by increasing GI smooth muscle tone
Term
Loperamide
Definition
Imodium - decrease GI motility - anti-diarrheal
Term
Diphenoxylate
Definition
anti-diarrheal - decrease gastic motility. Potentiates barbituates, mildly habit forming
Term
Cimetidine
Definition
H2 blocker - can prevent diarrhea due to acid hypersecretion
Term
Cholestryamine
Definition
treatment of diarrhea due to bile salt induced enteropathy (removal of ilium - no bile salts reabsorbed) - disables cathartic effect of bile salts
Term
Octreotide
Definition
Synthetic analog of Somatostatin
Term
Epsom Salt
Definition
Stimulate bowel motility
Term
Castor Oil
Definition
releases riconoleic acid - irritates bowel and increases fluid secretion - makes you shit
Term
Phenopthalein
Definition
Cathartic laxative - enterohepatic circulation - may be carcinogenic
Term
Liquid Paraffin
Definition
stool softener - may affect drug absorption
Term
Docusate
Definition
detergent laxative, may affect drug absorption
Term
methyl cellulose, Bran
Definition
Increase bulk of stools, regularity
Term
prednisone
Definition
synthetic corticosteroid - tx for IBD
Term
Sulfasalzine
Definition
salicylic acid and sulfapyridine dimer - cleaved by bacteria - tx for IBD  (aspirin for the lower GI - antinflammatory) - sulfapyridine is toxicrm in the long term
Term
Olsalazine
Definition
salicylic acid pro-drug cleaved by bacteria in lower GI - no toxicity like sulfasalazine
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