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LECTURE 2
ENDOCRINOLOGY
134
Medical
Professional
08/14/2013

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Term
WHAT IS NECROSIS?
Definition
NON-PROGRAMMED CELL DEATH
NUCLEUS DESTROYED FIRST
Term
WHAT IS APOPTOSIS?
Definition
PROGRAMMED CELL DEATH
NO INFLAMMATION
Term
WHAT IS PYKNOSIS?
Definition
NUCLEUS TURNS INTO BLOBS
"BLOBS"
Term
WHAT IS KARYORRHEXIS?
Definition
NUCLEUS FRAGMENTS
Term
WHAT IS KARYOLYSIS?
Definition
NUCLEUS DISSOLVES
Term
WHAT IS SOMATOTROPE?
Definition
GH
Term
WHAT IS A GONADOTROPE?
Definition
LH, FSH
Term
WHAT IS A THYROTROPE?
Definition
TSH
Term
WHAT IS A CORTICOTROPE?
Definition
ACTH
Term
WHAT IS A LACTOTROPE?
Definition
PROLACTIN
Term
WHAT RECEPTORS DO PROTEIN HORMONES USE?
Definition
CELL MEMBRANE RECEPTORS
Term
WHAT RECEPTORS DO STEROID HORMONES USE?
Definition
NUCLEAR MEMBRANE RECPTORS
Term
WHAT ARE STEROID HORMOES?
Definition
"PET CAD"
PROGESTERONE
E2
TESTOSTERONE
CORTISOL
ALDOSTERONE
VITAMIN D*
TSH
*ACTS LIKE A STEROID
Term
WHAT DOES ENDOCRINE MEAN?
Definition
SECRETED INTO BLOOD
Term
WHAT DOES EXOCRINE MEAN?
Definition
SECRETED INTO NON-BLOOD
Term
WHAT IS AUTOCRINE?
Definition
WORKS ON ITSELF
Term
WHAT IS PARACRINE?
Definition
WORKS ON IT NEIGHBOUR
Term
WHAT IS MEROCRINE?
Definition
CELL IS MAINTAINED (EXOCYTOSIS)
Term
WHAT IS APOCRINE?
Definition
APEX OF THE CELL IS SECRETED
Term
WHAT IS HOLOCRINE?
Definition
WHOLE CELL IS SECRETED
Term
WHAT ORGANS DO NOT REQUIRE INSULIN?
Definition
"BRICKLE"
BRAIN
RBC
INTESTINE
CARDIAC/CORNEA
KIDNEY
LIVER
EXERCISING MUSCLE
Term
WHAT DOES GNRH DO?
Definition
STIMULATES LH, FSH
Term
WHAT DOES GRH DO?
Definition
STIMULATES GH
Term
WHAT DOES CRH DO?
Definition
STIMULATES ACTH
Term
WHAT DOES TRH DO?
Definition
STIMULATES TSH
Term
WHAT DOES PRH DO?
Definition
STIMULTES PRL
Term
WHAT DOES DA DO?
Definition
INHIBITS PRL
Term
WHAT DOES SS (SOMATOSATIN)DO?
Definition
INHIBIT GH
Term
WHAT DOES ADH DO?
Definition
CONSERVES WATER, VASOCONSTRICS
Term
WHAT DOES OXYTOCIN DO?
Definition
MILK LET DOWN
BABY LET DOWN
Term
WHAT DOES GH DO?
Definition
IGF-1 RELEASE FROM LIVER
Term
WHAT DOES TSH DO?
Definition
T3, T4 RELEASE FROM THYROID
Term
WHAT DOES LH DO?
Definition
TESTOSTERONE RELEASE FROM TESTES
E2 AND PROGESTERONE RELEASE FROM OVARY
Term
WHAT DOES FSH DO?
Definition
SPERM OR EGG GROWTH
Term
WHAT DOES PRL DO?
Definition
MILK PRODUCTION
Term
WHAT DOES ACTH DO?
Definition
CORTISOL RELEASE FROM ADRENAL GLAND
Term
WHAT DOES MSH DO?
Definition
SKIN PIGMENTATION
Term
WHAT ARE THE STRESS HORMONES ?
TIME FRAME?
Definition
EPINEPHRINE - IMMEDIATE
GLUCAGON - 20 MINUTES
INSULIN - 30 MINUTES
ADH- 30 MINUTES
CORTISOL- 2-4 HOURS
GH - 24 HOURS
Term
WHAT DOES ADH DO?
Definition
CONCENTRATES URINE
Term
WHAT IS DIABETES INSIPIDUS?
Definition
TOO LITTLE ADH (URINATES A LOT)
Term
WHAT IS CENTRAL DI?
Definition
BRAIN NOT MAKING ADH
Term
WHAT IS NEPHROGENIC DI?
Definition
BLOCK OF V2 AQUAPORIN RECEPTORS
CAN BE CAUSED BY LITHIUM, DEMECLOCYCLIN
Term
WHAT DOES THE WATER DEPRIVATION TEST TELL YOU?
Definition
WATER DEPRIVATION ->DI FAILS TO CONCENTRATE URINE
Term
WHAT DOES GIVING DDAVP TELL YOU?
Definition
DDAVP->CENTRAL DI CONCENTRATES >25%
Term
WHAT IS SIADH?
Definition
TOO MUCH ADH =>EXPANDS PLASMA VOLUME
Term
WHAT IS THE DIFFERENCE BETWEEN DI AND SIADH?
Definition
DI HAS NO ADH - HAS DILUTE URINE
SIADH HAS TOO MUCH ADH - HAS CONCENTRATED URINE
Term
WHAT IS PSYCHOGENIC POLYDYPSIA?
Definition
PATHOLOGICAL WATER DRINKING => LOW PLASMA OSMOLARITY
Term
WHAT DOES ALDOSTERONE DO?
Definition
REABSORBS NA AND 3 WATERS
SECRETES H+ (VIA H/K PUMP)
Term
WHAT IS NEUROBLASTOMA?
Definition
ADRENAL MEDULLA TUMOUR IN KIDS
DANCING EYES/FEET
SECRETES CATECHOLAMINES
Term
WHAT IS PHEOCHROMOCYTOMA?
Definition
ADRENAL MEDULLA TUMOUR IN ADULTS
Term
WHAT DOES THE ZONA G. MAKE?
Definition
ALDOSTERONE "SALT" HORMONE
Term
WHAT DOES THE ZONA F. MAKE?
Definition
CORTISOL "SUGAR" HORMONE
Term
WHAT DOES THE ZONA R. MAKE?
Definition
ANDROGENS "SEX" HORMONES
Term
WHAT IS CONN'S SYNDROME?
Definition
HIGH ALDOSTERONE (TUMOUR - PRIMARY)
Term
WHAT DOES ANP DO?
Definition
INHIBITS ALDOSTERONE
DILATES RENAL ARTERY (AFFRENT ARTERIOLE)
Term
WHAT DOES CALCITONIN DO?
Definition
INHIBITS OSTEOCLASTS => LOW SERUM CA
Term
WHAT IS MENI?
Definition
"WERMER'S" 3 P'S
PANCREAS
PITUITARY
PARATHYROID
Term
WHAT IS MENII (IIA)?
Definition
SIPPLE'S
PHEOCHROMOCYTOMA
MEDULLARY CARCINOMA OF THE THYROID
+/- PARATHYROID
Term
WHAT IS MENIII (IIB)?
Definition
PHEOCHROMOCYTOMA
MEDULLARY CARCINOMA OF THE THYROID
+/- PARATHYROID
Term
WHAT DOES CCK DO?
Definition
GALLBLADDER CONTRACTION
Term
WHAT DOES CORTISOL DO?
Definition
GLUCONEOGENESIS BY PROTEOLYSIS => THIN SKIN
Term
WHAT IS ADDISON'S DISEASE?
Definition
AUTOIMMUNE DESTRUCTION OF ADRENAL CORTEX
Term
WHAT IS WATERHOUSE FRIDERICHSEN?
Definition
ADRENAL HAEMORRHAGE
Term
WHAT IS CUSHING'S SYNDROME?
Definition
HIGH CORTISOL
PIT TUMOUR, ADRENAL TUMOUR, OR SMALL CELL CA OF LUNG
Term
WHAT IS NELSON'S SYNDROME?
Definition
HYPERPIGMENTATION AFTER ADRENALECTOMY
Term
IF THE LOW DOSE DEXAMETHASONE TEST SUPPRESSES WHAT DOES THAT TELL YOU?
Definition
DEPRESSION, OBESE, OR NORMAL VARIANT
Term
IF THE LOW DOSE DEXAMETHASONE TEST DOES NOT SUPPRESS WHAT DOES THAT TELL YOU?
Definition
CUSHING'S, DO HIGH DOSE TEST
Term
IF THE HIGH DOSE DEXAMETHASONE TEST SUPPRESSES WHAT DOES THAT TELL YOU?
Definition
ITS A PITUITARY TUMOUR =>ACTH
Term
IF A HIGH DOSE DEXAMETHASONE TEST DOES NOT SUPPRESS , WHAT DOES THAT TELL YOU?
Definition
TEST ACTH
LOW ACTH : ADRENAL ADENOMA => CORTISOL
HIGH ACTH : SMALL CELL LUNG CA =>ACTH
Term
WHAT ARE THE SURVIVAL HORMONES?
Definition
CORTISOL : PERMISSIVE UNDER STRESS
TSH: PERMISSIVE UNDER NORMAL
Term
WHAT DOES EPINEPHRINE DO?
Definition
GLUCONEOGENESIS
GLYCOGENOLYSIS
Term
WHAT DOES ERYTHROPOIETIN DO?
Definition
MAKES RBC
Term
WHAT DOES GASTRIN DO?
Definition
STIMULATES PARIETAL CELLS => IF, H+
Term
WHAT DOES GH DO?
Definition
GROWTH
SEND SOMATOMEDINS (IGF1) TO GROWTH PLATE
GLUCONEOGENESIS BY PROTEOLYSIS
Term
WHAT IS ACHONDROPLASIA (LEON DWARF)?
Definition
ABNORMAL FGF RECEPTORS IN THE EXTREMITIES
Term
WHAT IS A MIDGET?
Definition
DECREASED SOMATOMEDIN RECEPTOR SENSITIVITY
Term
WHAT IS ACROMEGALY?
Definition
ADULT BONES STRETCH "MY HAT DOESN'T FIT"
COARSE FACIAL FEATURES
LARGE FURROWED TONGUE
DEEP HUSKY VOICE
JAW PROTRUSION
INCREASED IGFI D/T GH TUMOUR
Term
WHAT IS GIGANTISM?
Definition
CHILDHOOD ACROMEGALY
Term
WHAT DOES GIP DO?
Definition
INCREASE INSULIN ACTION => POST-PRANDIAL HYPOGLYCEMIA
Term
WHAT DOES GLUCAGON DO?
Definition
GLUCONEOGENESIS
GLYCOGENOLYSIS
LIPOLYSIS
KETOGENESIS
Term
WHAT DOES INSULIN DO?
Definition
PUSHES GLUCOSE INTO CELLS AND K+ FOLLOWS
Term
WHAT IS TYPE I DM?
Definition
ANTI-ISLET CELL AB
COXSACKIE B
LOW INSULIN
DKA
POLYURIA
POLYDYPSIA
Term
WHAT IS TYPE II DM?
Definition
INSULIN RECEPTOR INSENSITIVITY
HIGH INSULIN
HONK COMA
ACANTHOSIS NIGRICANS
Term
HOW DOES DKA PRESENT?
Definition
KUSSMAUL RESPIRATION
FRUITY BREATH
ALTERED MENTAL STATUS
Term
WHAT IS THE DAWN PHENOMENON?
Definition
AM HYPERGLYCEMIA 2NDARY TO GH
Term
WHAT IS THE SOMOGY EFFECT?
Definition
AM HYPERGLYCEMIA 2NDARY TO EVENING HYPOGLYCEMIA
Term
WHAT IS FACTITIOUS HYPOGLYCEMIA?
Definition
INJECTED INSULIN (HIGH INSULIN, LOW C-PEPTIDE)
Term
WHAT IS AN INSULINOMA?
Definition
INSULIN SECRETING TUMOUR (HIGH INSULIN, LOW C-PEPTIDE)
Term
WHAT IS METABOLIC SYNDROME X?
Definition
"PRE-DM"
HTN
DYSLIPIDEMIA
HYPERISULINEMIA
ACANTHOSIS NIGRICANS
Term
WHAT ARE FOOT ULCER RISK FACTORS?
Definition
DM/GLYCEMIC CONTROL
MALE
SMOKING
BONY DEFORMITIES
PREVIOUS ULCERS
Term
WHAT CONDITIONS CAUSE WEIGHT GAIN?
Definition
OBESITY
HYPOTHYROIDISM
DEPRESSION
CUSHING'S
ANASARCA
Term
WHAT DOES MOTILIN DO?
Definition
STIMULATES SEGMENTATION (1 PERISTALSIS, MMC)
Term
WHAT DOES PTH DO?
Definition
STIMULATES OSTEOBLASTS TO TURN ON OSTEOCLASTS
Term
WHAT DOES VITAMIN D DO?
Definition
HELPS CALCIUM RE-ABSORPTION FROM THE GI TRACT
Term
WHAT DO PARATHYROID CHIEF CELLS SECRETE?
Definition
PTH
Term
WHAT DO STOMACH CHIEF CELLS SECRETE?
Definition
PEPSIN
Term
WHAT IS THE DIFFERENCE BETWEEN NOREPINEPHRINE AND EPINEPHRINE?
Definition
NE=NEUROTRANSMITTER
EPI= HORMONE
Term
WHAT IS PRIMARY HYPERPARATHYROIDISM?
Definition
PARATHYROID ADENOMA
Term
WHAT IS SECONDARY HYPERPARATHYROIDISM?
Definition
RENAL FAILUR
Term
WHAT IS FAMILIAL HYPOCALCIURIA HYPERCALCEMIA?
Definition
DECREASED CALCIUM EXCRETION
Term
WHAT IF BOTH SERUM CA AND PO4 DECREASE?
Definition
VITAMIN D DEFICIENCY
Term
WHAT IF CA AND PO4 CHANGE IN OPPOSITE DIRECTIONS?
Definition
SECONDARY PROBLEM (NOT PRIMARY)
Term
WHAT IS THE MCC OF PRIMARY HYPOPARATHYROIDISM?
Definition
THYROIDECTOMY
Term
WHAT IS PSEUDOHYPOPARATHYROIDISM?
Definition
BAD KIDNEY PTH RECEPTOR
DECREASED URINARY CAMP
Term
WHAT IS PSEUDOPSEUDOHYPOPARATHYROIDISM?
Definition
G PROTEIN DEFECT
NO CA PROBLEM
Term
WHAT IS HUNGRY BONE SYNDROME?
Definition
REMOVE PTH =>BONE SUCKS IN CA
Term
WHAT DOES SECRETIN DO?
Definition
SECRETION OF BICARB
INHIBITS GASTRIN
TIGHTEN PYLORIC SPHINCTER
Term
WHAT DOES SOMATOSTATIN DO?
Definition
INHIBITS SECRETIN, MOTILIN, CCK
Term
WHAT DO T3 AND T4 DO?
Definition
GROWTH, DIFFERENTIATION
Term
WHAT DISEASE HAS EXOPHTHAMLMOS?
Definition
GRAVES
Term
WHAT DISEASE HAS ENDOPHTHALMOS?
Definition
HORNER'S
Term
GRAVE'S
Definition
EXOPHTHALMOS
PRE-TIBIAL MYXEDEMA
TSH RECEPTOR ANTIBODIES
Term
DEQUERVAIN DISEASE
Definition
VIRAL (SELF LIMITING)
Term
SILENT THYROIDITIS
Definition
POST-PARTUM
Term
PLUMMER'S
Definition
BENIGN ADENOMA
>50 Y/O
Term
JOB-BASEDOW
Definition
TRANSIENT HYPERTHYROIDISM DUE TO HIGH IODINE
Term
HASHIMOTO'S THYROIDITIS
Definition
ANTIMICROSOMIAL ANTIBODIESB=TPO ANTIBODIES
Term
REIDEL'S STRUMA
Definition
WOODY
Term
CRETINISM
Definition
HYPOTHYROID MUM AND BABY
Term
EUTHYROID SICK SYNDROME
Definition
LOW T3 SYNDROME AFTER A SICKNESS
Term
WOLFF-CHAIKOFF
Definition
TRANSIENT HYPOTHYROIDISM
Term
WHAT IS PLUMMER'S SYNDROME?
Definition
HYPERTHYROID ADENOMA
Term
PLUMMER-VINSON SYNDROME?
Definition
ESOPHAGEAL WEBS
Term
WHAT DOES TETOSTERONE DO?
Definition
MAKE EXTERNAL MALE GENITALIA
Term
WHAT DOES MULLERIAN INHIBITING FACTOR DOES?
Definition
MAKES INTERNAL MALE GENITALIA - ON Y CHROMOSOME
Term
WHAT DOES TPO AND THYMOSIN DO?
Definition
HELP T CELLS MATURE
Term
WHAT DOES VIP DO?
Definition
INHIBITS SECRETIN, MOTILIN, CCK
OPENS SPHINCTER
Term
HOW DOES A VIPOMA PRESENT?
Definition
WATERY DIARRHOEA
Term
HOW DOES A SSOMA PREESENT?
Definition
COSTIPATION
Term
WHAT ARE HORMONES WITH DISULFIDE BONDS?
Definition
PRL
INSULIN
GH
INHIBIN
Term
WHAT HORMONES HAVE THE SAME ALPHA SUBUNITS?
Definition
LH,FSH
TSH
Term
WHAT HORMONES ARE PRODUCED BY ACIDOPHILS?
Definition
GH
PRL
Term
WHAT HORMONES ARE PRODUCED BY BASOPHILS?
Definition
FSH
LH
ACTH
TSH
Term
WHAT HORMONES ARE RELEASED FROM THE POSTERIOR PITUITARY?
Definition
ADH (SUPRA-OPTIC NUCLEUS)
OXYTOCIN (PARAVENTRICULAR NUCLEUS)
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