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Local & General Anaesthetics
PHAR450
17
Pharmacology
Undergraduate 4
04/01/2014

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Cards

Term
Cocaine
Definition
First local anesthetic used clinically, introduced by Freud
Amino ester
Term
Procaine (Novocaine)
Definition
Local anesthetic
Amino ester
Term
Tetracaine
Definition
Local anesthetic
Amino ester
Term
Lidocaine
Definition
Local anesthetic
Amino amide
Rapid onset and medium duration of action
Term
Bupivacaine
Definition
Local anesthetic
Amino amide
Term
Ropivacaine
Definition
Local anesthetic
Amino amide
Term
Mepivacaine
Definition
Local anesthetic
Amino amide
Term
Nitrous Oxide (N2O)
Definition
Non-volatile, inhaled anesthetic
Low potency (MAC 104%) thus incomplete
Rapid onset and offset
Prominent analgesic effects
Minimal hypotension and respiratory depression
Dilation of air-filled spaces
Associated with nausea
Term
Haloethane
Definition
Volatile, inhaled anesthetic
High potency (MAC 0.74%)
Slow induction and emergence
Hypotension via myocardial depression
Depressed ventilation
Causes nausea and vomiting
Can lead to liver toxicity (haloethane hepatitis)
Term
Isoflurane
Definition
Volatile, inhaled anesthetic
MAC 1.15%
Slow emergence, no induction
Hypotension via vasodilation
Depressed ventilation
Causes nausea and vomiting
Term
Sevoflurane
Definition
Volatile, inhaled anesthetic
MAC 2.01%
Rapid induction and emergence
Hypotension via vasodilation
Depressed ventilation
Causes nausea and vomiting
Metabolism can lead to nephrotoxicity (Compound A)
Term
Desflurane
Definition
Volatile, inhaled anesthetic
Rapid induction (no use) and emergence
Hypotension via vasodilation
MAC 6.0%
Depressed ventilation
Causes nausea and vomiting
Term
Thiopental
Definition
Intravenous anesthetic
No longer available for use
Causes hypotension, tachycardia, apnea
Causes nausea and vomiting
Causes a drop in intracranial pressure
Term
Propofol
Definition
Intravenous anesthetic
Rapid offset despite prolonged infusions via liver and extra-hepatic metabolism
Causes hypotension and apnea, but no change in heart rate
Prevents nausea and vomiting
The ideal ambulatory anesthetic
Term
Etomidate
Definition
Intravenous anesthetic
Blockade of norepinephrine uptake
Causes apnea, but no change in blood pressure or heart rate
Causes nausea and vomiting
Causes adrenocortical suppresion
Good for hemodynamic compromise
Term
Ketamine
Definition
Intravenous anesthetic
Used as a recreational street drug
Provides analgesia and does not usually cause apnea
Causes high intracranial pressure, dysphoria
Good for hemodynamic compromise
Term
Dantrolene
Definition
Inhibits Ca release during malignant hyperthermia
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