Term
| Unionized vs ionized forms (local) |
|
Definition
Unionized- pref enter the epineurium and the cell membrane
Ionized- Bind the channel |
|
|
Term
|
Definition
| Bind and stabilize inactive state of sodium channels |
|
|
Term
| Order of fxnal block (locals) |
|
Definition
| 1. pain 2. cold 3. warmth 4. touch 5. deep pressure 6. Motor fxn |
|
|
Term
|
Definition
Plasma esterase Metabolism can cause allergic rxns
PABA interferes with sulfonamides |
|
|
Term
|
Definition
| CytP450 (bad with liver problems) |
|
|
Term
|
Definition
Amide type
-Moderated duration
-Good for IV regional anesthesia |
|
|
Term
|
Definition
Ester type (PABA)
-slow onset, short duration (low protein binding) |
|
|
Term
|
Definition
Amide type
-Toxic in neonates |
|
|
Term
|
Definition
Amide Type
-Cardiotoxic
-Long acting (long surgeries)
-Good for OB because doesn't block mucle |
|
|
Term
|
Definition
Amide type
-Long acting
-Blocks muscle |
|
|
Term
|
Definition
Ester type
-Slower metabolism/more systemic toxicity |
|
|
Term
|
Definition
Ester type
-Decrease operative bleeding (blocks reuptake of NE) |
|
|
Term
|
Definition
Ester type
Popular topical, low solubility
-Methemoglobinemia |
|
|
Term
|
Definition
|
|
