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Details

local anesthesia chapters 1 & 2
pharm...
45
Dentistry
Undergraduate 3
08/27/2014

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Cards

Term
the history of pain control in the 1800s includes?
Definition

alcohol

 

opium

 

ether

 

acetylated salicylic acid (aspirin)

 

nitrous oxide

Term
history in the 1900s for pain control includes?
Definition
Halothane
Term
in the 1860's what was the local anesthetic of choice?
Definition
cocaine in 1860's
Term
what was the ester used in 1905  that is no longer used in U.S.?
Definition
procaine/novacaine
Term
what are the amides that were used since 1940's that are more potent and less allergenic?
Definition
lidocaine
Term

another name for bupivicaine

(hint: it is super long lasting and contains epi)

Definition
marcaine
Term
what are articaine and septicaine used for?
Definition
infiltration only
Term
if someone is fatigued, stressed, or in a difficult emotional state will they have a higher or lower pain threshold?
Definition
lower pain threshold, more suceptible, vulnerable
Term

T/ F

 

the elderly have a high pain threshold.

Definition
True, elderly can tolerate more pain.
Term
what are good tactics for stress reduction for a patient?
Definition

morning appts

 

short appts

 

middle of the week

Term
how to identify stress in patient
Definition

-cancelled appts

 

-cold, sweaty palms

 

-stiff posture

 

-quick answers

 

-perspiration

 

-white knuckles

Term
what are the components of the Central Nervous System?
Definition

Brain

 

spinal cord

Term
What are the components of the Peripheral nervous system?
Definition

nerve tissues outside the brain

 

31 pairs of spinal nerves

 

12 cranial nerves

Term
what does the sympathetic nervous system do?
Definition
it stimulates fight or flight/ adrenaline
Term
what does the parasympathetic nervous system do?
Definition

slows heart/ during rest and relaxation

 

rest and digest

Term
what are 2 ways to categorize the nervous system?
Definition

1.direction of information

 

2.function

Term
what promotes better saliva flow
Definition
pilocarpene
Term
what are the different directions of information?
Definition

AFFERENT- incoming info, from source to brain.

 

EFFERENT-outgoing from brain to source.

Term
when discussing the function of nervous tissue what does the somatic do?
Definition

somatic is part of efferent (outgoing message/signal from brain)

 

controls the voluntary and reflex activity

 

part of skeletal muscles and gland cells

Term
the function of the Atonomic nervous system
Definition

carries info to ANS or visceral effectors

 

controls involuntary smooth muscle, cardiac muscle, gland tissue.

Term
neurons
Definition
functional unit enabling communication between CNS and body
Term
what is the cell that is responsible for making myelin
Definition
schwan cells
Term
outer barrier of myelin that is smaller but gets local faster (does not last long anesthatized)
Definition
mantel
Term
the nerves are surrounded by a layer of connective tissue called/
Definition
endoneurium
Term
do thicker or thinner neurons send message faster?
Definition
thicker neurons send messages faster
Term
some neurons are myelinated.  they are covered with a protective coating, what is this made up of?
Definition
myelinated neurons are coated with a thick lipid layer
Term
nodes of ranvier
Definition
gaps in the myelin sheath, evenly spaced interruptions, enables saltatory  conduction to send messages
Term
which neurons move faster, myelinated, or unmyelinated?
Definition
mylinated neurons move faster.
Term
if neurons are myelinated can they be repaired?
Definition
yes myelinated can be repaired, which means unmyelinated cannot repair
Term
what kind of energy is used for neurons(for saltatory conduction)
Definition

action potential is used!!

 

jumps from on node of ranvier to the next to depolarize the threshold.

 

energy is saved.

Term
type A fibers of the peripheral nerve system.
Definition

-largest

-abundant in oral cavity

-require more anesthetic

-responsible for conducting pressure and motor sensory

-contains 4 groups

Term
what are the 4 types of type A fibers of PNS?
Definition

alpha-large, fat

 

beta- medium, light myelination, proprioception(awareness of postition)

 

gamma-touch and pressure

 

delta-pain and tempurature

Term
PNS type B fibers
Definition

medium in diameter

 

light myelination

Term
PNS type C fibers
Definition

-small

 

-most numerous

 

-unmyelinated

 

easy to anesthetize

Term
what allows sodium channels to open?
Definition
depolarization
Term
what direction does sodium travel in depolarization?
Definition
sodium goes from outside to inside in depolarization
Term
what direction does potassium travel in depolarization through sodium channels?
Definition
from inside to outside for potassium
Term
membrane potential
Definition
difference between the + & the - on inside and outside.
Term
when in normal or resting state pre depolarization where is potassium and where is sodium?
Definition

sodium is in outside (extracellular fluid) while resting

 

potassium is inside (intracellular fluid) while resting

Term
what does it take to make a change in polarization
Definition
-70 mV (range of -40--95mV)
Term
what can stimulate neurons
Definition

chemical, thermal, mechanical, electrical 

 

these allow for polarization (rest) to depolarization (active)

 

sodium goes in (from out)

 

potassium goes out (from in)

 

sodium gets in due to calcium channels open due to stimulation.

Term
all or none principle
Definition
after stimulus goes above threshold potential, more ion channels are stimulated to open and more sodium ions get in which cause complete depolarization.
Term
how do local anesthetic actions work
Definition
act by inhibiting the sodium influx(interferes with sodium channels).
Term
what is the order of local anestheisia effectiveness?
Definition

-small myelinated axons

 

-non myelinated axons

 

-large myelinated axons

Term
do the IA and PSA have small or large nerve trunks?
Definition
IA and PSA have large nerve trunks
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