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Lipoprotein Disorders
Lipoprotein Disorders
6
Medical
Graduate
01/24/2011

Additional Medical Flashcards

 


 

Cards

Term

Type I

 

Familial Hyperchylomicronemia

Definition

-massive fasting hyperchylomicronemia following normal dietary intake

-->high levels if TGs

-Deficiency in LPL or Apo CII(rare)--> an LPL activator

-symptoms: eruptive xanthomas, pancreatitis

-not assoc. with increased CHD

-treatment: low fat diet, no effective drug therapy

Term

Type IIA

 

Familial Hypercholesterolemia

Definition

  • elevated LDL bc degradation blocked bc increased serum cholesterol
  • normal VLDL
  • genetic defect in synthesis/processing/function in LDL receptor
  • ischemic heart disease greatly increased
  • treatment: low cholesterol, saturated fat diet

 

Term

Type IIB

 

Familial Combined Hyperlidpidemia

Definition

  • similar to IIA except VLDL also increased bc elevated serum TG & cholesterol
  • caused by hepatic overproduction of VLDL (common)
  • treatment: low cholesterol,saturated fat & alcohol

Term

Type III

 

Familial Dysbetalipoproteinemia

Definition

  • serum IDL increase bc increased TG & cholesterol
  • caused by overproduction/underutilization of IDL bc mutant ApoE that faciliate chylomicron & VLDL remnant uptake by liver
  • symptoms: xanthomas, accelerated CHD, peripheral vascular disease develop by middle age
  • treatment: weight loss, dietary restriction of cholesterol & alcohol, drug therapy with niacin & clofibrate/statin

Term

Type IV

 

Familial Hypertriglyceridemia

Definition

  • VLDL levels increased
  • caused by overproduction and/or decreased removal of VLDL TGs in serum
  • patients frequently obese, diabetic, hyperuricemic, undergoing estrogen therapy, pregnant, alcoholic
  • common disease w/ few clinical manifestations other than accelerated CHD
  • treatment: weight loss very important, dietary restriction of carbs, fat, and low alcohol

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