Term
| Bile Acid Sequestrant Prototype |
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Definition
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Term
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Definition
| Second line agent. Resins bind bile acids in the gut, then the liver converts more cholesterol to bile. Decreases LDL by 15-30%. |
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Term
| How long before you see results of Questran |
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Definition
|
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Term
| What lipid lowering agent would you expect to see used for young populations and for moderately elevated cholesterol levels? |
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Definition
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Term
| What do you use with Questran for severe hypercholesterolemia? |
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Definition
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Term
|
Definition
Constipation, bloating, N, flatulence.
Bone: Osteoporosis (long term) |
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Term
| When is Questran not recommended |
|
Definition
| In patients with triglyceride levels greater than 200 mg/dl because it may increase them |
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Term
| What is important for the nurse to monitor with Questran |
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Definition
| GI distress, especially bowel elimination. Monitor fluids (needs high fluid consumption), monitor pt dig levels |
|
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Term
| when a pt is on Questran, how often should their cholesterol levels be checked |
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Definition
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Term
| What does Questran decrease the absorption of |
|
Definition
| Vitamins ADEK, thaizides, beta blockers, Digoxin, coumadin |
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Term
|
Definition
| A powder that is mixed with liquid or food |
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Term
| Fibric Acid Derivative prototype |
|
Definition
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Term
|
Definition
- Increases lipoprotein lipase (enzyme)activity so increases catabolism of VLDL & LDL
- Decreases. TG’s up to 50% |
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Term
|
Definition
1.Used to tx elevated LDL levels.
2.severe hyperlipedemia in pts with risk of CHD or pancreatitis,
3.Tx familial hyperlipidemia |
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|
Term
| What is lopid w/ niacin or statin used for |
|
Definition
| Prevention of heart dx, elevated LDL, high TG and low HDL |
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Term
|
Definition
1.Gallstones (Cholelithiasis)
2. N/V
3. Skin rash
4. Hepatotoxicty |
|
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Term
| Is Lopid long term or short term use? |
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Definition
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Term
| Nursing implications for lopid |
|
Definition
| Monitor INR, assess for Hx for gallbladder and liver dx, check LFTs q 6-8 weeks initially |
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|
Term
| what does lopid do to coumadin |
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Definition
|
|
Term
| What does lopid do to phenytoin? |
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Definition
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Term
| Statins/HGM CoA prototype |
|
Definition
|
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Term
|
Definition
First line agent! Inhibit synthesis of
cholesterol by the liver
-inhibits HMG-CoA enzyme
- Decr. LDL by 30-40%
- Incr.HDL by 15%
- DecreasesTG’s 10-40% |
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|
Term
| What would you expect a patient to be given to prevent 1st or 2nd MI in patients with CAD, DM, or hyperlipidemia? |
|
Definition
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|
Term
| What Lipid lowering agent would you expect to see in older patients? |
|
Definition
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|
Term
| What is lovastatin indicated for? |
|
Definition
| Tx of hypercholesterolemia caused by elevated LDL |
|
|
Term
|
Definition
1.Dyspepsia (indigestion), flatulence, constipation, ab pain and cramps
2. Hepatoxicity |
|
|
Term
| What lipid lowering agent can cause Rhabdomyolysis? |
|
Definition
|
|
Term
| What Statin causes an alteration of prothrombin time? |
|
Definition
|
|
Term
| What does lovastatin do to pts on coumadin |
|
Definition
|
|
Term
| Who is lovastatin contraindicated in? |
|
Definition
| Pregnant women, children under 18 |
|
|
Term
| when should you check LFTs for lovastatin |
|
Definition
|
|
Term
| What should a patient report if they are on lovastatin? |
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
| What type of vitamin is Niacin |
|
Definition
|
|
Term
|
Definition
| -Decreases LDLs 10-20% (inexpensive and effective) |
|
|
Term
| How often do you take Niacin |
|
Definition
|
|
Term
| What is Niacin's therapeutic dose |
|
Definition
| 100-200x the daily requirement |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Flushing, itching, gout, abnormal liver function |
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|
Term
| What can Niacin aggravate? |
|
Definition
1. Peptic Ulcer
2. Diabetes (hyperglycemia) |
|
|
Term
| Why should you take aspirin 30 min before Niacin? |
|
Definition
|
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Term
| Niacin nursing implications/teaching |
|
Definition
-Take aspirin 30 min before (for flushing)
-Start doses slow then increase
-DO NOT chew tablets
-Monitor blood glucose
-Take WITH meals |
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