Term
Drug Substance: Physiochemical Properties
- Particle Size |
|
Definition
Physiologic Factors & Pt Characteristics
- Gastric Emptying time |
|
|
Term
Drug Substance: Physiochem Properties
- Crystalline or amorphous form |
|
Definition
Physiologic Factors & Pt Characteristics
- Intestinal Transit Time |
|
|
Term
DS: Physiochem Props
- Lipid/ Water solubility |
|
Definition
PF & PC
Gastrointestinal abnormality/pathologic condtion |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Dosage form chars:
Disintegration rate |
|
Definition
| drug metabolism (gut and first pass) |
|
|
Term
|
Definition
| drug metabolism (gut and first pass) |
|
|
Term
|
Definition
| drug metabolism (gut and first pass) |
|
|
Term
| Pharmaceutical Excipients |
|
Definition
| An excipient is a natural or synthetic substance formulated alongside the active ingredient of a medication, :1 included for the purpose of bulking-up formulations |
|
|
Term
| Types of pharmaceutical Excipients |
|
Definition
| Filler, binders, coatings, lubricants, surface active agents, disintegrating agents |
|
|
Term
| Pulmonary Route of Administration |
|
Definition
Fast absorption, bypassing the liver.
Drugs reach left atrium, ventricle and general circulation.
Used for: bronchial diseases, antibiotics, mucolytic, beta-adrenergic mimetic, muscarinic receptor agonists. |
|
|
Term
|
Definition
| Advantages: avoid intestinal and hepatic first-pass metabolism, fast absorption and to treat pulmonary diseases. Could be used for drugs like heparin and insulin. |
|
|
Term
| Disadvantages for Pulmonary |
|
Definition
| Large variability in dose delivery to alveoli, large variability in patient techniques for device utilization, narrow particle size distribution required for optimal therapeutic effect, anatomical barriers to reaching alveoli. |
|
|
Term
|
Definition
Intradermal: 10-15 degree angle
SubQ: 45 degree angle
Intramuscular: 90 degree angle |
|
|
