Term
| Define the concept of a Ligand |
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Definition
| Biologically active signaling molecules of the cell, they can be cytokines, lymphokines or interleukins |
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Term
| Explain the different roles of ligands in immune reactions (4 roles) |
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Definition
| (1) signaling molecules (cytokines and interleukins) (2)opsonins (coat bacteria for phagocytosis) (3) trafficking/homing molecules (chemokines) (4) cell/cell interactions (adhesion factors and co-receptors) |
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Term
| Describe the structure and mechanisms of action of the receptors |
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Definition
| Receptors are made of different chains, they determine antibody reactions, and signal affinity |
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Term
| Compare and contrast the MHC class I and the MHC class II molecule expression on different types of cells |
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Definition
| MHC class I are on all nucleated cells, MHC class II are on most hematopoietic cells, thymic epitheial cells and microglial cells in the brain |
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Term
| What is the role of MHC in humoral immunity? |
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Definition
| • MHC II interacts with CD4+ receptors and presents to helper T cells in humoral immunity to ensure the proliferation of B cells into plasma cells and the production of antibodies |
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Term
| What is the role of MHC in cellular immunity? |
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Definition
| • MHC I interacts with CD8+ receptors and presents to cytotoxic T cells in cellular immunity to ensure destruction of the cell by the cytotoxic T cells |
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Term
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Definition
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Term
| Peripheral lymphoid organs |
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Definition
| Lymph nodes, spleen, tonsils and the MALT |
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