Term
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Definition
-membrane bound Ig
-free Ig
-bind to pathogen or its products
-coat/opsonize pathogen/bacteria
-binding neutralizes pathogen
-recruit other cells and/or molecules to destroy pathogen |
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Term
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Definition
-B cell receptors
-antigen receptors (BCR)
-do not have effector functions because constant region is bound in membrane |
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Term
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Definition
-activated B cells called plasma cells secrete Ig
-Ig circulates throughout body |
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Term
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Definition
-a single B cell clone circulating throughout body
-encounters antigen
-becomes activated
-becomes plasma cell
-divides and creates many clones
-clones secret Ig specific to antigen |
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Term
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Definition
-four polypeptide chains
-2 50kDa heavy chains
-2 25kDa light chains
-connected by disulfide bonds
-variable regions and constant regions |
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Term
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Definition
| the strength of the antigen antibody interaction |
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Term
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Definition
| combined strength of multiple binding sites |
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Term
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Definition
-two types: Lambda and Kappa
-only one or the other type, never mixed
-no functional difference
-two domains |
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Term
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Definition
-stucture defines class
-four domains |
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Term
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Definition
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Term
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Definition
-antigen binding at tips
-Fab fragments |
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Term
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Definition
-constant
-function: effector, activates other cells and molecules |
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Term
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Definition
-can bind antigen
-still able to interact with effector molecules
-light and heavy chain fragments |
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Term
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Definition
-constant region
-unable to interact with effector molecules |
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Term
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Definition
-adaptive immunity
-T cells main role
-antigen presented to T cells
-difficult to measure |
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Term
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Definition
-immunity due to proteins such as complement or Ig circulating in blood and bathing tissues
-Ig production
-easily measured: draw blood sample and titer for antibodies |
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